What is Carbidopa-Levodopa 25-100?

Category: Prescription Drugs

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Generic name: Carbidopa-Levodopa

Levodopa 100 mg, a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease is combined with carbidopa 25 mg. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's Disease 275 296
Stiffness/Spasticity 11 10
Tremor in hands 11 15
MSA (Multiple System Atrophy) 9 9
Dystonia 6 10
Increase effect of another treatment 6 9

Show all 34 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 8
Moderate 55
Mild 111
None 130

Commonly reported side effects and conditions associated with Carbidopa-Levodopa 25-100

Side effect Patients
Jerky movements (dyskinesia) 27
Drowsiness 13
Nausea 12
Dizziness 5
Dry mouth 4
Lightheadedness 4

Show all 83 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa 25-100

Dosage Patients
3 x 25 mg-100 mg daily 7
4 x 25 mg-100 mg daily 6
25-100 mg three times daily 5
25 mg-100 mg three times daily 4
6 x 25 mg-100 mg daily 4
25 mg-100 mg daily 3
25 mg-100 mg four times daily 3
8 x 25 mg-100 mg daily 3
25-100 mg five times daily 2
2 x 25-100 mg four times daily 2

See all 32 dosages

Why patients stopped taking Carbidopa-Levodopa 25-100

Multiple reasons could be selected

Reason Patients
Doctor's advice 15
Other 11
Personal research 6
Side effects too severe 6
Did not seem to work 5
Course of treatment ended 3
Change in health plan coverage 1
See all 38 patients who’ve stopped taking Carbidopa-Levodopa 25-100

Duration

Currently taking Carbidopa-Levodopa 25-100

Duration Patients
1 - 6 months 4
6 months - 1 year 3
1 - 2 years 3
2 - 5 years 20
5 - 10 years 27
10 years or more 9

Stopped taking Carbidopa-Levodopa 25-100

Duration Patients
Less than 1 month 4
1 - 6 months 6
6 months - 1 year 5
1 - 2 years 4
2 - 5 years 11
5 - 10 years 7
10 years or more 1
Adherence
Adherence Evaluations
Always 223
Usually 61
Sometimes 12
Never taken as prescribed 8
Burden
Burden Evaluations
Very hard to take 9
Somewhat hard to take 54
A little hard to take 74
Not at all hard to take 167
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 1
$50-99 5
$25-49 33
< $25 204
Not specified 61

What people switch to and from

Patients started taking Carbidopa-Levodopa 25-100 after stopping:

Treatment Patients
Carbidopa-Levodopa CR (Sinemet CR) 4
Carbidopa-Entacapone-Levodopa (Stalevo) 2
Carbidopa-Levodopa (Sinemet) 2
Carbidopa Levodopa ER (Rytary XR) 2
Entacapone (Comtan) 2

Show all 7 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa 25-100 and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 7
Carbidopa-Entacapone-Levodopa (Stalevo) 3
Carbidopa-Levodopa (Sinemet) 1
Pramipexole (Mirapex) 1
Last updated:

29 patient evaluations for Carbidopa-Levodopa 25-100

142 members have decided to share their profiles only with other members of PatientsLikeMe.

margie99
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margie99
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See margie99's full Carbidopa-Levodopa 25-100 history

Jan 17, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Moderate (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit.
Cost: < $25 monthly

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: crackers help
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Moderate (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I continue to be nausea, but crackers help.
Cost: < $25 monthly

  • 0 helpful marks
reikihh
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reikihh
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See reikihh's full Carbidopa-Levodopa 25-100 history

Jan 12, 2017 (Started Jun 30, 2004)

  • Effectiveness
    Major (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I am so afraid of increasing my dose of carbidopa/levadopa that I still have not even tried it. I might be able to move better if I increased it but I fear the nausea, the dyskinesia, the near syncope. However, I have such back pain that it interferes with everythingI want to do. I can only walk for a short time before I am looking for a place to sit. That eliminates any tours, any walks in the woods. I used to enjoy walking. And I have gained a lot of weight from being sedentary.
Cost: < $25 monthly

Apr 24, 2016 (Started Jun 30, 2004)

  • Effectiveness
    Can’t tell (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: The carbidopa/levodopa works the best for me to lessen the symptoms of PD. Other Rx drugs I tried didn't work as well or they worked well for symptoms but caused syncope or near syncope and left me feeling drained. It took many months to find the right med & the right dose. I do realize that carb/levo may cause tardive dyskinesia before it's over. But right now it is the best I can do & I want to enjoy it while I can. I can do quite a bit still . I owe that to the carb/levo.
Cost: < $25 monthly

Nov 26, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Very hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: My niece showed me how to set my iPhone clock to have a timer go off every day at 1pm to remind me to take my mid day dose of carb/levo & pramipexole. It works!!! It has worked. I have not missed a day since using the timer. I now am aware of "wearing off" of the meds. I never noticed it until a few months ago. At my last appt with Neurologist he increased my carb/levo to 1 1/2 TID. He said to increase gradually. I haven't increased just yet because I want to be firmly on the previous dose first which I am with this timer helping me. Soon I will try the new increase.
Cost: < $25 monthly

Jun 5, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Can’t tell (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: Now I am taking a new dose-1 TID-gradually titrating up from 1/2 TID. I still miss my noon dose although not as often. It is difficult remembering. I do notice the increase in dose is helping me stand up straighter longer & within about an hour of taking my dose. It is a pain in the neck to take 3 x a day but it improves my symptoms.
Cost: < $25 monthly

Feb 11, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Major (for RLS (Restless Legs Syndrome))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I no longer am seeing any improvement. Maybe I have just gotten used to it & no longer notice it. Maybe it is time to increase again.
Cost: < $25 monthly

Nov 10, 2014 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: This formula (immediate release) was given so I can see if I can get more carb/levo into me for better symptom control, but the problem with this formula is that I have a hard time remembering the noon dose. I am having an easier time remembering it now that I am retired, but I still forget sometimes. So far I MAY have experienced improvement in symptoms: I occasionally get relief from my back pain. I think the pain is caused by the postural changes with PD & anything I do to correct posture relieves the pain. This 1/2 pill taken 3x a day gives me more levo than I was getting with the CR 50/200 1/2 daily. Just that small amt more seems to have helped me stand up better which relieves the pain.
Cost: < $25 monthly

  • 0 helpful marks
egaspar
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egaspar
Sex: F
Data Quality: 1 star
Off
Mouth/throat: none
Arms: none
Chest: mild
Legs: none
I am: n
I have:
Parkinson's

See egaspar's full Carbidopa-Levodopa 25-100 history

Jan 3, 2017 (Started Mar 01, 2012)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Moderate (Heartburn, Nausea during and after eating)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 6 x 25-100 mg Daily
Advice & Tips: when I first started this treatment the doctor prescribed Levadopa 25mg to balance out the nausea . It really seem to work well . I've since been taken off the additional Levadopa since my insurance will not cover it . If your insurance will cover it then I would advise asking about the Levadopa 25mg to go with the carbadopa/levadopa 100/25mg if you have nausea .
Cost: $50-99 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 29 patient evaluations for Carbidopa-Levodopa 25-100