What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

false

Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's Disease 2,431 1,415
Stiffness/Spasticity 111 71
MSA (Multiple System Atrophy) 76 51
RLS (Restless Legs Syndrome) 66 40
Tremor(s) 58 56
Slowness 48 32

Show all 98 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 71
Moderate 309
Mild 480
None 662

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Dyskinesia 124
Nausea 114
Drowsiness 43
Jerky movements (dyskinesia) 26
Stomach upset 24
Headaches 21

Show all 300 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 44
25 mg-100 mg three times daily 40
3 x 25 mg-100 mg daily 34
25-100 mg four times daily 20
4 x 25 mg-100 mg daily 20
25 mg-100 mg four times daily 19
6 x 25 mg-100 mg daily 17
2 x 25-100 mg three times daily 15
2 x 25-100 mg four times daily 15
25 mg-100 mg daily 14

See all 165 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 123
Did not seem to work 94
Side effects too severe 77
Other 70
Personal research 27
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 336 patients who’ve stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 2
1 - 6 months 30
6 months - 1 year 34
1 - 2 years 83
2 - 5 years 188
5 - 10 years 194
10 years or more 63

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 36
1 - 6 months 81
6 months - 1 year 55
1 - 2 years 58
2 - 5 years 81
5 - 10 years 37
10 years or more 5
Adherence
Adherence Evaluations
Always 1109
Usually 335
Sometimes 38
Never taken as prescribed 40
Burden
Burden Evaluations
Very hard to take 53
Somewhat hard to take 256
A little hard to take 382
Not at all hard to take 831
Cost per month
Cost per month Evaluations
$200+ 11
$100-199 19
$50-99 59
$25-49 137
< $25 841
Not specified 455

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 32
Pramipexole (Mirapex) 22
Carbidopa-Entacapone-Levodopa (Stalevo) 15
Rasagiline (Azilect) 15
Amantadine (Symmetrel) 12

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 39
Carbidopa-Entacapone-Levodopa (Stalevo) 10
Carbidopa-Levodopa CR (Sinemet CR) 6
Ropinirole (Requip) 6
Carbidopa-Levodopa (Sinemet) 5

Show all 16 treatments patients report switching to

Last updated:

126 patient evaluations for Carbidopa-Levodopa

962 members have decided to share their profiles only with other members of PatientsLikeMe.

J.Marley
20395 thumb
J.Marley
Sex: M
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See J.Marley's full Carbidopa-Levodopa history

Nov 28, 2016 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Dyskinesia, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Dec 15, 2015 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Dyskinesia, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: This summer I had to lower my total intake of carbidopa / levodopa as I began to experience dyskinesia in the evenings.  If I keep my daily levodopa dose at or below 1200 mgs, I seldom experience any dyskinesia.
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Dec 17, 2012 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Advice & Tips: I take the regular Sinemet pill as a 'back-up' to my extended release Sinemet when I go to the gym, paint or do something during which time I hope to lesson my tremors - it does seem to help.
Cost: < $25 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jul 6, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jun 30, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jun 29, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

  • 0 helpful marks
Napiejoe
30221 thumb
Napiejoe
Sex: M
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: none
Legs: mild
I am: g
I have:
Parkinson's

See Napiejoe's full Carbidopa-Levodopa history

Nov 10, 2016 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Dyskinesia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25-250 mg Five times daily
Cost: $25-49 monthly

May 26, 2015 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Moderate (Dyskinesia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 x 25 mg-250 mg Daily
Cost: < $25 monthly

May 19, 2013 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Dyskinesia)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 4 x 25 mg-100 mg Daily
Advice & Tips: I use a talking alarm watch to help me take my medication on time.
Cost: < $25 monthly

May 24, 2009 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 x 25 mg-100 mg Daily
Advice & Tips: Take your pills on time
Cost: $25-49 monthly

  • 0 helpful marks
margie99
70573 thumb
margie99
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: moderate
I am: g
I have:
Parkinson's

See margie99's full Carbidopa-Levodopa history

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: crackers help
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Moderate (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I continue to be nausea, but crackers help.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 126 patient evaluations for Carbidopa-Levodopa