What is Intravenous Immunoglobulin (IVIG)?

Category: Prescription Drugs

Most popular types: Gammaglobulin (IVIg) Gammagard Gamunex Show all

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Intravenous Immune Globulin (IVIG) is a human blood product consisting of antibodies which is used to treat immunodeficiency disorders, B-cell chronic lymphocytic leukemia, inflammatory demyelinating disorders. It may also be used to treat Guillain-Barré, Multiple Sclerosis, and myasthenia gravis.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple Sclerosis 73 52
CIDP (Chronic inflammatory demyelinating polyneuropathy) 50 29
Hypogammaglobulinemia 46 41
Myasthenia Gravis 46 24
CVID (Common Variable Immunodeficiency Disorder) 40 28
Multifocal Motor Neuropathy 20 16

Show all 104 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 30
Moderate 56
Mild 111
None 84

Commonly reported side effects and conditions associated with Intravenous Immunoglobulin (IVIG)

Side effect Patients
Headaches 71
Fatigue 22
Nausea 20
Migraine headaches 17
Flu like symptoms 11
Fever/chills 7

Show all 141 reported side effects

Dosages

Based on patients currently taking Intravenous Immunoglobulin (IVIG)

Dosage Patients
10 g every other week 3
30 g monthly 3
30 mg monthly 3
35 g monthly 3
40 g monthly 3
100 mg monthly 3
10 g monthly 2
50 g every 3 weeks 2
50 mg every 3 weeks 2
300 mg weekly 2

See all 51 dosages

Why patients stopped taking Intravenous Immunoglobulin (IVIG)

Multiple reasons could be selected

Reason Patients
Did not seem to work 69
Course of treatment ended 66
Doctor's advice 51
Side effects too severe 32
Other 30
Expense 14
Change in health plan coverage 13
Personal research 4
See all 202 patients who’ve stopped taking Intravenous Immunoglobulin (IVIG)

Duration

Currently taking Intravenous Immunoglobulin (IVIG)

Duration Patients
1 - 6 months 8
6 months - 1 year 7
1 - 2 years 12
2 - 5 years 24
5 - 10 years 11
10 years or more 8

Stopped taking Intravenous Immunoglobulin (IVIG)

Duration Patients
Less than 1 month 70
1 - 6 months 50
6 months - 1 year 25
1 - 2 years 22
2 - 5 years 26
5 - 10 years 10
10 years or more 4
Adherence
Adherence Evaluations
Always 250
Usually 9
Sometimes 3
Never taken as prescribed 19
Burden
Burden Evaluations
Very hard to take 31
Somewhat hard to take 95
A little hard to take 78
Not at all hard to take 77
Cost per month
Cost per month Evaluations
$200+ 55
$100-199 6
$50-99 2
$25-49 8
< $25 77
Not specified 133

What people switch to and from

Patients started taking Intravenous Immunoglobulin (IVIG) after stopping:

Treatment Patients
Methylprednisolone (Solu-Medrol Infusion) 3
Mycophenolate mofetil (CellCept) 3
Subcutaneous immune globulin (Hizentra) 3
Azathioprine (Imuran) 2
Cyclophosphamide (Cytoxan) 2

Show all 16 treatments patients report switching from

Patients stopped taking Intravenous Immunoglobulin (IVIG) and switched to:

Treatment Patients
Subcutaneous immune globulin (Hizentra) 9
Rituximab (Rituxan) 2
Cyclophosphamide (Cytoxan) 1
Intravenous Immunoglobulin (IVIG) (Gammaglobulin (IVIg)) 1
Methotrexate (Apo-Methotrexate) 1

Show all 11 treatments patients report switching to

Last updated:

17 patient evaluations for Intravenous Immunoglobulin (IVIG)

210 members have decided to share their profiles only with other members of PatientsLikeMe.

firefly84
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firefly84
Data Quality: 3 stars
  • Gender: F
  • Age: 32
Condition: Autonomic Neuropathy 26 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Moderate
I am: b
I have:
Autonomic Neuropathy

See firefly84's full Intravenous Immunoglobulin (IVIG) history

Jan 16, 2017 (Started Nov 12, 2015)

  • Effectiveness
    Major (for Hypogammaglobulinemia)
  • Side effects
    Mild (Weight gain, Abdominal pain, Migraine, Fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Monthly
Advice & Tips: My 12/6/16 infusion had a lot fewer side effects the next day and also the night of. My new immunologist had D5NS infuse at 20 mL/hr in addition to the Gammagard Liquid at my maximum tolerable rate of 40 mL/hr. Having the D5NS really seemed to make a big difference in the decreased side effects. Basically I was just really fatigued for a couple days.

Aug 27, 2016 (Started Nov 12, 2015)

  • Effectiveness
    Major (for Hypogammaglobulinemia)
  • Side effects
    Mild (Weight gain, Abdominal pain, Migraine, Fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 g Monthly
Advice & Tips: With the Gammagard, I have noticed that my weight jumps about 9 pounds after each infusion. The weight change takes place overnight and after about 7 days, my weight is back to baseline. My insurance requires a new prior authorization every 3 months, which makes it something else that I have to keep tabs on. 

Nov 16, 2015 (Started Nov 12, 2015)

  • Effectiveness
    Can’t tell (for Hypogammaglobulinemia)
  • Side effects
    Moderate (Weight gain, Abdominal pain, Migraine, Fatigue)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 25 g Monthly

  • 1 helpful mark
firefly84
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firefly84
Data Quality: 3 stars
  • Gender: F
  • Age: 32
Condition: Autonomic Neuropathy 26 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Moderate
I am: b
I have:
Autonomic Neuropathy

See firefly84's full Intravenous Immunoglobulin (IVIG) history

Nov 1, 2015 (Started May 15, 2015)

  • Effectiveness
    Major (for Hypogammaglobulinemia)
  • Side effects
    Moderate (Abdominal pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25000 mg Monthly

  • 0 helpful marks
Navyarmymom8
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Navyarmymom8
Data Quality: 1 star
  • Gender: F
  • Age: 53
Condition: Myasthenia Gravis 5 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Moderate
I am: b
I have:
Myasthenia Gravis

See Navyarmymom8's full Intravenous Immunoglobulin (IVIG) history

Jul 20, 2015 (Started Jun 22, 2015)

  • Effectiveness
    None (for Myasthenia Gravis)
  • Side effects
    Severe (Allergic reaction)
  • Adherence
    Never taken as prescribed
  • Burden
    Very hard to take
Advice & Tips: After 15 min at a drip of 36ml an hr....the ivig was turned off due to my body rejecting treatment with allergic reactions or flushing, numbness in mouth and starting of angioedema.

  • 0 helpful marks
Last updated:
Showing 3 of 17 patient evaluations for Intravenous Immunoglobulin (IVIG)