What is Duloxetine?

Category: Prescription Drugs

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,348 3,213
Depressed mood 2,077 1,239
Major depressive disorder 1,923 1,172
Generalized anxiety disorder 797 573
Myalgic encephalomyelitis/chronic fatigue syndrome 693 385
Pain 536 320

Show all 325 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 933
Moderate 1,020
Mild 1,152
None 1,772

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 336
Nausea 287
Decreased sex drive (libido) 185
Dry mouth 169
Dizziness 160
Sweating increased 100

Show all 603 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 386
30 mg daily 144
120 mg daily 135
90 mg daily 73
60 mg twice daily 66
20 mg daily 47
30 mg twice daily 21
40 mg daily 16
20 mg twice daily 13
120 mg twice daily 13

See all 38 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1754
Did not seem to work 1551
Doctor's advice 587
Expense 446
Other 435
Personal research 176
Change in health plan coverage 160
Course of treatment ended 69
See all 3491 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 10
1 - 6 months 19
6 months - 1 year 48
1 - 2 years 113
2 - 5 years 281
5 - 10 years 341
10 years or more 162

Stopped taking Duloxetine

Duration Patients
Less than 1 month 814
1 - 6 months 933
6 months - 1 year 551
1 - 2 years 497
2 - 5 years 520
5 - 10 years 156
10 years or more 37
Adherence
Adherence Evaluations
Always 4080
Usually 436
Sometimes 75
Never taken as prescribed 286
Burden
Burden Evaluations
Very hard to take 300
Somewhat hard to take 370
A little hard to take 578
Not at all hard to take 3629
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 191
$50-99 435
$25-49 691
< $25 1574
Not specified 1860

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 152
Fluoxetine (Prozac) 133
Venlafaxine (Effexor XR) 124
Sertraline (Zoloft) 112
Citalopram (Celexa) 99

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 78
Venlafaxine (Effexor XR) 71
Gabapentin (Neurontin) 57
Escitalopram (Lexapro) 38
Bupropion (Wellbutrin XL) 37

Show all 78 treatments patients report switching to

Last updated:

320 patient evaluations for Duloxetine

Mar 1, 2017 (Started Oct 30, 2013)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (insomnia, headaches, bitter taste, daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Jul 10, 2016 (Started Oct 30, 2013)

  • Effectiveness
    Can't tell (for fibromyalgia)
  • Effectiveness
    Can't tell (for depressed mood)
  • Side effects
    Moderate (insomnia, headaches, bitter taste, daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Cost: < $25 monthly

Jul 7, 2016 (Started Oct 30, 2013)

  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Can't tell (for depressed mood)
  • Side effects
    Mild (insomnia, headaches, bitter taste, daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Cost: < $25 monthly

Jul 3, 2016 (Started Oct 30, 2013)

  • Effectiveness
    Can't tell (for fibromyalgia)
  • Effectiveness
    Can't tell (for depressed mood)
  • Side effects
    Mild (daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Cost: < $25 monthly

Nov 2, 2013 (Started Oct 30, 2013)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Severe (daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: $50-99 monthly

Oct 30, 2013 (Started Oct 30, 2013)

  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Can't tell (for depressed mood)
  • Side effects
    Mild (daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 30 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks

Nov 20, 2016 (Started May 15, 2012)

  • Effectiveness
    None (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Severe (muscle and joint pain, muscle fatigue)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 180 mg Twice daily
Advice & Tips: This medication is habit forming and it’s withdrawal effects took nearly SEVEN MONTHS to wear off! Be careful when you are prescribed this medication..
Cost: < $25 monthly

  • 0 helpful marks

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can't tell (for postpartum depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can't tell (for postpartum depression)
  • Side effects
    Mild (seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can't tell (for postpartum depression)
  • Side effects
    Mild (seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can't tell (for postpartum depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
Last updated:
Showing 3 of 320 patient evaluations for Duloxetine