Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
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Treatments taken by people for major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin)
Type
Prescription Drug
How many have tried
16131
Tried for
major depressive disorder (162)
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
11846
Tried for
major depressive disorder (113)
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
19158
Tried for
major depressive disorder (101)
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
15520
Tried for
major depressive disorder (100)
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
23626
Tried for
major depressive disorder (87)
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
10570
Tried for
major depressive disorder (72)
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
18406
Tried for
major depressive disorder (63)
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
10836
Tried for
major depressive disorder (36)

Data from patients with major depressive disorder, who have ever reported treatments, ordered by their reporting frequency during the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin)
Perceived effectiveness
for major depressive disorder (77 evaluations)
Side effects
anxious mood dry mouth 47 more
Total evaluations
79
Tried for
major depressive disorder (162)
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (68 evaluations)
Side effects
dry mouth decreased sex drive (libido) 24 more
Total evaluations
69
Tried for
major depressive disorder (113)
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (46 evaluations)
Side effects
nausea weight gain 48 more
Total evaluations
48
Tried for
major depressive disorder (101)
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (61 evaluations)
Side effects
nausea dizziness 49 more
Total evaluations
64
Tried for
major depressive disorder (100)
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (24 evaluations)
Side effects
flashbacks emotional lability 8 more
Total evaluations
28
Tried for
major depressive disorder (87)
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (33 evaluations)
Side effects
brain fog decreased sex drive (libido) 35 more
Total evaluations
33
Tried for
major depressive disorder (72)
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (35 evaluations)
Side effects
headaches nausea 22 more
Total evaluations
37
Tried for
major depressive disorder (63)
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (30 evaluations)
Side effects
dizziness nausea 8 more
Total evaluations
30
Tried for
major depressive disorder (36)
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who have ever reported treatments, ordered by their reporting frequency during the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?

  • 173 new patients joined this month
  • 33245 say MDD is their primary condition

Age
Age Proportion # of patients
<20 130
20s 3279
30s 8477
40s 13419
50s 17239
60s 13306
70+ 4064
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8856
20-29 years 3723
30-39 years 2744
40-49 years 1752
50-59 years 611
60-69 years 115
70+ years 21

Distribution of sex

Sex
Sex Proportion # of patients
Male 12496
Female 47729

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23958
Not Diagnosed 2339

These charts show data from MDD patients who have completed their condition history
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