Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin)
Type
Prescription Drug
How many have tried
604
Tried for
major depressive disorder (561) depressed mood (78)
7 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
408
Tried for
major depressive disorder (377) depressed mood (71)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
408
Tried for
major depressive disorder (403) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
373
Tried for
major depressive disorder (330) depressed mood (103)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
365
Tried for
major depressive disorder (327) depressed mood (97)
4 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
305
Tried for
major depressive disorder (272) anxious mood (77)
2 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
298
Tried for
major depressive disorder (263) depressed mood (82)
3 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
168
Tried for
major depressive disorder (153) depressed mood (28)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
137
Tried for
depressed mood (109) major depressive disorder (33)
3 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
133
Tried for
anxious mood (129) major depressive disorder (3)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin)
Perceived effectiveness
for major depressive disorder (303 evaluations)
Side effects
dry mouth anxious mood 145 more
Total evaluations
370
Tried for
major depressive disorder (561) depressed mood (78)
7 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (217 evaluations)
Side effects
dry mouth weight gain 126 more
Total evaluations
272
Tried for
major depressive disorder (377) depressed mood (71)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (211 evaluations)
Side effects
anxious mood flashbacks 40 more
Total evaluations
253
Tried for
major depressive disorder (403) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (227 evaluations)
Side effects
decreased sex drive (libido) weight gain 116 more
Total evaluations
269
Tried for
major depressive disorder (330) depressed mood (103)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (227 evaluations)
Side effects
nausea dry mouth 115 more
Total evaluations
263
Tried for
major depressive disorder (327) depressed mood (97)
4 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (159 evaluations)
Side effects
decreased sex drive (libido) dry mouth 91 more
Total evaluations
192
Tried for
major depressive disorder (272) anxious mood (77)
2 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (167 evaluations)
Side effects
nausea decreased sex drive (libido) 82 more
Total evaluations
198
Tried for
major depressive disorder (263) depressed mood (82)
3 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (92 evaluations)
Side effects
nausea weight gain 46 more
Total evaluations
108
Tried for
major depressive disorder (153) depressed mood (28)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (72 evaluations)
Side effects
weight gain drowsiness 56 more
Total evaluations
111
Tried for
depressed mood (109) major depressive disorder (33)
3 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (64 evaluations)
Side effects
drowsiness sleepiness 16 more
Total evaluations
71
Tried for
anxious mood (129) major depressive disorder (3)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?

  • 37 new patients joined this month
  • 31657 say MDD is their primary condition

Age
Age Proportion # of patients
<20 297
20s 4212
30s 9379
40s 14151
50s 16834
60s 10707
70+ 2499
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8816
20-29 years 3725
30-39 years 2724
40-49 years 1748
50-59 years 610
60-69 years 114
70+ years 19

Distribution of sex

Sex
Sex Proportion # of patients
Male 12040
Female 46343

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23885
Not Diagnosed 2333

These charts show data from MDD patients who have completed their condition history
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