Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
846
Tried for
major depressive disorder (799) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
629
Tried for
major depressive disorder (587) depressed mood (109)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
563
Tried for
major depressive disorder (557) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
561
Tried for
major depressive disorder (476) depressed mood (183)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
553
Tried for
major depressive disorder (483) depressed mood (162)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
467
Tried for
major depressive disorder (394) depressed mood (154)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
429
Tried for
major depressive disorder (378) anxious mood (91)
3 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
283
Tried for
major depressive disorder (262) depressed mood (43)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
241
Tried for
anxious mood (238) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
180
Tried for
depressed mood (146) major depressive disorder (41)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (405 evaluations)
Side effects
anxious mood dry mouth 155 more
Total evaluations
463
Tried for
major depressive disorder (799) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (333 evaluations)
Side effects
dry mouth weight gain 153 more
Total evaluations
417
Tried for
major depressive disorder (587) depressed mood (109)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (293 evaluations)
Side effects
anxious mood depressed mood 57 more
Total evaluations
349
Tried for
major depressive disorder (557) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (294 evaluations)
Side effects
decreased sex drive (libido) weight gain 159 more
Total evaluations
375
Tried for
major depressive disorder (476) depressed mood (183)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (292 evaluations)
Side effects
dry mouth nausea 143 more
Total evaluations
361
Tried for
major depressive disorder (483) depressed mood (162)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (231 evaluations)
Side effects
nausea weight gain 105 more
Total evaluations
291
Tried for
major depressive disorder (394) depressed mood (154)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (235 evaluations)
Side effects
decreased sex drive (libido) weight gain 97 more
Total evaluations
283
Tried for
major depressive disorder (378) anxious mood (91)
3 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (154 evaluations)
Side effects
dry mouth decreased sex drive (libido) 82 more
Total evaluations
181
Tried for
major depressive disorder (262) depressed mood (43)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (138 evaluations)
Side effects
drowsiness sleepiness 35 more
Total evaluations
145
Tried for
anxious mood (238) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (96 evaluations)
Side effects
weight gain drowsiness 59 more
Total evaluations
135
Tried for
depressed mood (146) major depressive disorder (41)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 421
20s 4730
30s 9774
40s 14255
50s 15585
60s 8602
70+ 1736
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8731
20-29 years 3713
30-39 years 2711
40-49 years 1734
50-59 years 605
60-69 years 110
70+ years 18

Distribution of sex

Sex
Sex Proportion # of patients
Male 11551
Female 43816

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23711
Not Diagnosed 2343

These charts show data from MDD patients who have completed their condition history
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