Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
858
Tried for
major depressive disorder (812) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
631
Tried for
major depressive disorder (589) depressed mood (113)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
580
Tried for
major depressive disorder (574) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
563
Tried for
major depressive disorder (476) depressed mood (190)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
558
Tried for
major depressive disorder (490) depressed mood (165)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
486
Tried for
major depressive disorder (407) depressed mood (166)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
420
Tried for
major depressive disorder (371) anxious mood (89)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
293
Tried for
major depressive disorder (274) depressed mood (46)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
254
Tried for
anxious mood (252) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
180
Tried for
depressed mood (146) major depressive disorder (41)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (419 evaluations)
Side effects
anxious mood dry mouth 170 more
Total evaluations
482
Tried for
major depressive disorder (812) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (338 evaluations)
Side effects
dry mouth weight gain 160 more
Total evaluations
434
Tried for
major depressive disorder (589) depressed mood (113)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (300 evaluations)
Side effects
anxious mood depressed mood 53 more
Total evaluations
358
Tried for
major depressive disorder (574) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (292 evaluations)
Side effects
decreased sex drive (libido) weight gain 149 more
Total evaluations
377
Tried for
major depressive disorder (476) depressed mood (190)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (301 evaluations)
Side effects
dry mouth nausea 146 more
Total evaluations
370
Tried for
major depressive disorder (490) depressed mood (165)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (231 evaluations)
Side effects
weight gain decreased sex drive (libido) 108 more
Total evaluations
297
Tried for
major depressive disorder (407) depressed mood (166)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (238 evaluations)
Side effects
decreased sex drive (libido) weight gain 95 more
Total evaluations
284
Tried for
major depressive disorder (371) anxious mood (89)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (160 evaluations)
Side effects
dry mouth decreased sex drive (libido) 82 more
Total evaluations
188
Tried for
major depressive disorder (274) depressed mood (46)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (141 evaluations)
Side effects
drowsiness sleepiness 35 more
Total evaluations
148
Tried for
anxious mood (252) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (92 evaluations)
Side effects
weight gain drowsiness 58 more
Total evaluations
132
Tried for
depressed mood (146) major depressive disorder (41)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 433
20s 4799
30s 9681
40s 14045
50s 15010
60s 8082
70+ 1567
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8659
20-29 years 3696
30-39 years 2698
40-49 years 1721
50-59 years 603
60-69 years 110
70+ years 17

Distribution of sex

Sex
Sex Proportion # of patients
Male 11276
Female 42577

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23517
Not Diagnosed 2337

These charts show data from MDD patients who have completed their condition history
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