Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
867
Tried for
major depressive disorder (819) depressed mood (98)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
636
Tried for
major depressive disorder (592) depressed mood (113)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
572
Tried for
major depressive disorder (566) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
562
Tried for
major depressive disorder (474) depressed mood (185)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
558
Tried for
major depressive disorder (488) depressed mood (164)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
479
Tried for
major depressive disorder (403) depressed mood (159)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
431
Tried for
major depressive disorder (381) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
287
Tried for
major depressive disorder (265) depressed mood (45)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
245
Tried for
anxious mood (243) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
180
Tried for
depressed mood (146) major depressive disorder (41)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (420 evaluations)
Side effects
anxious mood dry mouth 168 more
Total evaluations
484
Tried for
major depressive disorder (819) depressed mood (98)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (340 evaluations)
Side effects
dry mouth weight gain 155 more
Total evaluations
433
Tried for
major depressive disorder (592) depressed mood (113)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (298 evaluations)
Side effects
anxious mood depressed mood 57 more
Total evaluations
354
Tried for
major depressive disorder (566) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (295 evaluations)
Side effects
decreased sex drive (libido) weight gain 156 more
Total evaluations
377
Tried for
major depressive disorder (474) depressed mood (185)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (301 evaluations)
Side effects
dry mouth nausea 145 more
Total evaluations
372
Tried for
major depressive disorder (488) depressed mood (164)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (230 evaluations)
Side effects
decreased sex drive (libido) nausea 112 more
Total evaluations
294
Tried for
major depressive disorder (403) depressed mood (159)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (239 evaluations)
Side effects
decreased sex drive (libido) weight gain 99 more
Total evaluations
287
Tried for
major depressive disorder (381) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (156 evaluations)
Side effects
dry mouth decreased sex drive (libido) 83 more
Total evaluations
184
Tried for
major depressive disorder (265) depressed mood (45)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (140 evaluations)
Side effects
drowsiness sleepiness 35 more
Total evaluations
147
Tried for
anxious mood (243) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (95 evaluations)
Side effects
weight gain drowsiness 58 more
Total evaluations
135
Tried for
depressed mood (146) major depressive disorder (41)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 435
20s 4781
30s 9786
40s 14256
50s 15526
60s 8480
70+ 1671
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8720
20-29 years 3709
30-39 years 2708
40-49 years 1728
50-59 years 605
60-69 years 110
70+ years 17

Distribution of sex

Sex
Sex Proportion # of patients
Male 11517
Female 43676

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23665
Not Diagnosed 2340

These charts show data from MDD patients who have completed their condition history
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