Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
732
Tried for
major depressive disorder (684) depressed mood (91)
7 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
528
Tried for
major depressive disorder (494) depressed mood (83)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
467
Tried for
major depressive disorder (462) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
464
Tried for
major depressive disorder (400) depressed mood (137)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
439
Tried for
major depressive disorder (385) depressed mood (119)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
378
Tried for
major depressive disorder (331) depressed mood (109)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
364
Tried for
major depressive disorder (323) anxious mood (88)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
221
Tried for
major depressive disorder (200) depressed mood (35)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
177
Tried for
anxious mood (174) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
155
Tried for
depressed mood (125) major depressive disorder (35)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (363 evaluations)
Side effects
anxious mood dry mouth 150 more
Total evaluations
435
Tried for
major depressive disorder (684) depressed mood (91)
7 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (282 evaluations)
Side effects
dry mouth weight gain 134 more
Total evaluations
345
Tried for
major depressive disorder (494) depressed mood (83)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (252 evaluations)
Side effects
anxious mood flashbacks 50 more
Total evaluations
299
Tried for
major depressive disorder (462) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (268 evaluations)
Side effects
decreased sex drive (libido) weight gain 138 more
Total evaluations
324
Tried for
major depressive disorder (400) depressed mood (137)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (244 evaluations)
Side effects
nausea dry mouth 126 more
Total evaluations
294
Tried for
major depressive disorder (385) depressed mood (119)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (204 evaluations)
Side effects
nausea decreased sex drive (libido) 99 more
Total evaluations
243
Tried for
major depressive disorder (331) depressed mood (109)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (176 evaluations)
Side effects
decreased sex drive (libido) weight gain 101 more
Total evaluations
209
Tried for
major depressive disorder (323) anxious mood (88)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (113 evaluations)
Side effects
nausea dry mouth 58 more
Total evaluations
133
Tried for
major depressive disorder (200) depressed mood (35)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (91 evaluations)
Side effects
drowsiness tiredness 20 more
Total evaluations
97
Tried for
anxious mood (174) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (84 evaluations)
Side effects
weight gain drowsiness 56 more
Total evaluations
121
Tried for
depressed mood (125) major depressive disorder (35)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 339
20s 4364
30s 9541
40s 14349
50s 16754
60s 10321
70+ 2306
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8805
20-29 years 3721
30-39 years 2719
40-49 years 1746
50-59 years 609
60-69 years 114
70+ years 19

Distribution of sex

Sex
Sex Proportion # of patients
Male 12016
Female 46265

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23861
Not Diagnosed 2333

These charts show data from MDD patients who have completed their condition history
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