Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
856
Tried for
major depressive disorder (810) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
629
Tried for
major depressive disorder (586) depressed mood (114)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
582
Tried for
major depressive disorder (576) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
567
Tried for
major depressive disorder (479) depressed mood (192)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
558
Tried for
major depressive disorder (490) depressed mood (166)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
486
Tried for
major depressive disorder (407) depressed mood (166)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
422
Tried for
major depressive disorder (373) anxious mood (89)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
293
Tried for
major depressive disorder (273) depressed mood (47)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
256
Tried for
anxious mood (254) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
180
Tried for
depressed mood (145) major depressive disorder (42)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (416 evaluations)
Side effects
anxious mood dry mouth 164 more
Total evaluations
478
Tried for
major depressive disorder (810) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (335 evaluations)
Side effects
dry mouth weight gain 159 more
Total evaluations
430
Tried for
major depressive disorder (586) depressed mood (114)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (296 evaluations)
Side effects
anxious mood depressed mood 53 more
Total evaluations
355
Tried for
major depressive disorder (576) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (295 evaluations)
Side effects
decreased sex drive (libido) weight gain 151 more
Total evaluations
380
Tried for
major depressive disorder (479) depressed mood (192)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (303 evaluations)
Side effects
dry mouth weight gain 147 more
Total evaluations
370
Tried for
major depressive disorder (490) depressed mood (166)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (234 evaluations)
Side effects
weight gain decreased sex drive (libido) 108 more
Total evaluations
300
Tried for
major depressive disorder (407) depressed mood (166)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (237 evaluations)
Side effects
decreased sex drive (libido) weight gain 97 more
Total evaluations
284
Tried for
major depressive disorder (373) anxious mood (89)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (160 evaluations)
Side effects
dry mouth decreased sex drive (libido) 82 more
Total evaluations
189
Tried for
major depressive disorder (273) depressed mood (47)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (142 evaluations)
Side effects
drowsiness sleepiness 37 more
Total evaluations
149
Tried for
anxious mood (254) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (95 evaluations)
Side effects
weight gain nausea 59 more
Total evaluations
136
Tried for
depressed mood (145) major depressive disorder (42)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 434
20s 4789
30s 9649
40s 13962
50s 14827
60s 7918
70+ 1516
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8623
20-29 years 3689
30-39 years 2689
40-49 years 1716
50-59 years 601
60-69 years 110
70+ years 17

Distribution of sex

Sex
Sex Proportion # of patients
Male 11185
Female 42139

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23425
Not Diagnosed 2336

These charts show data from MDD patients who have completed their condition history
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