Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
737
Tried for
major depressive disorder (697) depressed mood (85)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
532
Tried for
major depressive disorder (498) depressed mood (84)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
493
Tried for
major depressive disorder (487) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
479
Tried for
major depressive disorder (410) depressed mood (148)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
455
Tried for
major depressive disorder (397) depressed mood (130)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
388
Tried for
major depressive disorder (334) depressed mood (118)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
381
Tried for
major depressive disorder (336) anxious mood (84)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
229
Tried for
major depressive disorder (208) depressed mood (39)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
185
Tried for
anxious mood (182) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
162
Tried for
depressed mood (132) major depressive disorder (35)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (364 evaluations)
Side effects
anxious mood dry mouth 148 more
Total evaluations
427
Tried for
major depressive disorder (697) depressed mood (86)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (282 evaluations)
Side effects
weight gain dry mouth 138 more
Total evaluations
346
Tried for
major depressive disorder (498) depressed mood (84)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (259 evaluations)
Side effects
anxious mood flashbacks 54 more
Total evaluations
309
Tried for
major depressive disorder (487) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (266 evaluations)
Side effects
decreased sex drive (libido) weight gain 145 more
Total evaluations
329
Tried for
major depressive disorder (410) depressed mood (148)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (244 evaluations)
Side effects
dry mouth nausea 130 more
Total evaluations
300
Tried for
major depressive disorder (397) depressed mood (130)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (204 evaluations)
Side effects
decreased sex drive (libido) nausea 100 more
Total evaluations
250
Tried for
major depressive disorder (335) depressed mood (118)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (213 evaluations)
Side effects
decreased sex drive (libido) weight gain 103 more
Total evaluations
256
Tried for
major depressive disorder (336) anxious mood (84)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (119 evaluations)
Side effects
dry mouth decreased sex drive (libido) 69 more
Total evaluations
145
Tried for
major depressive disorder (208) depressed mood (39)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (105 evaluations)
Side effects
drowsiness sleepiness 24 more
Total evaluations
112
Tried for
anxious mood (182) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (88 evaluations)
Side effects
weight gain drowsiness 55 more
Total evaluations
124
Tried for
depressed mood (132) major depressive disorder (35)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 345
20s 4497
30s 9568
40s 14096
50s 15739
60s 9196
70+ 1968
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8743
20-29 years 3703
30-39 years 2707
40-49 years 1735
50-59 years 604
60-69 years 113
70+ years 18

Distribution of sex

Sex
Sex Proportion # of patients
Male 11613
Female 44067

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23720
Not Diagnosed 2334

These charts show data from MDD patients who have completed their condition history
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