Major depressive disorder

We’re all in this for good.

By sharing your stories and data, you will:
  • help each other live better and uncover the best ways to manage your health today
  • help researchers shorten the path to new treatments tomorrow

How much good can your data do? A whole lot, as co-founder Jamie Heywood explains in this video.

What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
611
Tried for
major depressive disorder (569) depressed mood (79)
7 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
412
Tried for
major depressive disorder (407) anxious mood (8)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
411
Tried for
major depressive disorder (380) depressed mood (71)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
377
Tried for
major depressive disorder (332) depressed mood (106)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
364
Tried for
major depressive disorder (326) depressed mood (97)
4 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
308
Tried for
major depressive disorder (273) anxious mood (79)
2 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
303
Tried for
major depressive disorder (267) depressed mood (84)
3 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
171
Tried for
major depressive disorder (156) depressed mood (28)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
136
Tried for
depressed mood (108) major depressive disorder (33)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
136
Tried for
anxious mood (132) major depressive disorder (3)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (306 evaluations)
Side effects
dry mouth anxious mood 144 more
Total evaluations
371
Tried for
major depressive disorder (569) depressed mood (79)
7 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (218 evaluations)
Side effects
anxious mood flashbacks 41 more
Total evaluations
260
Tried for
major depressive disorder (407) anxious mood (8)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (219 evaluations)
Side effects
dry mouth weight gain 128 more
Total evaluations
275
Tried for
major depressive disorder (380) depressed mood (71)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (227 evaluations)
Side effects
decreased sex drive (libido) weight gain 117 more
Total evaluations
271
Tried for
major depressive disorder (332) depressed mood (106)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (227 evaluations)
Side effects
nausea dry mouth 115 more
Total evaluations
263
Tried for
major depressive disorder (326) depressed mood (97)
4 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (159 evaluations)
Side effects
decreased sex drive (libido) dry mouth 92 more
Total evaluations
193
Tried for
major depressive disorder (273) anxious mood (79)
2 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (167 evaluations)
Side effects
nausea decreased sex drive (libido) 82 more
Total evaluations
198
Tried for
major depressive disorder (267) depressed mood (84)
3 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (94 evaluations)
Side effects
nausea weight gain 46 more
Total evaluations
110
Tried for
major depressive disorder (156) depressed mood (28)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (71 evaluations)
Side effects
weight gain drowsiness 55 more
Total evaluations
109
Tried for
depressed mood (108) major depressive disorder (33)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (68 evaluations)
Side effects
drowsiness sleepiness 18 more
Total evaluations
75
Tried for
anxious mood (132) major depressive disorder (3)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?

  • 22 new patients joined this month
  • 31641 say MDD is their primary condition

Age
Age Proportion # of patients
<20 306
20s 4231
30s 9408
40s 14216
50s 16821
60s 10620
70+ 2459
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8811
20-29 years 3723
30-39 years 2724
40-49 years 1748
50-59 years 609
60-69 years 114
70+ years 19

Distribution of sex

Sex
Sex Proportion # of patients
Male 12038
Female 46328

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23877
Not Diagnosed 2332

These charts show data from MDD patients who have completed their condition history
Last updated: