Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
744
Tried for
major depressive disorder (702) depressed mood (87)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
537
Tried for
major depressive disorder (503) depressed mood (85)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
502
Tried for
major depressive disorder (496) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
489
Tried for
major depressive disorder (419) depressed mood (153)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
460
Tried for
major depressive disorder (403) depressed mood (131)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
386
Tried for
major depressive disorder (330) depressed mood (120)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
380
Tried for
major depressive disorder (334) anxious mood (82)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
232
Tried for
major depressive disorder (210) depressed mood (40)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
190
Tried for
anxious mood (187) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
160
Tried for
depressed mood (130) major depressive disorder (35)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (369 evaluations)
Side effects
anxious mood dry mouth 148 more
Total evaluations
433
Tried for
major depressive disorder (702) depressed mood (87)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (281 evaluations)
Side effects
weight gain dry mouth 140 more
Total evaluations
347
Tried for
major depressive disorder (503) depressed mood (85)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (264 evaluations)
Side effects
anxious mood flashbacks 54 more
Total evaluations
315
Tried for
major depressive disorder (496) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (274 evaluations)
Side effects
decreased sex drive (libido) weight gain 149 more
Total evaluations
337
Tried for
major depressive disorder (419) depressed mood (153)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (250 evaluations)
Side effects
dry mouth nausea 131 more
Total evaluations
306
Tried for
major depressive disorder (403) depressed mood (131)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (204 evaluations)
Side effects
decreased sex drive (libido) nausea 100 more
Total evaluations
250
Tried for
major depressive disorder (330) depressed mood (120)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (212 evaluations)
Side effects
decreased sex drive (libido) weight gain 96 more
Total evaluations
255
Tried for
major depressive disorder (334) anxious mood (82)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (121 evaluations)
Side effects
dry mouth decreased sex drive (libido) 72 more
Total evaluations
148
Tried for
major depressive disorder (210) depressed mood (40)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (116 evaluations)
Side effects
drowsiness sleepiness 30 more
Total evaluations
123
Tried for
anxious mood (187) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (89 evaluations)
Side effects
weight gain drowsiness 55 more
Total evaluations
125
Tried for
depressed mood (130) major depressive disorder (35)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 374
20s 4571
30s 9643
40s 14168
50s 15648
60s 8983
70+ 1885
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8734
20-29 years 3701
30-39 years 2708
40-49 years 1737
50-59 years 603
60-69 years 112
70+ years 18

Distribution of sex

Sex
Sex Proportion # of patients
Male 11584
Female 43959

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23699
Not Diagnosed 2337

These charts show data from MDD patients who have completed their condition history
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