Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
841
Tried for
major depressive disorder (795) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
622
Tried for
major depressive disorder (580) depressed mood (108)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
554
Tried for
major depressive disorder (483) depressed mood (161)
5 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
553
Tried for
major depressive disorder (470) depressed mood (180)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
547
Tried for
major depressive disorder (541) anxious mood (10)
6 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
460
Tried for
major depressive disorder (388) depressed mood (151)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
423
Tried for
major depressive disorder (374) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
276
Tried for
major depressive disorder (254) depressed mood (43)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
237
Tried for
anxious mood (234) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
181
Tried for
depressed mood (147) major depressive disorder (40)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (399 evaluations)
Side effects
anxious mood dry mouth 156 more
Total evaluations
461
Tried for
major depressive disorder (795) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (329 evaluations)
Side effects
dry mouth weight gain 150 more
Total evaluations
411
Tried for
major depressive disorder (580) depressed mood (108)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (294 evaluations)
Side effects
dry mouth nausea 143 more
Total evaluations
361
Tried for
major depressive disorder (483) depressed mood (161)
5 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (293 evaluations)
Side effects
decreased sex drive (libido) weight gain 159 more
Total evaluations
372
Tried for
major depressive disorder (470) depressed mood (180)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (283 evaluations)
Side effects
anxious mood depressed mood 56 more
Total evaluations
339
Tried for
major depressive disorder (541) anxious mood (10)
6 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (228 evaluations)
Side effects
nausea weight gain 104 more
Total evaluations
287
Tried for
major depressive disorder (388) depressed mood (151)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (231 evaluations)
Side effects
decreased sex drive (libido) weight gain 97 more
Total evaluations
278
Tried for
major depressive disorder (374) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (150 evaluations)
Side effects
dry mouth decreased sex drive (libido) 79 more
Total evaluations
178
Tried for
major depressive disorder (254) depressed mood (43)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (136 evaluations)
Side effects
drowsiness sleepiness 35 more
Total evaluations
143
Tried for
anxious mood (234) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (98 evaluations)
Side effects
weight gain drowsiness 57 more
Total evaluations
137
Tried for
depressed mood (147) major depressive disorder (40)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 400
20s 4662
30s 9762
40s 14219
50s 15643
60s 8754
70+ 1789
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8748
20-29 years 3713
30-39 years 2710
40-49 years 1734
50-59 years 605
60-69 years 112
70+ years 18

Distribution of sex

Sex
Sex Proportion # of patients
Male 11576
Female 43919

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23733
Not Diagnosed 2344

These charts show data from MDD patients who have completed their condition history
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