Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
738
Tried for
major depressive disorder (695) depressed mood (88)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
529
Tried for
major depressive disorder (494) depressed mood (84)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
488
Tried for
major depressive disorder (482) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
466
Tried for
major depressive disorder (399) depressed mood (143)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
445
Tried for
major depressive disorder (388) depressed mood (127)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
388
Tried for
major depressive disorder (336) depressed mood (115)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
378
Tried for
major depressive disorder (333) anxious mood (85)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
225
Tried for
major depressive disorder (202) depressed mood (38)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
185
Tried for
anxious mood (182) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
158
Tried for
depressed mood (129) major depressive disorder (34)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (360 evaluations)
Side effects
anxious mood dry mouth 147 more
Total evaluations
425
Tried for
major depressive disorder (695) depressed mood (88)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (279 evaluations)
Side effects
weight gain dry mouth 138 more
Total evaluations
342
Tried for
major depressive disorder (493) depressed mood (83)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (256 evaluations)
Side effects
anxious mood flashbacks 54 more
Total evaluations
305
Tried for
major depressive disorder (482) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (259 evaluations)
Side effects
decreased sex drive (libido) weight gain 139 more
Total evaluations
320
Tried for
major depressive disorder (399) depressed mood (143)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (242 evaluations)
Side effects
nausea dry mouth 132 more
Total evaluations
298
Tried for
major depressive disorder (388) depressed mood (127)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (204 evaluations)
Side effects
decreased sex drive (libido) nausea 99 more
Total evaluations
246
Tried for
major depressive disorder (336) depressed mood (115)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (210 evaluations)
Side effects
decreased sex drive (libido) weight gain 103 more
Total evaluations
249
Tried for
major depressive disorder (333) anxious mood (85)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (113 evaluations)
Side effects
decreased sex drive (libido) nausea 60 more
Total evaluations
134
Tried for
major depressive disorder (202) depressed mood (38)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (100 evaluations)
Side effects
drowsiness sleepiness 22 more
Total evaluations
107
Tried for
anxious mood (182) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (83 evaluations)
Side effects
weight gain drowsiness 54 more
Total evaluations
119
Tried for
depressed mood (129) major depressive disorder (34)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 338
20s 4450
30s 9533
40s 14121
50s 15903
60s 9418
70+ 2042
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8760
20-29 years 3707
30-39 years 2708
40-49 years 1736
50-59 years 604
60-69 years 114
70+ years 20

Distribution of sex

Sex
Sex Proportion # of patients
Male 11688
Female 44394

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23753
Not Diagnosed 2334

These charts show data from MDD patients who have completed their condition history
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