Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
732
Tried for
major depressive disorder (687) depressed mood (88)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
528
Tried for
major depressive disorder (494) depressed mood (83)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
478
Tried for
major depressive disorder (473) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
465
Tried for
major depressive disorder (401) depressed mood (140)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
440
Tried for
major depressive disorder (385) depressed mood (124)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
385
Tried for
major depressive disorder (335) depressed mood (114)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
370
Tried for
major depressive disorder (326) anxious mood (86)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
224
Tried for
major depressive disorder (201) depressed mood (37)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
181
Tried for
anxious mood (178) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
159
Tried for
depressed mood (132) major depressive disorder (32)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (361 evaluations)
Side effects
anxious mood dry mouth 148 more
Total evaluations
429
Tried for
major depressive disorder (687) depressed mood (88)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (277 evaluations)
Side effects
weight gain dry mouth 136 more
Total evaluations
339
Tried for
major depressive disorder (494) depressed mood (83)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (255 evaluations)
Side effects
anxious mood flashbacks 52 more
Total evaluations
303
Tried for
major depressive disorder (473) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (261 evaluations)
Side effects
decreased sex drive (libido) weight gain 134 more
Total evaluations
319
Tried for
major depressive disorder (401) depressed mood (140)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (234 evaluations)
Side effects
nausea dry mouth 131 more
Total evaluations
287
Tried for
major depressive disorder (385) depressed mood (124)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (204 evaluations)
Side effects
nausea decreased sex drive (libido) 100 more
Total evaluations
245
Tried for
major depressive disorder (335) depressed mood (114)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (187 evaluations)
Side effects
decreased sex drive (libido) weight gain 104 more
Total evaluations
225
Tried for
major depressive disorder (326) anxious mood (86)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (111 evaluations)
Side effects
decreased sex drive (libido) nausea 60 more
Total evaluations
132
Tried for
major depressive disorder (201) depressed mood (37)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (92 evaluations)
Side effects
drowsiness tiredness 22 more
Total evaluations
98
Tried for
anxious mood (178) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (85 evaluations)
Side effects
weight gain drowsiness 51 more
Total evaluations
119
Tried for
depressed mood (132) major depressive disorder (32)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 333
20s 4419
30s 9554
40s 14243
50s 16356
60s 9863
70+ 2169
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8780
20-29 years 3717
30-39 years 2712
40-49 years 1744
50-59 years 607
60-69 years 114
70+ years 19

Distribution of sex

Sex
Sex Proportion # of patients
Male 11818
Female 45409

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23804
Not Diagnosed 2334

These charts show data from MDD patients who have completed their condition history
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