What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,981 2,977
Depressed mood 1,969 1,123
Major Depressive Disorder 1,709 1,039
Generalized Anxiety Disorder 733 518
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 688 371
Pain 519 294

Show all 351 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 882
Moderate 944
Mild 1,092
None 1,593

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 288
Nausea 279
Dizziness 158
Dry mouth 156
Sex drive (libido) decreased 155
Sweating increased 99

Show all 723 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 547
30 mg daily 224
120 mg daily 133
60 mg twice daily 104
90 mg daily 101
20 mg daily 79
30 mg twice daily 53
40 mg daily 42
120 mg twice daily 25
20 mg twice daily 13

See all 58 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1673
Did not seem to work 1456
Doctor's advice 542
Expense 431
Other 410
Personal research 164
Change in health plan coverage 153
Course of treatment ended 63
See all 3294 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 8
1 - 6 months 106
6 months - 1 year 212
1 - 2 years 254
2 - 5 years 381
5 - 10 years 356
10 years or more 146

Stopped taking Duloxetine

Duration Patients
Less than 1 month 714
1 - 6 months 937
6 months - 1 year 538
1 - 2 years 471
2 - 5 years 485
5 - 10 years 133
10 years or more 32
Adherence
Adherence Evaluations
Always 3791
Usually 396
Sometimes 64
Never taken as prescribed 260
Burden
Burden Evaluations
Very hard to take 279
Somewhat hard to take 348
A little hard to take 529
Not at all hard to take 3355
Cost per month
Cost per month Evaluations
$200+ 122
$100-199 187
$50-99 420
$25-49 659
< $25 1433
Not specified 1690

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 129
Fluoxetine (Prozac) 103
Venlafaxine (Effexor XR) 98
Sertraline (Zoloft) 84
Citalopram (Celexa) 78

Show all 69 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 64
Venlafaxine (Effexor XR) 57
Gabapentin (Neurontin) 42
Bupropion (Wellbutrin XL) 32
Sertraline (Zoloft) 31

Show all 69 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,655 members have decided to share their profiles only with other members of PatientsLikeMe.

missgriffith85
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missgriffith85
Gender: F
Data Quality: 1 star
Pain: Some
Fatigue: Some
Sleep: None
Stiffness: Little
function: All
external_stress: Little
Stickman: little
Description:F32y
FM:7y Dx
I am: g
I have:
Fibromyalgia

See missgriffith85's full Duloxetine history

Feb 15, 2016 (Started Apr 06, 2012)

  • Effectiveness
    Slight (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Sometimes
  • Burden
    Very hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

Jan 31, 2016 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 120 mg Daily

May 15, 2013 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Moderate (Dry mouth, Indigestion)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I took this for Fibromyalgia and it is an SSRI so it lifts you mood a bit after you take it for an extended period of time.
Cost: $200+ monthly

Feb 6, 2013 (Started Apr 06, 2012)

  • Effectiveness
    Can’t tell (for Generalized Anxiety Disorder)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $200+ monthly

Dec 11, 2012 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $200+ monthly

Nov 30, 2012 (Started Apr 06, 2012)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: It helps with Anxiety.
Cost: $200+ monthly

  • 1 helpful mark
futterfly
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futterfly
Gender: F
Data Quality: 1 star
Depression: 1
Mania: 1
Emotional: 1
Anxiety: 1
Compulsion: 0
External Stress: Moderate
44 F
Function: High
Distress: Low
I am: b
I have:
Bipolar II

See futterfly's full Duloxetine history

Dec 8, 2015 (Started Jul 01, 2014)

  • Effectiveness
    Major (for Major Depressive Disorder)
  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 90 mg Daily
Advice & Tips: Do not skip doses. If you go more than 2 or 3 days you will start feeling like you have the flu.
Cost: $50-99 monthly

  • 1 helpful mark
vniagara
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vniagara
Gender: M
Data Quality: 0 stars
Pain: All
Fatigue: Most
Sleep: Some
Stiffness: All
function: Little
external_stress: Some
Stickman: most
Description:M43y
FM:14y Dx
I have:
Fibromyalgia

See vniagara's full Duloxetine history

Oct 12, 2015 (Started Sep 09, 2010)

  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Somewhat hard to take
Dosage: 90 mg Daily
Advice & Tips: Hopefully this medication will help some people with Fibromyalgia however it does not seem to help me at all.

  • 0 helpful marks
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine