What is Duloxetine?

Category: Prescription Drugs

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,199 2,398
Depressed mood 1,849 1,023
Major Depressive Disorder 1,346 785
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 679 354
Generalized Anxiety Disorder 653 464
Pain 500 280

Show all 321 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 760
Moderate 809
Mild 911
None 1,226

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 234
Weight gain 220
Sex drive (libido) decreased 151
Dizziness 138
Dry mouth 124
Sweating increased 96

Show all 655 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 248
30 mg daily 116
120 mg daily 64
90 mg daily 50
60 mg twice daily 33
20 mg daily 32
30 mg twice daily 20
40 mg daily 11
120 mg twice daily 5
20 mg twice daily 3

See all 35 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1555
Did not seem to work 1311
Doctor's advice 504
Expense 409
Other 380
Personal research 146
Change in health plan coverage 141
Course of treatment ended 62
See all 3017 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 8
1 - 6 months 46
6 months - 1 year 40
1 - 2 years 91
2 - 5 years 177
5 - 10 years 196
10 years or more 63

Stopped taking Duloxetine

Duration Patients
Less than 1 month 635
1 - 6 months 901
6 months - 1 year 484
1 - 2 years 430
2 - 5 years 438
5 - 10 years 118
10 years or more 26
Adherence
Adherence Evaluations
Always 3135
Usually 330
Sometimes 55
Never taken as prescribed 186
Burden
Burden Evaluations
Very hard to take 228
Somewhat hard to take 292
A little hard to take 453
Not at all hard to take 2733
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 169
$50-99 386
$25-49 580
< $25 1066
Not specified 1389

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 61
Venlafaxine (Effexor XR) 56
Fluoxetine (Prozac) 52
Escitalopram (Lexapro) 47
Sertraline (Zoloft) 46

Show all 53 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 42
Pregabalin (Lyrica) 30
Bupropion (Wellbutrin XL) 23
Sertraline (Zoloft) 22
Gabapentin (Neurontin) 21

Show all 51 treatments patients report switching to

Last updated:

317 patient evaluations for Duloxetine

2,940 members have decided to share their profiles only with other members of PatientsLikeMe.

missgriffith85
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missgriffith85
Gender: F
Data Quality: 1 star
Pain: Some
Fatigue: Some
Sleep: None
Stiffness: Little
function: All
external_stress: Little
Stickman: little
Description:F31y
FM:6y Dx
I am: g
I have:
Fibromyalgia

See missgriffith85's full Duloxetine history

Feb 15, 2016 (Started Apr 06, 2012)

  • Effectiveness
    Slight (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Sometimes
  • Burden
    Very hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

Jan 31, 2016 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 120 mg Daily

May 15, 2013 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Moderate (Dry mouth, Indigestion)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I took this for Fibromyalgia and it is an SSRI so it lifts you mood a bit after you take it for an extended period of time.
Cost: $200+ monthly

Feb 6, 2013 (Started Apr 06, 2012)

  • Effectiveness
    Can’t tell (for Generalized Anxiety Disorder)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $200+ monthly

Dec 11, 2012 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $200+ monthly

Nov 30, 2012 (Started Apr 06, 2012)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: It helps with Anxiety.
Cost: $200+ monthly

  • 1 helpful mark
futterfly
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futterfly
Gender: F
Data Quality: 1 star
Depression: 1
Mania: 1
Emotional: 1
Anxiety: 1
Compulsion: 0
External Stress: Moderate
43 F
Function: High
Distress: Low
I am: b
I have:
Bipolar II

See futterfly's full Duloxetine history

Dec 8, 2015 (Started Jul 01, 2014)

  • Effectiveness
    Major (for Major Depressive Disorder)
  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 90 mg Daily
Advice & Tips: Do not skip doses. If you go more than 2 or 3 days you will start feeling like you have the flu.
Cost: $50-99 monthly

  • 0 helpful marks
vniagara
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vniagara
Gender: M
Data Quality: 0 stars
Pain: All
Fatigue: Most
Sleep: Some
Stiffness: All
function: Little
external_stress: Some
Stickman: most
Description:M43y
FM:14y Dx
I have:
Fibromyalgia

See vniagara's full Duloxetine history

Oct 12, 2015 (Started Sep 09, 2010)

  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Somewhat hard to take
Dosage: 90 mg Daily
Advice & Tips: Hopefully this medication will help some people with Fibromyalgia however it does not seem to help me at all.

  • 0 helpful marks
Last updated:
Showing 3 of 317 patient evaluations for Duloxetine