What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,587 2,676
Depressed mood 1,902 1,066
Major Depressive Disorder 1,491 892
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 681 363
Generalized Anxiety Disorder 674 482
Pain 510 287

Show all 336 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 819
Moderate 865
Mild 997
None 1,407

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 253
Weight gain 246
Dizziness 153
Sex drive (libido) decreased 152
Dry mouth 140
Sweating increased 98

Show all 688 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 390
30 mg daily 166
120 mg daily 88
90 mg daily 72
60 mg twice daily 70
20 mg daily 51
30 mg twice daily 37
40 mg daily 23
120 mg twice daily 16
20 mg twice daily 6

See all 46 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1620
Did not seem to work 1382
Doctor's advice 521
Expense 420
Other 388
Personal research 149
Change in health plan coverage 148
Course of treatment ended 63
See all 3146 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 7
1 - 6 months 75
6 months - 1 year 120
1 - 2 years 167
2 - 5 years 254
5 - 10 years 267
10 years or more 112

Stopped taking Duloxetine

Duration Patients
Less than 1 month 681
1 - 6 months 917
6 months - 1 year 512
1 - 2 years 448
2 - 5 years 454
5 - 10 years 123
10 years or more 27
Adherence
Adherence Evaluations
Always 3442
Usually 361
Sometimes 60
Never taken as prescribed 225
Burden
Burden Evaluations
Very hard to take 255
Somewhat hard to take 319
A little hard to take 492
Not at all hard to take 3022
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 174
$50-99 401
$25-49 615
< $25 1254
Not specified 1528

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 104
Fluoxetine (Prozac) 80
Venlafaxine (Effexor XR) 75
Sertraline (Zoloft) 67
Citalopram (Celexa) 58

Show all 59 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 47
Pregabalin (Lyrica) 45
Gabapentin (Neurontin) 30
Bupropion (Wellbutrin XL) 27
Sertraline (Zoloft) 25

Show all 62 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,288 members have decided to share their profiles only with other members of PatientsLikeMe.

missgriffith85
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missgriffith85
Gender: F
Data Quality: 1 star
Pain: Some
Fatigue: Some
Sleep: None
Stiffness: Little
function: All
external_stress: Little
Stickman: little
Description:F32y
FM:7y Dx
I am: g
I have:
Fibromyalgia

See missgriffith85's full Duloxetine history

Feb 15, 2016 (Started Apr 06, 2012)

  • Effectiveness
    Slight (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Sometimes
  • Burden
    Very hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

Jan 31, 2016 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 120 mg Daily

May 15, 2013 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Moderate (Dry mouth, Indigestion)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I took this for Fibromyalgia and it is an SSRI so it lifts you mood a bit after you take it for an extended period of time.
Cost: $200+ monthly

Feb 6, 2013 (Started Apr 06, 2012)

  • Effectiveness
    Can’t tell (for Generalized Anxiety Disorder)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $200+ monthly

Dec 11, 2012 (Started Apr 06, 2012)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $200+ monthly

Nov 30, 2012 (Started Apr 06, 2012)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Side effects
    Mild (Dry mouth, Indigestion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: It helps with Anxiety.
Cost: $200+ monthly

  • 1 helpful mark
futterfly
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futterfly
Gender: F
Data Quality: 1 star
Depression: 1
Mania: 1
Emotional: 1
Anxiety: 1
Compulsion: 0
External Stress: Moderate
43 F
Function: High
Distress: Low
I am: b
I have:
Bipolar II

See futterfly's full Duloxetine history

Dec 8, 2015 (Started Jul 01, 2014)

  • Effectiveness
    Major (for Major Depressive Disorder)
  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 90 mg Daily
Advice & Tips: Do not skip doses. If you go more than 2 or 3 days you will start feeling like you have the flu.
Cost: $50-99 monthly

  • 0 helpful marks
vniagara
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vniagara
Gender: M
Data Quality: 0 stars
Pain: All
Fatigue: Most
Sleep: Some
Stiffness: All
function: Little
external_stress: Some
Stickman: most
Description:M43y
FM:14y Dx
I have:
Fibromyalgia

See vniagara's full Duloxetine history

Oct 12, 2015 (Started Sep 09, 2010)

  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Somewhat hard to take
Dosage: 90 mg Daily
Advice & Tips: Hopefully this medication will help some people with Fibromyalgia however it does not seem to help me at all.

  • 0 helpful marks
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine