What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,374 3,224
Depressed mood 2,080 1,236
Major depressive disorder 1,935 1,180
Generalized anxiety disorder 800 572
Myalgic encephalomyelitis/chronic fatigue syndrome 692 384
Pain 536 317

Show all 325 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 933
Moderate 1,022
Mild 1,153
None 1,784

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 336
Nausea 286
Decreased sex drive (libido) 185
Dry mouth 169
Dizziness 159
Sweating increased 101

Show all 592 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 390
30 mg daily 140
120 mg daily 127
90 mg daily 70
60 mg twice daily 65
20 mg daily 48
30 mg twice daily 23
40 mg daily 16
20 mg twice daily 13
120 mg twice daily 12

See all 37 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1756
Did not seem to work 1556
Doctor's advice 590
Expense 444
Other 435
Personal research 177
Change in health plan coverage 160
Course of treatment ended 70
See all 3495 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 3
1 - 6 months 32
6 months - 1 year 38
1 - 2 years 116
2 - 5 years 292
5 - 10 years 323
10 years or more 166

Stopped taking Duloxetine

Duration Patients
Less than 1 month 815
1 - 6 months 934
6 months - 1 year 551
1 - 2 years 496
2 - 5 years 522
5 - 10 years 156
10 years or more 38
Adherence
Adherence Evaluations
Always 4094
Usually 436
Sometimes 75
Never taken as prescribed 287
Burden
Burden Evaluations
Very hard to take 303
Somewhat hard to take 370
A little hard to take 577
Not at all hard to take 3642
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 190
$50-99 433
$25-49 690
< $25 1583
Not specified 1870

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 152
Fluoxetine (Prozac) 134
Venlafaxine (Effexor XR) 123
Sertraline (Zoloft) 116
Citalopram (Celexa) 99

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 78
Venlafaxine (Effexor XR) 71
Gabapentin (Neurontin) 59
Escitalopram (Lexapro) 39
Bupropion (Wellbutrin XL) 37

Show all 78 treatments patients report switching to

Last updated:

320 patient evaluations for Duloxetine

Aug 31, 2016 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly
Side effects: fuzzy thinking

Jul 29, 2011 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly
Side effects: fuzzy thinking

Jan 26, 2010 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    Mild (fuzzy thinking)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Decided that the fuzzy head feeling from it might not be worth the benefit. I will go off for a few weeks and see if it was making a big emough difference in my pain in hands to warrant going back on.
Cost: $50-99 monthly
Side effects: fuzzy thinking

Jan 12, 2010 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    Mild (fuzzy thinking)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am weaning off this drug as it doesn't seem to be helping alot
Cost: $50-99 monthly
Side effects: fuzzy thinking

Dec 4, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $50-99 monthly
Side effects: fuzzy thinking

Oct 29, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly
Side effects: fuzzy thinking

Sep 23, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly
Side effects: fuzzy thinking

  • 0 helpful marks

Jul 6, 2016 (Started Aug 08, 2009)

  • Effectiveness
    Moderate (for fibromyalgia)
  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I didn't think Cymbalta helped my pain, so I weaned off of it.  I couldn't believe how much worse my pain was without Cymbalta, so I went back to taking it daily.  I am not sure that it's the best treatment for my depression though!
Cost: $25-49 monthly

  • 0 helpful marks

May 29, 2016 (Started Jul 15, 2002)

  • Effectiveness
    Can't tell (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Can't tell (for fibromyalgia)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily

Mar 1, 2011 (Started Jul 15, 2002)

  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Slight (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: For depression (which occured years before FMS or CFS), it took me several different depression meds to find out one that helped or didn't cause undesirably side effects. Cymbalta works for me. Don't give up if the firstbtwo or three don't work.

  • 1 helpful mark
Last updated:
Showing 3 of 320 patient evaluations for Duloxetine