What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,325 3,184
Depressed mood 2,063 1,211
Major depressive disorder 1,889 1,143
Generalized anxiety disorder 792 558
Myalgic encephalomyelitis/chronic fatigue syndrome 696 388
Pain 532 313

Show all 326 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
923
Moderate
1,007
Mild
1,137
None
1,737

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 330
Nausea 287
Dry mouth 165
Dizziness 158
Decreased sex drive (libido) 153
Sweating increased 100

Show all 746 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 447
30 mg daily 173
120 mg daily 119
90 mg daily 76
60 mg twice daily 73
20 mg daily 68
30 mg twice daily 30
40 mg daily 22
20 mg twice daily 13
120 mg twice daily 13

See all 41 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1744
Did not seem to work 1536
Doctor's advice 582
Expense 442
Other 431
Personal research 170
Change in health plan coverage 159
Course of treatment ended 69
See all 3464 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 4
1 - 6 months 43
6 months - 1 year 98
1 - 2 years 162
2 - 5 years 320
5 - 10 years 337
10 years or more 149

Stopped taking Duloxetine

Duration Patients
Less than 1 month 810
1 - 6 months 931
6 months - 1 year 542
1 - 2 years 494
2 - 5 years 512
5 - 10 years 155
10 years or more 35
Adherence
Adherence Evaluations
Always 4023
Usually 424
Sometimes 74
Never taken as prescribed 283
Burden
Burden Evaluations
Very hard to take 299
Somewhat hard to take 367
A little hard to take 566
Not at all hard to take 3572
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 191
$50-99 430
$25-49 689
< $25 1552
Not specified 1816

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 153
Fluoxetine (Prozac) 128
Venlafaxine (Effexor XR) 121
Sertraline (Zoloft) 109
Citalopram (Celexa) 97

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 79
Venlafaxine (Effexor XR) 68
Gabapentin (Neurontin) 58
Escitalopram (Lexapro) 36
Sertraline (Zoloft) 36

Show all 76 treatments patients report switching to

Last updated:

319 patient evaluations for Duloxetine

Oct 15, 2016 (Started Jul 01, 2010)

  • Effectiveness
    Can't tell (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Can't tell (for generalized anxiety disorder)
  • Effectiveness
    Can't tell (for fibromyalgia)
  • Effectiveness
    Can't tell (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly

Feb 25, 2013 (Started Jul 01, 2010)

  • Effectiveness
    Can't tell (for generalized anxiety disorder)
  • Effectiveness
    Can't tell (for bipolar II disorder)
  • Effectiveness
    Can't tell (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Major (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks

Aug 31, 2016 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly
Side effects: fuzzy thinking

Jul 29, 2011 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly
Side effects: fuzzy thinking

Jan 26, 2010 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    Mild (fuzzy thinking)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Decided that the fuzzy head feeling from it might not be worth the benefit. I will go off for a few weeks and see if it was making a big emough difference in my pain in hands to warrant going back on.
Cost: $50-99 monthly
Side effects: fuzzy thinking

Jan 12, 2010 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    Mild (fuzzy thinking)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am weaning off this drug as it doesn't seem to be helping alot
Cost: $50-99 monthly
Side effects: fuzzy thinking

Dec 4, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $50-99 monthly
Side effects: fuzzy thinking

Oct 29, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly
Side effects: fuzzy thinking

Sep 23, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly
Side effects: fuzzy thinking

  • 0 helpful marks

Jul 6, 2016 (Started Aug 08, 2009)

  • Effectiveness
    Moderate (for fibromyalgia)
  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I didn't think Cymbalta helped my pain, so I weaned off of it.  I couldn't believe how much worse my pain was without Cymbalta, so I went back to taking it daily.  I am not sure that it's the best treatment for my depression though!
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 319 patient evaluations for Duloxetine