What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,199 2,398
Depressed mood 1,849 1,023
Major Depressive Disorder 1,346 785
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 679 354
Generalized Anxiety Disorder 653 464
Pain 500 280

Show all 321 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 760
Moderate 809
Mild 911
None 1,226

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 234
Weight gain 220
Sex drive (libido) decreased 151
Dizziness 138
Dry mouth 124
Sweating increased 96

Show all 655 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 248
30 mg daily 116
120 mg daily 64
90 mg daily 50
60 mg twice daily 33
20 mg daily 32
30 mg twice daily 20
40 mg daily 11
120 mg twice daily 5
20 mg twice daily 3

See all 35 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1555
Did not seem to work 1311
Doctor's advice 504
Expense 409
Other 380
Personal research 146
Change in health plan coverage 141
Course of treatment ended 62
See all 3017 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 8
1 - 6 months 46
6 months - 1 year 40
1 - 2 years 91
2 - 5 years 177
5 - 10 years 196
10 years or more 63

Stopped taking Duloxetine

Duration Patients
Less than 1 month 635
1 - 6 months 901
6 months - 1 year 484
1 - 2 years 430
2 - 5 years 438
5 - 10 years 118
10 years or more 26
Adherence
Adherence Evaluations
Always 3135
Usually 330
Sometimes 55
Never taken as prescribed 186
Burden
Burden Evaluations
Very hard to take 228
Somewhat hard to take 292
A little hard to take 453
Not at all hard to take 2733
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 169
$50-99 386
$25-49 580
< $25 1066
Not specified 1389

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 61
Venlafaxine (Effexor XR) 56
Fluoxetine (Prozac) 52
Escitalopram (Lexapro) 47
Sertraline (Zoloft) 46

Show all 53 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 42
Pregabalin (Lyrica) 30
Bupropion (Wellbutrin XL) 23
Sertraline (Zoloft) 22
Gabapentin (Neurontin) 21

Show all 51 treatments patients report switching to

Last updated:

317 patient evaluations for Duloxetine

2,940 members have decided to share their profiles only with other members of PatientsLikeMe.

pattimarie
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pattimarie
Gender: F
Data Quality: 1 star
Pain: Most
Fatigue: All
Sleep: All
Stiffness: All
function: Some
external_stress: Most
Stickman: all
Description:F57y
FM:24y Dx
CFS:21y Dx
I am: b
I have:
Fibromyalgia

See pattimarie's full Duloxetine history

Jul 6, 2016 (Started Aug 08, 2009)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Slight (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I didn't think Cymbalta helped my pain, so I weaned off of it.  I couldn't believe how much worse my pain was without Cymbalta, so I went back to taking it daily.  I am not sure that it's the best treatment for my depression though!
Cost: $25-49 monthly

  • 0 helpful marks
freka
49727 thumb
freka
Data Quality: 3 stars
  • Gender: F
  • Age: 41
Condition: POTS 3 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Moderate
I am: b
I have:
POTS

See freka's full Duloxetine history

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Severe (Brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for Pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can’t tell (for Pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
rainydaygirl
64355 thumb
rainydaygirl
Gender: F
Data Quality: 3 stars
Pain: Some
Fatigue: All
Sleep: All
Stiffness: Most
function: None
external_stress: Little
Stickman: most
Description:F73y
FM:27y Dx
CFS:8y Dx
I am: n
I have:
Fibromyalgia

See rainydaygirl's full Duloxetine history

May 29, 2016 (Started Jul 15, 2002)

  • Effectiveness
    Can’t tell (for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome)
  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily

Mar 1, 2011 (Started Jul 15, 2002)

  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Slight (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: For depression (which occured years before FMS or CFS), it took me several different depression meds to find out one that helped or didn't cause undesirably side effects. Cymbalta works for me. Don't give up if the firstbtwo or three don't work.

  • 1 helpful mark
Last updated:
Showing 3 of 317 patient evaluations for Duloxetine