What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,792 2,817
Depressed mood 1,935 1,089
Major Depressive Disorder 1,587 958
Generalized Anxiety Disorder 701 493
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 684 368
Pain 517 290

Show all 341 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 844
Moderate 895
Mild 1,038
None 1,501

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 270
Weight gain 259
Dizziness 157
Sex drive (libido) decreased 153
Dry mouth 145
Sweating increased 98

Show all 705 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 471
30 mg daily 185
120 mg daily 108
60 mg twice daily 86
90 mg daily 84
20 mg daily 67
30 mg twice daily 44
40 mg daily 32
120 mg twice daily 23
20 mg twice daily 9

See all 56 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1645
Did not seem to work 1422
Doctor's advice 534
Expense 425
Other 403
Personal research 157
Change in health plan coverage 150
Course of treatment ended 63
See all 3220 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 12
1 - 6 months 97
6 months - 1 year 146
1 - 2 years 208
2 - 5 years 316
5 - 10 years 315
10 years or more 126

Stopped taking Duloxetine

Duration Patients
Less than 1 month 697
1 - 6 months 929
6 months - 1 year 523
1 - 2 years 461
2 - 5 years 470
5 - 10 years 127
10 years or more 29
Adherence
Adherence Evaluations
Always 3600
Usually 373
Sometimes 63
Never taken as prescribed 242
Burden
Burden Evaluations
Very hard to take 264
Somewhat hard to take 331
A little hard to take 504
Not at all hard to take 3179
Cost per month
Cost per month Evaluations
$200+ 118
$100-199 180
$50-99 410
$25-49 638
< $25 1343
Not specified 1589

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 118
Fluoxetine (Prozac) 89
Venlafaxine (Effexor XR) 85
Sertraline (Zoloft) 77
Citalopram (Celexa) 64

Show all 63 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 54
Venlafaxine (Effexor XR) 53
Gabapentin (Neurontin) 34
Sertraline (Zoloft) 29
Bupropion (Wellbutrin XL) 27

Show all 66 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,449 members have decided to share their profiles only with other members of PatientsLikeMe.

pattimarie
86780 thumb
pattimarie
Gender: F
Data Quality: 1 star
Pain: Most
Fatigue: All
Sleep: All
Stiffness: All
function: Some
external_stress: Most
Stickman: all
Description:F58y
FM:25y Dx
CFS:21y Dx
I am: b
I have:
Fibromyalgia

See pattimarie's full Duloxetine history

Jul 6, 2016 (Started Aug 08, 2009)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Slight (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I didn't think Cymbalta helped my pain, so I weaned off of it.  I couldn't believe how much worse my pain was without Cymbalta, so I went back to taking it daily.  I am not sure that it's the best treatment for my depression though!
Cost: $25-49 monthly

  • 0 helpful marks
freka
49727 thumb
freka
Data Quality: 3 stars
  • Gender: F
  • Age: 41
Condition: POTS 3 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Moderate
I am: b
I have:
POTS

See freka's full Duloxetine history

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Severe (Brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for Pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can’t tell (for Pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
rainydaygirl
64355 thumb
rainydaygirl
Gender: F
Data Quality: 3 stars
Pain: Some
Fatigue: All
Sleep: All
Stiffness: Most
function: None
external_stress: Some
Stickman: all
Description:F73y
FM:27y Dx
CFS:8y Dx
I am: n
I have:
Fibromyalgia

See rainydaygirl's full Duloxetine history

May 29, 2016 (Started Jul 15, 2002)

  • Effectiveness
    Can’t tell (for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome)
  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily

Mar 1, 2011 (Started Jul 15, 2002)

  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Slight (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: For depression (which occured years before FMS or CFS), it took me several different depression meds to find out one that helped or didn't cause undesirably side effects. Cymbalta works for me. Don't give up if the firstbtwo or three don't work.

  • 1 helpful mark
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine