What is Duloxetine?

Category: Prescription Drugs

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,219 3,127
Depressed mood 2,034 1,180
Major depressive disorder 1,837 1,116
Generalized anxiety disorder 782 547
Myalgic encephalomyelitis/chronic fatigue syndrome 696 385
Pain 525 306

Show all 315 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 910
Moderate 991
Mild 1,121
None 1,693

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 308
Nausea 283
Dry mouth 162
Dizziness 155
Decreased sex drive (libido) 151
Sweating increased 100

Show all 745 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 410
30 mg daily 142
120 mg daily 119
90 mg daily 79
60 mg twice daily 77
20 mg daily 65
30 mg twice daily 36
40 mg daily 25
20 mg twice daily 16
120 mg twice daily 16

See all 44 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1716
Did not seem to work 1504
Doctor's advice 570
Expense 444
Other 422
Personal research 168
Change in health plan coverage 158
Course of treatment ended 68
See all 3402 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 3
1 - 6 months 85
6 months - 1 year 77
1 - 2 years 165
2 - 5 years 318
5 - 10 years 311
10 years or more 121

Stopped taking Duloxetine

Duration Patients
Less than 1 month 741
1 - 6 months 956
6 months - 1 year 555
1 - 2 years 484
2 - 5 years 504
5 - 10 years 146
10 years or more 33
Adherence
Adherence Evaluations
Always 3953
Usually 416
Sometimes 70
Never taken as prescribed 276
Burden
Burden Evaluations
Very hard to take 295
Somewhat hard to take 362
A little hard to take 547
Not at all hard to take 3511
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 190
$50-99 428
$25-49 679
< $25 1523
Not specified 1769

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 152
Fluoxetine (Prozac) 122
Venlafaxine (Effexor XR) 116
Sertraline (Zoloft) 101
Citalopram (Celexa) 91

Show all 72 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 76
Venlafaxine (Effexor XR) 64
Gabapentin (Neurontin) 54
Sertraline (Zoloft) 35
Bupropion (Wellbutrin XL) 34

Show all 74 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Mar 1, 2017 (Started Oct 30, 2013)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (insomnia, headaches, bitter taste, daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Jul 10, 2016 (Started Oct 30, 2013)

  • Effectiveness
    Can’t tell (for fibromyalgia)
  • Effectiveness
    Can’t tell (for depressed mood)
  • Side effects
    Moderate (insomnia, headaches, bitter taste, daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Cost: < $25 monthly

Jul 7, 2016 (Started Oct 30, 2013)

  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Can’t tell (for depressed mood)
  • Side effects
    Mild (insomnia, headaches, bitter taste, daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Cost: < $25 monthly

Jul 3, 2016 (Started Oct 30, 2013)

  • Effectiveness
    Can’t tell (for fibromyalgia)
  • Effectiveness
    Can’t tell (for depressed mood)
  • Side effects
    Mild (daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Cost: < $25 monthly

Nov 2, 2013 (Started Oct 30, 2013)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Severe (daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: $50-99 monthly

Oct 30, 2013 (Started Oct 30, 2013)

  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Can’t tell (for depressed mood)
  • Side effects
    Mild (daytime sleepiness, constipation, migraine headaches, gas pain, nausea)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 30 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    Mild (seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    Mild (seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine