What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,981 2,977
Depressed mood 1,969 1,123
Major Depressive Disorder 1,709 1,039
Generalized Anxiety Disorder 733 518
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 688 371
Pain 519 294

Show all 351 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 882
Moderate 944
Mild 1,092
None 1,593

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 288
Nausea 279
Dizziness 158
Dry mouth 156
Sex drive (libido) decreased 155
Sweating increased 99

Show all 723 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 547
30 mg daily 224
120 mg daily 133
60 mg twice daily 104
90 mg daily 101
20 mg daily 79
30 mg twice daily 53
40 mg daily 42
120 mg twice daily 25
20 mg twice daily 13

See all 58 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1673
Did not seem to work 1456
Doctor's advice 542
Expense 431
Other 410
Personal research 164
Change in health plan coverage 153
Course of treatment ended 63
See all 3294 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 8
1 - 6 months 106
6 months - 1 year 212
1 - 2 years 254
2 - 5 years 381
5 - 10 years 356
10 years or more 146

Stopped taking Duloxetine

Duration Patients
Less than 1 month 714
1 - 6 months 937
6 months - 1 year 538
1 - 2 years 471
2 - 5 years 485
5 - 10 years 133
10 years or more 32
Adherence
Adherence Evaluations
Always 3791
Usually 396
Sometimes 64
Never taken as prescribed 260
Burden
Burden Evaluations
Very hard to take 279
Somewhat hard to take 348
A little hard to take 529
Not at all hard to take 3355
Cost per month
Cost per month Evaluations
$200+ 122
$100-199 187
$50-99 420
$25-49 659
< $25 1433
Not specified 1690

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 129
Fluoxetine (Prozac) 103
Venlafaxine (Effexor XR) 98
Sertraline (Zoloft) 84
Citalopram (Celexa) 78

Show all 69 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 64
Venlafaxine (Effexor XR) 57
Gabapentin (Neurontin) 42
Bupropion (Wellbutrin XL) 32
Sertraline (Zoloft) 31

Show all 69 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,655 members have decided to share their profiles only with other members of PatientsLikeMe.

pattimarie
86780 thumb
pattimarie
Gender: F
Data Quality: 1 star
Pain: Most
Fatigue: All
Sleep: All
Stiffness: All
function: Some
external_stress: Most
Stickman: all
Description:F58y
FM:25y Dx
CFS:22y Dx
I am: b
I have:
Fibromyalgia

See pattimarie's full Duloxetine history

Jul 6, 2016 (Started Aug 08, 2009)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Slight (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I didn't think Cymbalta helped my pain, so I weaned off of it.  I couldn't believe how much worse my pain was without Cymbalta, so I went back to taking it daily.  I am not sure that it's the best treatment for my depression though!
Cost: $25-49 monthly

  • 0 helpful marks
freka
49727 thumb
freka
Data Quality: 3 stars
  • Gender: F
  • Age: 41
Condition: POTS 3 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Moderate
I am: b
I have:
POTS

See freka's full Duloxetine history

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Severe (Brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for Pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can’t tell (for Pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
rainydaygirl
64355 thumb
rainydaygirl
Gender: F
Data Quality: 3 stars
Pain: Some
Fatigue: All
Sleep: All
Stiffness: Most
function: None
external_stress: Little
Stickman: most
Description:F73y
FM:27y Dx
CFS:8y Dx
I am: n
I have:
Fibromyalgia

See rainydaygirl's full Duloxetine history

May 29, 2016 (Started Jul 15, 2002)

  • Effectiveness
    Can’t tell (for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome)
  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily

Mar 1, 2011 (Started Jul 15, 2002)

  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Slight (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: For depression (which occured years before FMS or CFS), it took me several different depression meds to find out one that helped or didn't cause undesirably side effects. Cymbalta works for me. Don't give up if the firstbtwo or three don't work.

  • 1 helpful mark
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine