What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
fibromyalgia 6,084 3,059
Depressed mood 1,996 1,148
major depressive disorder 1,758 1,073
generalized anxiety disorder 756 534
myalgic encephalomyelitis/chronic fatigue syndrome 693 378
Pain 521 299

Show all 353 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 897
Moderate 972
Mild 1,106
None 1,639

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 297
Nausea 285
Dizziness 159
Dry mouth 159
Sex drive (libido) decreased 157
Sweating increased 100

Show all 728 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 522
30 mg daily 208
120 mg daily 129
90 mg daily 100
60 mg twice daily 91
20 mg daily 86
30 mg twice daily 56
40 mg daily 34
120 mg twice daily 25
20 mg twice daily 15

See all 56 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1694
Did not seem to work 1482
Doctor's advice 558
Expense 436
Other 417
Personal research 167
Change in health plan coverage 154
Course of treatment ended 67
See all 3347 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 21
1 - 6 months 87
6 months - 1 year 116
1 - 2 years 217
2 - 5 years 427
5 - 10 years 367
10 years or more 172

Stopped taking Duloxetine

Duration Patients
Less than 1 month 726
1 - 6 months 951
6 months - 1 year 548
1 - 2 years 475
2 - 5 years 494
5 - 10 years 137
10 years or more 32
Adherence
Adherence Evaluations
Always 3865
Usually 408
Sometimes 68
Never taken as prescribed 273
Burden
Burden Evaluations
Very hard to take 293
Somewhat hard to take 358
A little hard to take 540
Not at all hard to take 3423
Cost per month
Cost per month Evaluations
$200+ 124
$100-199 187
$50-99 426
$25-49 671
< $25 1474
Not specified 1732

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 142
Fluoxetine (Prozac) 109
Venlafaxine (Effexor XR) 104
Sertraline (Zoloft) 89
Citalopram (Celexa) 82

Show all 71 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 72
Venlafaxine (Effexor XR) 57
Gabapentin (Neurontin) 51
Sertraline (Zoloft) 33
Bupropion (Wellbutrin XL) 32

Show all 70 treatments patients report switching to

Last updated:

317 patient evaluations for Duloxetine

Oct 22, 2016 (Started Oct 15, 2011)

  • Effectiveness
    Moderate (for Pain)
  • Effectiveness
    Moderate (for fibromyalgia)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 60 mg Twice daily
Advice & Tips: If you are hesitant to take any antidepressant because of weight gain or sexual desire issues, try it first.  If it does cause that, you can always be switched to another antidepressant.  There are many, many of these different formulae available to you and your doctor and it might take a while to find the one that is right for you.  Also, internal med MDs and GPs often don't give high enough dosages to be clinically significant (studies show), so if your depression and pain aren't improving, consider a one-time or a short course of visits to a psychiatrist, because they are experts in prescriptions for mental health issues.
Cost: < $25 monthly

  • 0 helpful marks

Oct 15, 2016 (Started Jul 01, 2010)

  • Effectiveness
    Can’t tell (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Can’t tell (for generalized anxiety disorder)
  • Effectiveness
    Can’t tell (for fibromyalgia)
  • Effectiveness
    Can’t tell (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly

Feb 25, 2013 (Started Jul 01, 2010)

  • Effectiveness
    Can’t tell (for generalized anxiety disorder)
  • Effectiveness
    Can’t tell (for bipolar II disorder)
  • Effectiveness
    Can’t tell (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Major (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks

Aug 31, 2016 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for Peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly
Side effects: Fuzzy thinking

Jul 29, 2011 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for Peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: $50-99 monthly
Side effects: Fuzzy thinking

Jan 26, 2010 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for Peripheral neuritis)
  • Side effects
    Mild (Fuzzy thinking)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Decided that the fuzzy head feeling from it might not be worth the benefit. I will go off for a few weeks and see if it was making a big emough difference in my pain in hands to warrant going back on.
Cost: $50-99 monthly
Side effects: Fuzzy thinking

Jan 12, 2010 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for Peripheral neuritis)
  • Side effects
    Mild (Fuzzy thinking)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am weaning off this drug as it doesn't seem to be helping alot
Cost: $50-99 monthly
Side effects: Fuzzy thinking

Dec 4, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for Peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $50-99 monthly
Side effects: Fuzzy thinking

Oct 29, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Moderate (for Peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly
Side effects: Fuzzy thinking

Sep 23, 2009 (Started Jun 05, 2009)

  • Effectiveness
    Slight (for Peripheral neuritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly
Side effects: Fuzzy thinking

  • 0 helpful marks
Last updated:
Showing 3 of 317 patient evaluations for Duloxetine