What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,587 2,676
Depressed mood 1,902 1,066
Major Depressive Disorder 1,491 892
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 681 363
Generalized Anxiety Disorder 674 482
Pain 510 287

Show all 336 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 819
Moderate 865
Mild 997
None 1,407

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 253
Weight gain 246
Dizziness 153
Sex drive (libido) decreased 152
Dry mouth 140
Sweating increased 98

Show all 688 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 390
30 mg daily 166
120 mg daily 88
90 mg daily 72
60 mg twice daily 70
20 mg daily 51
30 mg twice daily 37
40 mg daily 23
120 mg twice daily 16
20 mg twice daily 6

See all 46 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1620
Did not seem to work 1382
Doctor's advice 521
Expense 420
Other 388
Personal research 149
Change in health plan coverage 148
Course of treatment ended 63
See all 3146 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 7
1 - 6 months 75
6 months - 1 year 120
1 - 2 years 167
2 - 5 years 254
5 - 10 years 267
10 years or more 112

Stopped taking Duloxetine

Duration Patients
Less than 1 month 681
1 - 6 months 917
6 months - 1 year 512
1 - 2 years 448
2 - 5 years 454
5 - 10 years 123
10 years or more 27
Adherence
Adherence Evaluations
Always 3442
Usually 361
Sometimes 60
Never taken as prescribed 225
Burden
Burden Evaluations
Very hard to take 255
Somewhat hard to take 319
A little hard to take 492
Not at all hard to take 3022
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 174
$50-99 401
$25-49 615
< $25 1254
Not specified 1528

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 104
Fluoxetine (Prozac) 80
Venlafaxine (Effexor XR) 75
Sertraline (Zoloft) 67
Citalopram (Celexa) 58

Show all 59 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 47
Pregabalin (Lyrica) 45
Gabapentin (Neurontin) 30
Bupropion (Wellbutrin XL) 27
Sertraline (Zoloft) 25

Show all 62 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,284 members have decided to share their profiles only with other members of PatientsLikeMe.

pattimarie
86780 thumb
pattimarie
Gender: F
Data Quality: 1 star
Pain: Most
Fatigue: All
Sleep: All
Stiffness: All
function: Some
external_stress: Most
Stickman: all
Description:F58y
FM:24y Dx
CFS:21y Dx
I am: b
I have:
Fibromyalgia

See pattimarie's full Duloxetine history

Jul 6, 2016 (Started Aug 08, 2009)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Slight (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I didn't think Cymbalta helped my pain, so I weaned off of it.  I couldn't believe how much worse my pain was without Cymbalta, so I went back to taking it daily.  I am not sure that it's the best treatment for my depression though!
Cost: $25-49 monthly

  • 0 helpful marks
freka
49727 thumb
freka
Data Quality: 3 stars
  • Gender: F
  • Age: 41
Condition: POTS 3 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Moderate
I am: b
I have:
POTS

See freka's full Duloxetine history

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Severe (Brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for Pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can’t tell (for Pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
rainydaygirl
64355 thumb
rainydaygirl
Gender: F
Data Quality: 3 stars
Pain: Most
Fatigue: All
Sleep: All
Stiffness: Little
function: None
external_stress: Little
Stickman: most
Description:F73y
FM:27y Dx
CFS:8y Dx
I am: n
I have:
Fibromyalgia

See rainydaygirl's full Duloxetine history

May 29, 2016 (Started Jul 15, 2002)

  • Effectiveness
    Can’t tell (for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome)
  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily

Mar 1, 2011 (Started Jul 15, 2002)

  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Slight (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: For depression (which occured years before FMS or CFS), it took me several different depression meds to find out one that helped or didn't cause undesirably side effects. Cymbalta works for me. Don't give up if the firstbtwo or three don't work.

  • 1 helpful mark
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine