What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,890 1,916
Stiffness/spasticity 111 84
Multiple system atrophy 86 57
Restless legs syndrome 81 64
Tremor(s) 62 58
Slow movement (bradykinesia) 53 36

Show all 87 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 91
Moderate 398
Mild 625
None 924

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements 163
Nausea 143
Drowsiness 48
Constipation 31
Headaches 26
Fatigue 21

Show all 279 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 91
25-100 mg four times daily 36
3 x 25 mg-100 mg daily 31
2 x 25-100 mg three times daily 29
25 mg-100 mg three times daily 28
25-100 mg five times daily 27
4 x 25 mg-100 mg daily 22
25 mg-100 mg daily 20
2 x 25-100 mg four times daily 18
1.5 x 25-100 mg three times daily 16

See all 209 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 141
Did not seem to work 112
Side effects too severe 98
Other 75
Personal research 32
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 386 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 2
1 - 6 months 22
6 months - 1 year 36
1 - 2 years 86
2 - 5 years 224
5 - 10 years 265
10 years or more 115

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 49
1 - 6 months 89
6 months - 1 year 56
1 - 2 years 64
2 - 5 years 95
5 - 10 years 42
10 years or more 9
Adherence
Adherence Evaluations
Always 1489
Usually 433
Sometimes 50
Never taken as prescribed 66
Burden
Burden Evaluations
Very hard to take 63
Somewhat hard to take 312
A little hard to take 512
Not at all hard to take 1151
Cost per month
Cost per month Evaluations
$200+ 20
$100-199 24
$50-99 69
$25-49 177
< $25 1137
Not specified 611

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 48
Pramipexole (Mirapex) 41
Rasagiline (Azilect) 26
Amantadine (Symmetrel) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 19

Show all 19 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 69
Ropinirole (Requip) 16
Carbidopa-Entacapone-Levodopa (Stalevo) 15
Carbidopa-Levodopa CR (Sinemet CR) 11
Pramipexole (Mirapex) 11

Show all 20 treatments patients report switching to

Last updated:

133 patient evaluations for Carbidopa-Levodopa

Aug 15, 2018 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25-100 mg Five times daily
Advice & Tips: On advice of my MDS I switched to Rytary to even out the on/off periods I took c/l 25/100 for 13 years and did well on it
Cost: < $25 monthly

Nov 4, 2015 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 tablet(s) Four times daily

May 31, 2015 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 tablet(s) Four times daily

  • 1 helpful mark

Jul 15, 2018 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Mar 22, 2017 (Started Aug 18, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 9, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Jun 16, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 22, 2015 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Nov 21, 2013 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 6, 2012 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 5, 2011 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

May 22, 2018 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: all the same
Cost: < $25 monthly
Side effects: jerky movements

Dec 21, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

May 1, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: suddenly became more dyskinetic and realized it was important to cut back on amount
Cost: < $25 monthly
Side effects: jerky movements

Feb 18, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Jan 17, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Aug 19, 2008 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Other)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    A little hard to take
Dosage: 800 mg Daily
Advice & Tips: use exactly as directed to avoid side effects
Cost: < $25 monthly
Side effects: jerky movements

  • 1 helpful mark
Last updated:
Showing 3 of 133 patient evaluations for Carbidopa-Levodopa