What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,908 1,919
Stiffness/spasticity 111 84
Multiple system atrophy 87 59
Restless legs syndrome 81 64
Tremor(s) 62 58
Slow movement (bradykinesia) 53 36

Show all 88 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 91
Moderate 398
Mild 625
None 927

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements 163
Nausea 143
Drowsiness 48
Constipation 32
Headaches 26
Fatigue 21

Show all 276 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 86
25-100 mg four times daily 40
2 x 25-100 mg three times daily 32
3 x 25 mg-100 mg daily 31
25-100 mg five times daily 27
25 mg-100 mg three times daily 25
4 x 25 mg-100 mg daily 20
25 mg-100 mg daily 19
2 x 25-100 mg four times daily 17
25-100 mg twice daily 14

See all 199 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 140
Did not seem to work 111
Side effects too severe 97
Other 76
Personal research 31
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 385 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 1
1 - 6 months 30
6 months - 1 year 37
1 - 2 years 82
2 - 5 years 212
5 - 10 years 248
10 years or more 104

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 49
1 - 6 months 88
6 months - 1 year 55
1 - 2 years 64
2 - 5 years 95
5 - 10 years 42
10 years or more 9
Adherence
Adherence Evaluations
Always 1494
Usually 433
Sometimes 49
Never taken as prescribed 65
Burden
Burden Evaluations
Very hard to take 63
Somewhat hard to take 311
A little hard to take 515
Not at all hard to take 1152
Cost per month
Cost per month Evaluations
$200+ 21
$100-199 24
$50-99 69
$25-49 177
< $25 1136
Not specified 614

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 48
Pramipexole (Mirapex) 42
Rasagiline (Azilect) 26
Amantadine (Symmetrel) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 20

Show all 19 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 69
Carbidopa-Entacapone-Levodopa (Stalevo) 16
Ropinirole (Requip) 16
Carbidopa-Levodopa CR (Sinemet CR) 11
Pramipexole (Mirapex) 11

Show all 20 treatments patients report switching to

Last updated:

133 patient evaluations for Carbidopa-Levodopa

Dec 30, 2009 (Started )

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    A little hard to take
Advice & Tips: When taken alone, one dose lasts about an hour or so. When taken with Comtan, "ON" period is extended up to 2 - 2.5 hours. Needs to be taken on empty stomach. Proteins, fats, or a full stomach (even a moderately full feeling) disrupts effectiveness. Rate if absorption is decreased with presence of food in stomach or "ON" period is prevented altogether. Usually takes 40-50 minutes for a dose to kick in. Can be speeded up by disolving tablet in water first or by taking with a cola beverage. Unexpected benefits are when I am "ON", others have a hard time keeping up with me.

  • 7 helpful marks

Jun 16, 2006 (Started Jun 09, 2006)

  • Effectiveness
    Major (for Other)
  • Side effects
    Severe (whole body pain, skin rash, nausea, emotional lability)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 10 mg-100 mg Daily
Side effects: whole body pain, emotional lability, skin rash, nausea, nausea

  • 2 helpful marks

Mar 16, 2010 (Started Jul 06, 2004)

  • Effectiveness
    Major (for tremor in hands)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: This drug, along with Mirapex, has controlled the tremor in my hands....get a bit of tremor rarely when really cold or on down times of meds. Dr. just changed me to extended release med due to some "twitching" i have been getting which he thinks may be related to too much of med. I was taking 2 (25/100) pills 4x daily. Now with extended release, which is 50/200, i will take 1 3x day. Will see if this helps.
Cost: < $25 monthly

Jun 7, 2009 (Started Jul 06, 2004)

  • Effectiveness
    Major (for tremor in hands)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: taking generic of sinemet and using insurance is much less costly. this med was increased about 6 mos. ago due to slight increase in tremor and start of tremor in other hand. This med along with Mirapex controls my tremors .... off times are early mornings when first arising.
Cost: < $25 monthly

  • 2 helpful marks
Last updated:
Showing 3 of 133 patient evaluations for Carbidopa-Levodopa