What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,587 2,676
Depressed mood 1,902 1,066
Major Depressive Disorder 1,491 892
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 681 363
Generalized Anxiety Disorder 674 482
Pain 510 287

Show all 336 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 819
Moderate 865
Mild 997
None 1,407

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 253
Weight gain 246
Dizziness 153
Sex drive (libido) decreased 152
Dry mouth 140
Sweating increased 98

Show all 688 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 390
30 mg daily 166
120 mg daily 88
90 mg daily 72
60 mg twice daily 70
20 mg daily 51
30 mg twice daily 37
40 mg daily 23
120 mg twice daily 16
20 mg twice daily 6

See all 46 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1620
Did not seem to work 1382
Doctor's advice 521
Expense 420
Other 388
Personal research 149
Change in health plan coverage 148
Course of treatment ended 63
See all 3146 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 7
1 - 6 months 75
6 months - 1 year 120
1 - 2 years 167
2 - 5 years 254
5 - 10 years 267
10 years or more 112

Stopped taking Duloxetine

Duration Patients
Less than 1 month 681
1 - 6 months 917
6 months - 1 year 512
1 - 2 years 448
2 - 5 years 454
5 - 10 years 123
10 years or more 27
Adherence
Adherence Evaluations
Always 3442
Usually 361
Sometimes 60
Never taken as prescribed 225
Burden
Burden Evaluations
Very hard to take 255
Somewhat hard to take 319
A little hard to take 492
Not at all hard to take 3022
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 174
$50-99 401
$25-49 615
< $25 1254
Not specified 1528

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 104
Fluoxetine (Prozac) 80
Venlafaxine (Effexor XR) 75
Sertraline (Zoloft) 67
Citalopram (Celexa) 58

Show all 59 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 47
Pregabalin (Lyrica) 45
Gabapentin (Neurontin) 30
Bupropion (Wellbutrin XL) 27
Sertraline (Zoloft) 25

Show all 62 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,283 members have decided to share their profiles only with other members of PatientsLikeMe.

Chrismh1
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Chrismh1
Gender: M
Data Quality: 2 stars
Depression: 3
Mania: 1
Emotional: 1
Anxiety: 2
Compulsion: 3
External Stress: Low
45 M
Function: Moderate
Distress: Moderate
I am: b
I have:
Bipolar I

See Chrismh1's full Duloxetine history

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
a-non-mouse
17881 thumb
a-non-mouse
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: severe
I am: g
I have:
MS

See a-non-mouse's full Duloxetine history

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for Nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
ljpwrites
43698 thumb
ljpwrites
Data Quality: 1 star
  • Gender: F
  • Age: 63
Condition: CNS Lupus 10 additional condition(s)
Quality of life:
  • Mental: Moderate
  • Physical: Mild
I am: g
I have:
CNS Lupus

See ljpwrites's full Duloxetine history

Oct 22, 2016 (Started Oct 15, 2011)

  • Effectiveness
    Moderate (for Pain)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 60 mg Twice daily
Advice & Tips: If you are hesitant to take any antidepressant because of weight gain or sexual desire issues, try it first.  If it does cause that, you can always be switched to another antidepressant.  There are many, many of these different formulae available to you and your doctor and it might take a while to find the one that is right for you.  Also, internal med MDs and GPs often don't give high enough dosages to be clinically significant (studies show), so if your depression and pain aren't improving, consider a one-time or a short course of visits to a psychiatrist, because they are experts in prescriptions for mental health issues.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine