What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

false

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,198 2,398
Depressed mood 1,849 1,023
Major Depressive Disorder 1,346 785
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 679 354
Generalized Anxiety Disorder 653 464
Pain 500 280

Show all 321 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 760
Moderate 809
Mild 911
None 1,226

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 234
Weight gain 220
Sex drive (libido) decreased 151
Dizziness 138
Dry mouth 124
Sweating increased 96

Show all 655 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 257
30 mg daily 111
120 mg daily 64
90 mg daily 50
60 mg twice daily 31
20 mg daily 29
30 mg twice daily 20
40 mg daily 11
20 mg twice daily 5
120 mg twice daily 5

See all 36 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1555
Did not seem to work 1311
Doctor's advice 504
Expense 409
Other 380
Personal research 146
Change in health plan coverage 141
Course of treatment ended 62
See all 3017 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 8
1 - 6 months 46
6 months - 1 year 40
1 - 2 years 90
2 - 5 years 177
5 - 10 years 198
10 years or more 63

Stopped taking Duloxetine

Duration Patients
Less than 1 month 635
1 - 6 months 901
6 months - 1 year 484
1 - 2 years 430
2 - 5 years 438
5 - 10 years 118
10 years or more 26
Adherence
Adherence Evaluations
Always 3135
Usually 330
Sometimes 55
Never taken as prescribed 186
Burden
Burden Evaluations
Very hard to take 228
Somewhat hard to take 292
A little hard to take 453
Not at all hard to take 2733
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 169
$50-99 386
$25-49 580
< $25 1066
Not specified 1389

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 61
Venlafaxine (Effexor XR) 56
Fluoxetine (Prozac) 52
Escitalopram (Lexapro) 47
Sertraline (Zoloft) 46

Show all 53 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 42
Pregabalin (Lyrica) 30
Bupropion (Wellbutrin XL) 23
Sertraline (Zoloft) 22
Gabapentin (Neurontin) 21

Show all 51 treatments patients report switching to

Last updated:

317 patient evaluations for Duloxetine

2,940 members have decided to share their profiles only with other members of PatientsLikeMe.

Chrismh1
24064 thumb
Chrismh1
Gender: M
Data Quality: 3 stars
Depression: 3
Mania: 1
Emotional: 1
Anxiety: 3
Compulsion: 3
External Stress: Severe
44 M
Function: High
Distress: Moderate
I am: g
I have:
Bipolar I

See Chrismh1's full Duloxetine history

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
a-non-mouse
17881 thumb
a-non-mouse
Sex: M
Data Quality: 3 stars
Sensation: Moderate
Overall: Mild
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: severe
I am: g
I have:
MS

See a-non-mouse's full Duloxetine history

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for Nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
ljpwrites
43698 thumb
ljpwrites
Data Quality: 1 star
  • Gender: F
  • Age: 63
Condition: CNS Lupus 10 additional condition(s)
Quality of life:
  • Mental: Moderate
  • Physical: Mild
I am: g
I have:
CNS Lupus

See ljpwrites's full Duloxetine history

Oct 22, 2016 (Started Oct 15, 2011)

  • Effectiveness
    Moderate (for Pain)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 60 mg Twice daily
Advice & Tips: If you are hesitant to take any antidepressant because of weight gain or sexual desire issues, try it first.  If it does cause that, you can always be switched to another antidepressant.  There are many, many of these different formulae available to you and your doctor and it might take a while to find the one that is right for you.  Also, internal med MDs and GPs often don't give high enough dosages to be clinically significant (studies show), so if your depression and pain aren't improving, consider a one-time or a short course of visits to a psychiatrist, because they are experts in prescriptions for mental health issues.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 317 patient evaluations for Duloxetine