What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

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See also: Methotrexate-Vinblastine-Doxorubicin-Cisplatin (MVAC)

Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 1,591 637
Systemic lupus erythematosus 319 141
Psoriatic arthritis 210 102
Psoriasis 185 84
Multiple sclerosis 72 39

Show all 121 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 234
Moderate 311
Mild 264
None 261

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients
Nausea 258
Fatigue 124
Hair loss 94
Headaches 56
Mouth sores (ulcers) 43
Diarrhea 32

Show all 237 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients
20 mg weekly 64
15 mg weekly 55
10 mg weekly 40
25 mg weekly 38
12.5 mg weekly 23
7.5 mg weekly 22
17.5 mg weekly 10
30 mg weekly 10
2.5 mg weekly 5
5 mg weekly 5

See all 58 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients
Side effects too severe 484
Did not seem to work 251
Doctor's advice 243
Other 112
Course of treatment ended 51
Personal research 28
Change in health plan coverage 14
Expense 14
See all 836 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients
Less than 1 month 3
1 - 6 months 33
6 months - 1 year 24
1 - 2 years 36
2 - 5 years 87
5 - 10 years 101
10 years or more 65

Stopped taking Methotrexate

Duration Patients
Less than 1 month 131
1 - 6 months 180
6 months - 1 year 158
1 - 2 years 118
2 - 5 years 153
5 - 10 years 60
10 years or more 34
Adherence
Adherence Evaluations
Always 890
Usually 108
Sometimes 17
Never taken as prescribed 55
Burden
Burden Evaluations
Very hard to take 82
Somewhat hard to take 150
A little hard to take 185
Not at all hard to take 653
Cost per month
Cost per month Evaluations
$200+ 8
$100-199 6
$50-99 24
$25-49 48
< $25 512
Not specified 472

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients
Hydroxychloroquine (Plaquenil) 62
Prednisone (Deltasone) 29
Sulfasalazine (Salazopyrin) 15
Azathioprine (Imuran) 13
Leflunomide (Arava) 9

Show all 45 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients
Leflunomide (Arava) 38
Azathioprine (Imuran) 21
Etanercept (Enbrel SureClick) 21
Adalimumab (Humira) 18
Sulfasalazine (Salazopyrin) 18

Show all 36 treatments patients report switching to

Last updated:

47 patient evaluations for Methotrexate

May 12, 2018 (Started Feb 03, 2010)

  • Effectiveness
    Can't tell (for chronic inflammatory demyelinating polyneuropathy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Slight (for psoriatic arthritis)
  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Mild (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Major (for rheumatoid arthritis)
  • Effectiveness
    Moderate (for Crohn's disease)
  • Side effects
    Moderate (grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 47 patient evaluations for Methotrexate