What is Amitriptyline?

Category: Prescription Drugs

Most popular types: Elavil Endep Trepiline Show all

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See also: Amantadine-amitriptyline-baclofen-clonidine-lidocaine-nifedipine-prilocaine

Amitriptyline is a tricyclic antidepressant used for the treatment of depression. It may also be used for certain chronic and neuropathic (nerve) pain and for prevention of migraine headaches.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 1,074 729
Fibromyalgia 987 624
Pain 931 608
Depressed mood 209 123
Migraine headaches 170 114

Show all 298 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 284
Moderate 416
Mild 556
None 704

Commonly reported side effects and conditions associated with Amitriptyline

Side effect Patients
Dry mouth 184
Weight gain 124
Drowsiness 90
Sleepiness 58
Excessive daytime sleepiness (somnolence) 50
Grogginess 46

Show all 263 reported side effects

Dosages

Based on patients currently taking Amitriptyline

Dosage Patients
25 mg daily 84
50 mg daily 63
10 mg daily 60
20 mg daily 29
100 mg daily 25
30 mg daily 21
75 mg daily 17
150 mg daily 10
200 mg daily 7
25 mg twice daily 5

See all 36 dosages

Why patients stopped taking Amitriptyline

Multiple reasons could be selected

Reason Patients
Did not seem to work 489
Side effects too severe 479
Doctor's advice 273
Other 177
Course of treatment ended 57
Personal research 56
Expense 15
Change in health plan coverage 11
See all 1148 patients who've stopped taking Amitriptyline

Duration

Currently taking Amitriptyline

Duration Patients
1 - 6 months 14
6 months - 1 year 22
1 - 2 years 29
2 - 5 years 111
5 - 10 years 90
10 years or more 86

Stopped taking Amitriptyline

Duration Patients
Less than 1 month 218
1 - 6 months 314
6 months - 1 year 180
1 - 2 years 149
2 - 5 years 190
5 - 10 years 63
10 years or more 39
Adherence
Adherence Evaluations
Always 1560
Usually 243
Sometimes 73
Never taken as prescribed 84
Burden
Burden Evaluations
Very hard to take 89
Somewhat hard to take 122
A little hard to take 247
Not at all hard to take 1502
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 3
$50-99 13
$25-49 40
< $25 1021
Not specified 876

What people switch to and from

Patients started taking Amitriptyline after stopping:

Treatment Patients
Duloxetine (Cymbalta) 16
Gabapentin (Neurontin) 16
Trazodone (Desyrel) 12
Pregabalin (Lyrica) 11
Zolpidem (Ambien) 11

Show all 71 treatments patients report switching from

Patients stopped taking Amitriptyline and switched to:

Treatment Patients
Nortriptyline (Pamelor) 28
Gabapentin (Neurontin) 25
Duloxetine (Cymbalta) 17
Pregabalin (Lyrica) 14
Trazodone (Desyrel) 10

Show all 60 treatments patients report switching to

Last updated:

154 patient evaluations for Amitriptyline

Aug 13, 2018 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Effectiveness
    Major (for increased need for sleep)
  • Side effects
    Moderate (slurred speech, hangover effect, weight gain, fluid retention weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Feeling hung-over in the morning & sudden impact of sleepiness after taken; take. medication right before you have eaten & are ready for bed. Its still the best anti-depressant I've EVER tried!
Cost: < $25 monthly

Dec 15, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (slurred speech, hangover effect, weight gain, fluid retention weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Nov 10, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Mild (slurred speech, hangover effect, weight gain, fluid retention weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Aug 2, 2016 (Started Apr 19, 2012)

  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    Mild (slurred speech, weight gain, fluid retention weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Elavil is becoming unfamiliar with psychiatrists these days; they seem to feel that the old tricylics don't work as well as all the SSRI's that are out there now. Personally, over the vast amount of years with my psychiatrist, we tried everything from A-Z......always came back to Elavil. The SSRI's had terrible side effects & did not work as well. I think it's been quite effective! The weight gain used to be bad until I was dxed w/ Type 2 Diabetes (not on medication/just diet & exercise & glucose monitoring daily) Now I've been losing weight.
Cost: < $25 monthly

  • 0 helpful marks

Jan 27, 2018 (Started Jan 22, 2018)

  • Effectiveness
    Moderate (for pain)
  • Effectiveness
    Major (for insomnia)
  • Effectiveness
    Slight (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Jul 22, 2017 (Started Jul 01, 2002)

  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Slight (for pain)
  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg Daily
Cost: < $25 monthly

Dec 31, 2011 (Started Jul 01, 2002)

  • Effectiveness
    Slight (for insomnia)
  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Slight (for pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Daily
Advice & Tips: This definitely helps with the problems I have sleeping, getting to sleep, staying asleep, getting restorative sleep, depression, and pain. I can tell more when I miss 2 or more nights, usually caused by a refill problem. I try to never run out and have to go without a dose. Missing doses causes all my problems like with sleeping, pain, and depression to become worse and my other medications don't seem as effective. I really take a nose dive if more than 2 doses are missed. Missing only 1 is tolerable, missing anymore becomes a big problem. I get anxious, teary, sleepless, and I feel hopeless. It is a horrible feeling.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 154 patient evaluations for Amitriptyline