What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,831 1,856
Stiffness/spasticity 111 83
Multiple system atrophy 86 58
Restless legs syndrome 79 68
Tremor(s) 60 57
Slow movement (bradykinesia) 53 36

Show all 91 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 86
Moderate 392
Mild 609
None 888

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements 162
Nausea 139
Drowsiness 48
Constipation 32
Upset stomach 26
Headaches 25

Show all 343 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 80
25-100 mg four times daily 42
25 mg-100 mg three times daily 34
3 x 25 mg-100 mg daily 32
25-100 mg five times daily 24
4 x 25 mg-100 mg daily 23
2 x 25-100 mg three times daily 22
25 mg-100 mg daily 21
2 x 25-100 mg four times daily 19
6 x 25 mg-100 mg daily 19

See all 206 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 136
Did not seem to work 111
Side effects too severe 96
Other 75
Personal research 31
Course of treatment ended 20
Change in health plan coverage 7
Expense 5
See all 379 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
1 - 6 months 28
6 months - 1 year 41
1 - 2 years 96
2 - 5 years 238
5 - 10 years 277
10 years or more 105

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 48
1 - 6 months 89
6 months - 1 year 55
1 - 2 years 61
2 - 5 years 94
5 - 10 years 41
10 years or more 9
Adherence
Adherence Evaluations
Always 1448
Usually 420
Sometimes 47
Never taken as prescribed 60
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 309
A little hard to take 492
Not at all hard to take 1113
Cost per month
Cost per month Evaluations
$200+ 18
$100-199 23
$50-99 68
$25-49 171
< $25 1107
Not specified 588

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 47
Pramipexole (Mirapex) 43
Rasagiline (Azilect) 24
Amantadine (Symmetrel) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 19

Show all 18 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 62
Carbidopa-Entacapone-Levodopa (Stalevo) 14
Ropinirole (Requip) 13
Carbidopa-Levodopa CR (Sinemet CR) 10
Pramipexole (Mirapex) 10

Show all 21 treatments patients report switching to

Last updated:

133 patient evaluations for Carbidopa-Levodopa

Apr 11, 2018 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for dystonia)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 x 25-100 mg Five times daily
Cost: < $25 monthly

Nov 4, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for dystonia)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 2 x 25-100 mg Five times daily
Advice & Tips: must eat carbs before taking medicine so I don't get sick to my stomach.
Cost: < $25 monthly

Aug 10, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for dystonia)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 2 x 25-100 mg Five times daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit. I take 2 tablets times 4 times daily of the 25/100 mg. tablets
Cost: < $25 monthly

May 25, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Effectiveness
    Moderate (for dystonia)
  • Side effects
    Moderate (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 2 x 25-100 mg Five times daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit. I take 2 tablets times 4 times daily of the 25/100 mg. tablets
Cost: < $25 monthly

Jan 17, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Moderate (for dystonia)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit.
Cost: < $25 monthly

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Effectiveness
    Slight (for dystonia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Slight (for dystonia)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: crackers help
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Slight (for dystonia)
  • Side effects
    Moderate (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I continue to be nausea, but crackers help.
Cost: < $25 monthly

  • 0 helpful marks

Mar 28, 2018 (Started Mar 15, 2005)

  • Effectiveness
    Slight (for dystonia)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I AM ON RYTARY 48.75MG/195MG NOT XR. THIS MEDICATION IS ONLY SLIGHTLY WORKING. I WAS ON STALEVO 200MG WHICH WORKED GREAT FOR 9 YEARS. THEN IT WORE OFF QUICKLY AND I WAS PUT ON RYTARY.
Cost: $100-199 monthly

  • 1 helpful mark

Aug 15, 2017 (Started Jun 12, 2007)

  • Effectiveness
    Moderate (for walking difficult without aid)
  • Effectiveness
    Moderate (for tremor in hands)
  • Effectiveness
    Moderate (for stiffness/spasticity)
  • Effectiveness
    Moderate (for slow movement (bradykinesia))
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Moderate (for mobility decreased)
  • Effectiveness
    Moderate (for loss of balance)
  • Effectiveness
    Moderate (for balance problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25-100 mg Twice daily
Advice & Tips: I am taking three sinemet per day after Dbs
Cost: < $25 monthly
Side effects: jerky movements, drowsiness

Jan 15, 2017 (Started Jun 12, 2007)

  • Effectiveness
    Major (for walking difficult without aid)
  • Effectiveness
    Major (for tremor in hands)
  • Effectiveness
    Major (for stiffness/spasticity)
  • Effectiveness
    Major (for slow movement (bradykinesia))
  • Effectiveness
    Major (for Parkinson's disease)
  • Effectiveness
    Major (for mobility decreased)
  • Effectiveness
    Moderate (for loss of balance)
  • Effectiveness
    Moderate (for balance problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25-100 mg Twice daily
Advice & Tips: As of January 2017 I have stopped taking sinemet because I had DBS.
Cost: < $25 monthly
Side effects: jerky movements, drowsiness

May 11, 2014 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements, drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: As of today, I am still taking six sinemet daily, two pills at a time. Even when I am off, I can write and type almost as well as ever. And even when off, I have no tremor (unless I try to walk, then my right hand shakes.) And when I am on, my walking is generally normal. (I sometimes have problems with freezing when on.) My balance is also much better when I'm on. When off, I have difficulty standing on one leg, but I can do so for a minute or more when on.
Cost: < $25 monthly
Side effects: jerky movements, drowsiness

Sep 19, 2010 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements, drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: At my most recent neurologist visit, she told me I had dyskinesias. My wife has also noticed them. I'm not sure how long I"ve had them, probably a few months. At my previous visit, three months ago (when I saw the Nurse Practitioner, not the neurologist), the Nurse did not mention them. They are quite mild - at least mild enough that I don't notice. My neurologist has suggested I take more Amantadine to see if this reduces them.
Cost: < $25 monthly
Side effects: jerky movements, drowsiness

Mar 29, 2009 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: The first neurologist I saw, in March 2006, had me try a couple of sinemet per day. They had absolutely no effect. The second neurologist I saw, in April 2007, had me take a half tablet per day for the first week, one tablet daily the second, one and a half daily the third, and so on until I was taking four daily after eight weeks. It had no effect until the fifth week, when I started taking two and a half tablets daily. At that time, it improved my eating, dressing, and showering, but did not improve my writing or typing or walking. Later in 2007 I went to five sinemet daily, with little change. During the summer of 2008 I went to six, and my writing and typing essentially became normal. Even when off I’m able to write and type almost as well as ever. And I have no tremor. My walking improved dramatically as well – I could walk a mile or more first thing in the morning after taking my medication. But I would be off a substantial part of the day. I was taking one pill at 5 AM, 9 AM, noon, 3 PM, 6 PM, and 9 PM. In the fall of 2008 I went to taking two pills at 5 AM, 8 AM, and 1 PM. This improved my walking considerably.
Cost: < $25 monthly
Side effects: jerky movements, drowsiness

  • 0 helpful marks
Last updated:
Showing 3 of 133 patient evaluations for Carbidopa-Levodopa