What is Pyridostigmine?

Category: Prescription Drugs

Most popular types: Mestinon Mestinon Timespan Kalymin 60N

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Pyridostigmine is an acetylcholinesterase inhibitor used for the symptomatic treatment of myaesthenia gravis and as an antidote for nondepolarizing neuromuscular blockers.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Myasthenia Gravis 120 68
Fatigue 15 9
Lambert-Eaton Myasthenic Syndrome 7 1
POTS (Postural Orthostatic Tachycardia Syndrome) 7 4
ALS (Amyotrophic Lateral Sclerosis) 5 1
Drooping eyelid (ptosis) 4 3

Show all 56 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 6
Moderate 19
Mild 25
None 46

Commonly reported side effects and conditions associated with Pyridostigmine

Side effect Patients
Diarrhea 17
Nausea 5
Sweating 3
Abdominal pain 2
Excess saliva 2
Loose bowel movements 2

Show all 43 reported side effects

Dosages

Based on patients currently taking Pyridostigmine

Dosage Patients
180 mg daily 5
60 mg daily 4
60 mg three times daily 4
60 mg four times daily 4
180 mg three times daily 3
30 mg three times daily 2
120 mg twice daily 2
90 mg three times daily 2
90 mg four times daily 2
15 mg three times daily 1

See all 23 dosages

Why patients stopped taking Pyridostigmine

Multiple reasons could be selected

Reason Patients
Did not seem to work 16
Side effects too severe 10
Doctor's advice 9
Other 7
Expense 2
Course of treatment ended 1
See all 32 patients who’ve stopped taking Pyridostigmine

Duration

Currently taking Pyridostigmine

Duration Patients
1 - 6 months 1
6 months - 1 year 2
1 - 2 years 4
2 - 5 years 20
5 - 10 years 7
10 years or more 6

Stopped taking Pyridostigmine

Duration Patients
Less than 1 month 6
1 - 6 months 9
6 months - 1 year 7
1 - 2 years 3
2 - 5 years 4
5 - 10 years 2
10 years or more 1
Adherence
Adherence Evaluations
Always 64
Usually 21
Sometimes 6
Never taken as prescribed 5
Burden
Burden Evaluations
Very hard to take 5
Somewhat hard to take 7
A little hard to take 16
Not at all hard to take 68
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 1
$50-99 1
$25-49 15
< $25 27
Not specified 51

What people switch to and from

Patients started taking Pyridostigmine after stopping:

Treatment Patients
Meclizine (Antivert) 1
Prednisone (Deltasone) 1
Senna (Senokot) 1

Patients stopped taking Pyridostigmine and switched to:

Treatment Patients
Droxidopa (Northera) 1
Last updated:

3 patient evaluations for Pyridostigmine

69 members have decided to share their profiles only with other members of PatientsLikeMe.

tarheel
965 thumb
tarheel
Sex: M
Data Quality: 0 stars
Bulbar: severe
Arms: severe
Chest: moderate
Legs: mild
I am: n
I have:
ALS

See tarheel's full Pyridostigmine history

Mar 1, 2011 (Started Aug 01, 2006)

  • Effectiveness
    None (for Fatigue)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
drumstix
Portrait default thumb
drumstix
Data Quality: 0 stars
  • Gender: F
  • Age: 62
Condition:
Quality of life:
  • Mental: Unreported
  • Physical: Unreported

See drumstix's full Pyridostigmine history

Apr 8, 2009 (Started Apr 08, 2009)

  • Effectiveness
    Moderate (for Other)
  • Effectiveness
    Moderate (for Fatigue)
  • Effectiveness
    None (for Double vision (diplopia))
  • Side effects
    Moderate (Excess mucus)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 30 mg All the time (24/7)
Advice & Tips: The doctor prescribed way too much for me initially. I was to take 60 mg every four hours, well by the second dose I had 120 mg and I was rigid, weak, could not form words with my mouth and tongue, I sounded like I inhaled helium, my face muscles were not working together....I hyperventilated and my anxiety shot through the roof !A trip to the ER, with several IV's and a re-evaluation over the phone with the doc. I now take 1/2-1 30mg tablet as needed. I am monitoring symptoms...no vision improvement but it does help with speaking, choking and neck pain.
Cost: $50-99 monthly
Side effects: Excess mucus

  • 0 helpful marks
ashfieb
21 thumb
ashfieb
Sex: M
Data Quality: 0 stars
Bulbar: none
Arms: moderate
Chest: none
Legs: mild
I have:
ALS

See ashfieb's full Pyridostigmine history

Aug 19, 2008 (Started Dec 17, 2005)

  • Effectiveness
    Major (for Other)
  • Effectiveness
    None (for Atrophy of upper body muscles)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 180 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 3 patient evaluations for Pyridostigmine