What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6399 3238
Depressed mood 2092 1240
Major depressive disorder 1941 1188
Generalized anxiety disorder 803 576
Myalgic encephalomyelitis/chronic fatigue syndrome 692 385
Pain 540 321

Show all 312 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 938
Moderate 1027
Mild 1160
None 1794

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 335
Nausea 289
Decreased sex drive (libido) 185
Dry mouth 170
Dizziness 160
Brain fog 116

Show all 568 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 353
30 mg daily 141
120 mg daily 114
90 mg daily 68
60 mg twice daily 66
20 mg daily 43
30 mg twice daily 24
40 mg daily 14
20 mg twice daily 10
120 mg twice daily 10

See all 40 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1761
Did not seem to work 1563
Doctor's advice 592
Expense 445
Other 437
Personal research 177
Change in health plan coverage 162
Course of treatment ended 70
See all 3512 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 3
1 - 6 months 39
6 months - 1 year 34
1 - 2 years 108
2 - 5 years 281
5 - 10 years 284
10 years or more 161

Stopped taking Duloxetine

Duration Patients
Less than 1 month 816
1 - 6 months 936
6 months - 1 year 554
1 - 2 years 497
2 - 5 years 528
5 - 10 years 159
10 years or more 39
Adherence
Adherence Evaluations
Always 4117
Usually 437
Sometimes 75
Never taken as prescribed 290
Burden
Burden Evaluations
Very hard to take 306
Somewhat hard to take 374
A little hard to take 577
Not at all hard to take 3662
Cost per month
Cost per month Evaluations
$200+ 125
$100-199 190
$50-99 435
$25-49 692
< $25 1594
Not specified 1883

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 152
Fluoxetine (Prozac) 135
Venlafaxine (Effexor XR) 127
Sertraline (Zoloft) 116
Citalopram (Celexa) 100

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 78
Venlafaxine (Effexor XR) 69
Gabapentin (Neurontin) 59
Escitalopram (Lexapro) 39
Bupropion (Wellbutrin XL) 37

Show all 75 treatments patients report switching to

Last updated:

320 patient evaluations for Duloxetine

Jul 24, 2018 (Started Jul 01, 2014)

  • Effectiveness
    Moderate (for post-traumatic stress disorder)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Major (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: A couple of months ago doctor Gregory added flu achsa teen and decreased duloxetine to 60 milligrams at HS.

Jul 27, 2017 (Started Jul 01, 2014)

  • Effectiveness
    Can't tell (for post-traumatic stress disorder)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Can't tell (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: just take as directed.

  • 0 helpful marks

Jun 6, 2018 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I still think there is some kind of regulating interaction between Cymbalta and carbidopa-L-dopa. And I still can't explain or predict the sunlight /length of day effects.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Sep 30, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: The Psych Dr recommended adding 30mg Cymbalta later in the day when the 60 mg dose is used up. Not sure if and when I wil dose up to 120 mg.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Mar 6, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I am on 2x60mg and tried to cut back to 1x in mid February. That was too soon. Also, I am waking up in the daylight hours, and am not working at UTC anymore. I am trying not to use modafinil for wakefulness.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Sep 23, 2016 (Started Apr 15, 2014)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Moderate (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I have gone up in dosage from 60mg/day to 120mg/day, since Sept 1. Since I am ahead of my usual "sometime in Sept -Oct"schedule, Psychiatrist called it prophylactic. Said to call his office if I need to change med schedule. Aass for cost, I have met my yearly out-of-pocket, so i pay nothing.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Feb 1, 2015 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am taking 2x60mg at night, and 0.75 L-dopa every 4.25 hrs.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

May 11, 2014 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Moderate (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I have noticed that when taking 2x60mg, the L-dopa 25/100 can be taken 4-5 hours. When taking 60mg Cymbalta, the L-dopa is about 3-4hrs. IS it regulating the release? I like the 2x60mg. I wonder if it is causing sleepiness as I usually cut dosage in the SPringtime. It will take weeks to figure this out. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

Apr 18, 2013 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I will take this until the effectivess goes away.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

Aug 23, 2011 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Moderate (excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: Cymbalta has been working for me for dysthymia.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

  • 0 helpful marks

Nov 16, 2017 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for pain)
  • Side effects
    Moderate (brain fog)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for pain)
  • Side effects
    Severe (brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can't tell (for pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 320 patient evaluations for Duloxetine