What is Trihexyphenidyl?

Category: Prescription Drugs

Most popular types: Artane Benzhexol Trihexyphen Show all

false

See also: Risperidone-Trihexyphenidyl Rispond Plus

Trihexyphenidyl is anti-Parkinson's and anticholinergic agent used as adjunctive treatment of Parkinson's disease and for the treatment of drug-induced extrapyramidal symptoms.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 77 44
Tremor in hands 28 21
Tremor(s) 15 10
Restlessness (akathisia) 4 3
Dystonia 3 5
Stiffness/spasticity 3 2

Show all 30 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 15
Moderate 29
Mild 25
None 19

Commonly reported side effects and conditions associated with Trihexyphenidyl

Side effect Patients
Cognitive confusion 9
Dry mouth 6
Word fishing 6
Sleepiness 4
Sleep problems 4
Dizziness 3

Show all 51 reported side effects

Dosages

Based on patients currently taking Trihexyphenidyl

Dosage Patients
2 mg twice daily 3
2 mg daily 2
1 mg daily 1
2 mg/5 mL daily 1
3 other daily 1
2 mg three times daily 1
3 mg three times daily 1
2 mg as needed 1

Why patients stopped taking Trihexyphenidyl

Multiple reasons could be selected

Reason Patients
Side effects too severe 26
Did not seem to work 16
Doctor's advice 16
Other 10
Course of treatment ended 3
Personal research 3
Expense 1
See all 57 patients who've stopped taking Trihexyphenidyl

Duration

Currently taking Trihexyphenidyl

Duration Patients
6 months - 1 year 1
1 - 2 years 1
2 - 5 years 3
5 - 10 years 6
10 years or more 1

Stopped taking Trihexyphenidyl

Duration Patients
Less than 1 month 6
1 - 6 months 17
6 months - 1 year 10
1 - 2 years 11
2 - 5 years 11
5 - 10 years 1
10 years or more 3
Adherence
Adherence Evaluations
Always 58
Usually 22
Sometimes 3
Never taken as prescribed 5
Burden
Burden Evaluations
Very hard to take 3
Somewhat hard to take 5
A little hard to take 19
Not at all hard to take 61
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 1
$50-99 0
$25-49 5
< $25 53
Not specified 29

What people switch to and from

Patients started taking Trihexyphenidyl after stopping:

Treatment Patients
Gabapentin (Neurontin) 1
Hydroxyzine (Vistaril) 1
Propranolol (Inderal) 1
Ropinirole (Requip) 1

Patients stopped taking Trihexyphenidyl and switched to:

Treatment Patients
Amantadine (Symmetrel) 2
Baclofen (Mylan-Baclofen) 1
Carbidopa-Levodopa (Sinemet) 1
Cyclobenzaprine (Flexeril) 1
Entacapone (Comtan) 1

Show all 7 treatments patients report switching to

Last updated:

10 patient evaluations for Trihexyphenidyl

Jan 9, 2016 (Started Dec 20, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 6 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

May 13, 2012 (Started Apr 28, 2010)

  • Effectiveness
    Moderate (for pd was progressing)
  • Side effects
    Moderate (complete exhaustion, anxious mood)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Daily
Advice & Tips: lots of great changes at first, bladder control, sleeping better, less tremoring
Cost: < $25 monthly

  • 0 helpful marks

Mar 25, 2011 (Started Oct 12, 2003)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Severe (loss of short term memory, cognitive confusion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: I stopped Artane March 2011...the short term memory was causing some major problems in my life
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

Jan 3, 2011 (Started Oct 12, 2003)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (loss of short term memory, cognitive confusion)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 20 mg Daily
Advice & Tips: Artane definitely helps with my tremors but it also cause some short term memory problems
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

Apr 2, 2010 (Started Oct 12, 2003)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (loss of short term memory, cognitive confusion)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 20 mg Daily
Advice & Tips: I was off Artane for several months, by my request. I started again because my tremors started getting bad again. I did not see any improvement in my memory loss while I was off of the artane
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

Nov 20, 2009 (Started Oct 12, 2003)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Severe (cognitive confusion)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 20 mg Daily
Advice & Tips: Started taking Artane when diagnosed. It helped my tremors, but had a devastating effect on my short term memory. My neuro and I felt like it was time to start weaning me off of Artane on Oct 29,2009. I took my last dose morning of Nov 20, 2009. Went from 5mgs 4xdaily to 2.5 mgs 1xday over 3 weeks. Have not seen any real improvement over short term memory loss but over all feel better physically. My tremors have not increased significantly enough to warrant going back to Artane.
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

  • 1 helpful mark
Last updated:
Showing 3 of 10 patient evaluations for Trihexyphenidyl