What is Carbidopa-Entacapone-Levodopa?

Category: Prescription Drugs

Most popular types: Stalevo Stalevo 100 Stalevo 150 Show all

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The combination of levodopa, carbidopa, and entacapone is used for Parkinson's Disease. Levodopa is the precursor to dopamine, carbidopa slows the breakdown of levodopa, while entacapone improves the efficacy of levodopa.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 629 287
Stiffness/spasticity 21 15
Increase effect of another treatment 14 12
Improve mobility 5 4
Slow movement (bradykinesia) 3 0
Tremor in hands 3 2

Show all 26 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 32
Moderate 67
Mild 74
None 125

Commonly reported side effects and conditions associated with Carbidopa-Entacapone-Levodopa

Side effect Patients
Jerky movements 36
Nausea 15
Cramps in legs 8
Dry mouth 7
Weight gain 6
Fatigue 5

Show all 87 reported side effects

Dosages

Based on patients currently taking Carbidopa-Entacapone-Levodopa

Dosage Patients
3 x 25 mg-200 mg-100 mg daily 7
25 mg-200 mg-100 mg daily 6
37.5-200-150 mg four times daily 5
25 mg-200 mg-100 mg four times daily 4
25-200-100 mg four times daily 3
5 x 25-200-100 mg daily 3
25 mg-200 mg-100 mg five times daily 3
4 x 37.5 mg-200 mg-150 mg daily 3
5 x 37.5 mg-200 mg-150 mg daily 3
31.25-200-125 mg three times daily 2

See all 60 dosages

Why patients stopped taking Carbidopa-Entacapone-Levodopa

Multiple reasons could be selected

Reason Patients
Side effects too severe 70
Doctor's advice 64
Did not seem to work 39
Other 33
Expense 21
Personal research 9
Change in health plan coverage 3
Course of treatment ended 1
See all 191 patients who've stopped taking Carbidopa-Entacapone-Levodopa

Duration

Currently taking Carbidopa-Entacapone-Levodopa

Duration Patients
1 - 6 months 2
6 months - 1 year 3
1 - 2 years 6
2 - 5 years 19
5 - 10 years 43
10 years or more 23

Stopped taking Carbidopa-Entacapone-Levodopa

Duration Patients
Less than 1 month 27
1 - 6 months 58
6 months - 1 year 36
1 - 2 years 22
2 - 5 years 47
5 - 10 years 12
10 years or more 3
Adherence
Adherence Evaluations
Always 225
Usually 55
Sometimes 7
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 16
Somewhat hard to take 32
A little hard to take 63
Not at all hard to take 187
Cost per month
Cost per month Evaluations
$200+ 19
$100-199 15
$50-99 29
$25-49 44
< $25 94
Not specified 97

What people switch to and from

Patients started taking Carbidopa-Entacapone-Levodopa after stopping:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 32
Ropinirole (Requip) 8
Carbidopa Levodopa ER (Rytary XR) 3
Amantadine (Symmetrel) 2
Pramipexole (Mirapex) 2

Show all 11 treatments patients report switching from

Patients stopped taking Carbidopa-Entacapone-Levodopa and switched to:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 13
Carbidopa Levodopa ER (Rytary XR) 9
Entacapone (Comtan) 3
Carbidopa-Levodopa CR (Sinemet CR) 2
Pramipexole (Mirapex) 2

Show all 8 treatments patients report switching to

Last updated:

42 patient evaluations for Carbidopa-Entacapone-Levodopa

Jun 29, 2008 (Started May 28, 2008)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    Severe (confusion, nausea, fatigue)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 500 mg Daily
Cost: < $25 monthly
Side effects: confusion, fatigue, nausea

  • 0 helpful marks

Sep 11, 2007 (Started Sep 11, 2005)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (jerky movements, wired, nausea)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Advice & Tips: IT CAN BE SOMEWHAT "SPEEDY" LIKE A CAFFEINE OVERDOSE BUT WORTH THE MOBILITY
Cost: $200+ monthly
Side effects: jerky movements, wired, nausea

  • 0 helpful marks

Oct 5, 1992 (Started Oct 05, 1992)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 12.5 mg-200 mg-50 mg Daily
Advice & Tips: I have no clue, I never tried it and do not know how it got in my profile.

  • 0 helpful marks
Last updated:
Showing 3 of 42 patient evaluations for Carbidopa-Entacapone-Levodopa