What is Bupropion XL?

Category: Prescription Drugs

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Generic name: Bupropion

Bupropion XL is an extended-release version of bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) used for the treatment of depression. It is also used for the prevention of seasonal affective disorder.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 190 151
Depressed mood 159 129
Persistent depressive disorder (dysthymia) 43 49
Bipolar II disorder 16 23
Bipolar disorder 10 21
Generalized anxiety disorder 10 24

Show all 57 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 21
Moderate 48
Mild 85
None 132

Commonly reported side effects and conditions associated with Bupropion XL

Side effect Patients
Dry mouth 16
Anxious mood 10
Decreased appetite 9
Weight gain 7
Headaches 6
Irritability 6

Show all 91 reported side effects

Dosages

Based on patients currently taking Bupropion XL

Dosage Patients
300 mg daily 44
150 mg daily 34
300 mg/24 hours daily 17
450 mg daily 13
150 mg twice daily 6
75 mg daily 3
150 mg/24 hours daily 3
200 mg twice daily 2
100 mg twice daily 1
200 mg daily 1

See all 17 dosages

Why patients stopped taking Bupropion XL

Multiple reasons could be selected

Reason Patients
Did not seem to work 30
Side effects too severe 27
Doctor's advice 24
Other 10
Personal research 8
Expense 5
Course of treatment ended 4
Change in health plan coverage 1
See all 82 patients who've stopped taking Bupropion XL

Duration

Currently taking Bupropion XL

Duration Patients
Less than 1 month 1
1 - 6 months 9
6 months - 1 year 11
1 - 2 years 22
2 - 5 years 28
5 - 10 years 30
10 years or more 30

Stopped taking Bupropion XL

Duration Patients
Less than 1 month 5
1 - 6 months 20
6 months - 1 year 9
1 - 2 years 19
2 - 5 years 13
5 - 10 years 12
10 years or more 5
Adherence
Adherence Evaluations
Always 216
Usually 63
Sometimes 5
Never taken as prescribed 2
Burden
Burden Evaluations
Very hard to take 3
Somewhat hard to take 10
A little hard to take 38
Not at all hard to take 235
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 2
$50-99 11
$25-49 27
< $25 166
Not specified 79

What people switch to and from

Patients started taking Bupropion XL after stopping:

Treatment Patients
Sertraline (Zoloft) 9
Venlafaxine (Effexor XR) 9
Fluoxetine (Prozac) 5
Bupropion (Wellbutrin XL) 4
Duloxetine (Cymbalta) 4

Show all 29 treatments patients report switching from

Patients stopped taking Bupropion XL and switched to:

Treatment Patients
Fluoxetine (Prozac) 4
Bupropion (Wellbutrin XL) 1
Buspirone (BuSpar) 1
Citalopram (Celexa) 1
Imipramine (Tofranil) 1

Show all 13 treatments patients report switching to

Last updated:

26 patient evaluations for Bupropion XL

Dec 15, 2017 (Started Jun 01, 2006)

  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    Severe (insomnia, hot flashes, feeling tense or on edge, feeling feverish, facial flushing)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Advice & Tips: If you are taking the generic extended release make sure it is not dose dumping - releasing too much medicine at once causing side effects. My MS doctor, PCP, and I thought I was in menopause with all the hot flashes and fevers of 99.6! Even kept going in to see if I had a UTI bc of the fevers! What a waste of my time and money!!!
Cost: < $25 monthly

  • 0 helpful marks

May 23, 2017 (Started Jul 01, 2001)

  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily

Jan 28, 2001 (Started Jul 01, 2001)

  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily

  • 0 helpful marks

Dec 24, 2015 (Started Apr 11, 2013)

  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 26 patient evaluations for Bupropion XL