What is Bupropion XL?

Category: Prescription Drugs

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Generic name: Bupropion

Bupropion XL is an extended-release version of bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) used for the treatment of depression. It is also used for the prevention of seasonal affective disorder.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 181 141
Depressed mood 151 122
Persistent depressive disorder (dysthymia) 37 43
Bipolar II disorder 15 19
Anxious mood 10 4
Bipolar disorder 9 20

Show all 59 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
19
Moderate
45
Mild
76
None
125

Commonly reported side effects and conditions associated with Bupropion XL

Side effect Patients
Dry mouth 12
Anxious mood 10
Decreased appetite 7
Weight gain 7
Headaches 6
Irritability 6

Show all 92 reported side effects

Dosages

Based on patients currently taking Bupropion XL

Dosage Patients
300 mg daily 46
150 mg daily 33
300 mg/24 hours daily 17
450 mg daily 11
150 mg twice daily 6
75 mg daily 3
100 mg twice daily 2
150 mg three times daily 2
19.5 mg every other day 1
5 mg three times daily 1

See all 16 dosages

Why patients stopped taking Bupropion XL

Multiple reasons could be selected

Reason Patients
Side effects too severe 26
Did not seem to work 25
Doctor's advice 24
Other 10
Personal research 8
Course of treatment ended 4
Expense 4
Change in health plan coverage 1
See all 78 patients who've stopped taking Bupropion XL

Duration

Currently taking Bupropion XL

Duration Patients
1 - 6 months 17
6 months - 1 year 11
1 - 2 years 16
2 - 5 years 28
5 - 10 years 29
10 years or more 27

Stopped taking Bupropion XL

Duration Patients
Less than 1 month 5
1 - 6 months 19
6 months - 1 year 9
1 - 2 years 17
2 - 5 years 14
5 - 10 years 12
10 years or more 3
Adherence
Adherence Evaluations
Always 200
Usually 59
Sometimes 5
Never taken as prescribed 1
Burden
Burden Evaluations
Very hard to take 3
Somewhat hard to take 10
A little hard to take 37
Not at all hard to take 215
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 2
$50-99 11
$25-49 25
< $25 155
Not specified 71

What people switch to and from

Patients started taking Bupropion XL after stopping:

Treatment Patients
Sertraline (Zoloft) 8
Venlafaxine (Effexor XR) 8
Fluoxetine (Prozac) 5
Duloxetine (Cymbalta) 4
Escitalopram (Lexapro) 4

Show all 28 treatments patients report switching from

Patients stopped taking Bupropion XL and switched to:

Treatment Patients
Fluoxetine (Prozac) 2
Bupropion (Wellbutrin XL) 1
Citalopram (Celexa) 1
Imipramine (Tofranil) 1
Lamotrigine (Lamictal) 1

Show all 11 treatments patients report switching to

Last updated:

25 patient evaluations for Bupropion XL

May 23, 2017 (Started Jul 01, 2001)

  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily

Jan 28, 2001 (Started Jul 01, 2001)

  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily

  • 0 helpful marks

Dec 24, 2015 (Started Apr 11, 2013)

  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Cost: < $25 monthly

  • 0 helpful marks

Feb 1, 2015 (Started Mar 01, 1990)

  • Effectiveness
    Slight (for bipolar disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 450 mg Daily
Advice & Tips: I started Wellbutrin in 1989, before there was a generic. It worked very well for me until a couple of years ago, when I became convinced it was doing less for my depression, and more to make me anxious. My healthcare provider agreed that was a reasonable assessment. When I started Latuda, and it was a success, we decided to titrate off the Buproprion. I have not had difficulty since I quit it, although my anxiety level is still a little high.
Cost: < $25 monthly

Mar 17, 2010 (Started Mar 01, 1990)

  • Effectiveness
    Major (for bipolar disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 x 150 mg/24 hours Daily
Cost: < $25 monthly

Mar 3, 2010 (Started Mar 01, 1990)

  • Effectiveness
    Major (for bipolar disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 2 x 150 mg/24 hours Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 25 patient evaluations for Bupropion XL