What is Bupropion XL?

Category: Prescription Drugs

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Generic name: Bupropion

Bupropion XL is an extended-release version of bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) used for the treatment of depression. It is also used for the prevention of seasonal affective disorder.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 196 155
Depressed mood 159 127
Persistent depressive disorder (dysthymia) 43 49
Bipolar II disorder 16 24
Bipolar disorder 10 21

Show all 53 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 21
Moderate 47
Mild 88
None 132

Commonly reported side effects and conditions associated with Bupropion XL

Side effect Patients
Dry mouth 16
Decreased appetite 10
Anxious mood 9
Weight gain 7
Headaches 6
Irritability 6

Show all 83 reported side effects

Dosages

Based on patients currently taking Bupropion XL

Dosage Patients
300 mg daily 44
150 mg daily 23
300 mg/24 hours daily 15
450 mg daily 14
150 mg twice daily 6
150 mg/24 hours daily 3
100 mg twice daily 2
75 mg daily 1
100 mg daily 1
200 mg daily 1

See all 16 dosages

Why patients stopped taking Bupropion XL

Multiple reasons could be selected

Reason Patients
Did not seem to work 30
Side effects too severe 28
Doctor's advice 26
Other 12
Personal research 8
Expense 5
Course of treatment ended 4
Change in health plan coverage 1
See all 86 patients who've stopped taking Bupropion XL

Duration

Currently taking Bupropion XL

Duration Patients
1 - 6 months 4
6 months - 1 year 5
1 - 2 years 26
2 - 5 years 33
5 - 10 years 28
10 years or more 20

Stopped taking Bupropion XL

Duration Patients
Less than 1 month 5
1 - 6 months 22
6 months - 1 year 9
1 - 2 years 19
2 - 5 years 13
5 - 10 years 13
10 years or more 6
Adherence
Adherence Evaluations
Always 216
Usually 64
Sometimes 5
Never taken as prescribed 3
Burden
Burden Evaluations
Very hard to take 3
Somewhat hard to take 10
A little hard to take 37
Not at all hard to take 238
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 2
$50-99 12
$25-49 29
< $25 166
Not specified 78

What people switch to and from

Patients started taking Bupropion XL after stopping:

Treatment Patients
Sertraline (Zoloft) 9
Venlafaxine (Effexor XR) 9
Fluoxetine (Prozac) 5
Bupropion (Wellbutrin XL) 4
Duloxetine (Cymbalta) 4

Show all 28 treatments patients report switching from

Patients stopped taking Bupropion XL and switched to:

Treatment Patients
Fluoxetine (Prozac) 4
Bupropion (Wellbutrin XL) 1
Buspirone (BuSpar) 1
Citalopram (Celexa) 1
Imipramine (Tofranil) 1

Show all 13 treatments patients report switching to

Last updated:

26 patient evaluations for Bupropion XL

Sep 28, 2018 (Started Mar 26, 2012)

  • Effectiveness
    None (for depressed mood)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Cost: < $25 monthly

Jun 28, 2010 (Started Mar 26, 2012)

  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: The Drs put me on Wellbutrin XL because with Effexor I have very little sexual desires and Wellbutrin is less invaseave.
Cost: < $25 monthly

  • 0 helpful marks

Dec 15, 2017 (Started Jun 01, 2006)

  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    Severe (feeling tense or on edge, insomnia, hot flashes, feeling feverish, facial flushing)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Advice & Tips: If you are taking the generic extended release make sure it is not dose dumping - releasing too much medicine at once causing side effects. My MS doctor, PCP, and I thought I was in menopause with all the hot flashes and fevers of 99.6! Even kept going in to see if I had a UTI bc of the fevers! What a waste of my time and money!!!
Cost: < $25 monthly

  • 0 helpful marks

May 23, 2017 (Started Jul 01, 2001)

  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily

Jan 28, 2001 (Started Jul 01, 2001)

  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 26 patient evaluations for Bupropion XL