What is Tizanidine?

Category: Prescription Drugs

Most popular types: Zanaflex Sirdalud Sirdalud Retard Show all

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Tizanidine hydrochloride is a skeletal muscle relaxant used for treatment of muscle spasticity. It may also be used for tension headaches, low back pain, and trigeminal neuralgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Stiffness/Spasticity 835 305
Muscle spasms 652 247
Fibromyalgia 319 111
Muscle pain 86 30
Pain 82 44
Muscle spasms in neck and shoulders 56 12

Show all 162 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 64
Moderate 160
Mild 171
None 252

Commonly reported side effects and conditions associated with Tizanidine

Side effect Patients
Sleepiness 72
Drowsiness 56
Dry mouth 46
Fatigue 26
Excessive daytime sleepiness (somnolence) 21
Dry eyes 17

Show all 122 reported side effects

Dosages

Based on patients currently taking Tizanidine

Dosage Patients
4 mg daily 62
8 mg daily 29
2 mg daily 25
4 mg twice daily 21
4mg as needed 21
12 mg daily 20
4 mg three times daily 19
2 mg three times daily 14
6 mg daily 12
2mg as needed 10

See all 38 dosages

Why patients stopped taking Tizanidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 150
Side effects too severe 85
Other 74
Doctor's advice 72
Course of treatment ended 19
Personal research 16
Expense 12
Change in health plan coverage 8
See all 358 patients who’ve stopped taking Tizanidine

Duration

Currently taking Tizanidine

Duration Patients
Less than 1 month 4
1 - 6 months 19
6 months - 1 year 39
1 - 2 years 43
2 - 5 years 77
5 - 10 years 81
10 years or more 38

Stopped taking Tizanidine

Duration Patients
Less than 1 month 55
1 - 6 months 100
6 months - 1 year 55
1 - 2 years 58
2 - 5 years 56
5 - 10 years 26
10 years or more 10
Adherence
Adherence Evaluations
Always 449
Usually 117
Sometimes 58
Never taken as prescribed 23
Burden
Burden Evaluations
Very hard to take 31
Somewhat hard to take 34
A little hard to take 93
Not at all hard to take 489
Cost per month
Cost per month Evaluations
$200+ 3
$100-199 0
$50-99 15
$25-49 42
< $25 358
Not specified 229

What people switch to and from

Patients started taking Tizanidine after stopping:

Treatment Patients
Cyclobenzaprine (Flexeril) 38
Baclofen (Mylan-Baclofen) 25
Carisoprodol (Soma) 12
Diazepam (Valium) 3
Hydrocodone-Acetaminophen (Norco) 3

Show all 28 treatments patients report switching from

Patients stopped taking Tizanidine and switched to:

Treatment Patients
Baclofen (Mylan-Baclofen) 21
Cyclobenzaprine (Flexeril) 7
Diazepam (Valium) 3
Baclofen intrathecal pump (Lioresal) 2
Clonazepam (Klonopin) 2

Show all 18 treatments patients report switching to

Last updated:

86 patient evaluations for Tizanidine

497 members have decided to share their profiles only with other members of PatientsLikeMe.

slowrambler
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slowrambler
Sex: M
Data Quality: 2 stars
Relapse: Moderate
Sensation: Moderate
Overall: Mild
Cognition: none
Vision: none
Speech: none
Swallowing: none
Upper limb: none
Walking: severe
I am: g
I have:
MS

See slowrambler's full Tizanidine history

Mar 5, 2017 (Started Sep 10, 1999)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Muscle fatigue, Dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Sep 7, 2012 (Started Sep 10, 1999)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Feb 9, 2009 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Sep 7, 2008 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for Stiffness/Spasticity)
  • Side effects
    Mild (Muscle fatigue, Dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: This medication served me very well for several yrs. after I'd exhausted the use of Baclofen, which had become totally ineffective for me. This medication is not instant in terms of effectiveness. I had to "wean off" of the Baclofen & "ramp up" the dosage of Zanaflex & maintain a consistent level of this medication (in my bloodstream) before it became truly effective. After it became ineffective singularly, I began using it in combination with Keppra & I'm still realizing positive results using this regimen. I do experience some minor muscle fatigue & occasional dry mouth while using Zanaflex, however nothing close in terems of negative side effects as compared to Baclofen.
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

  • 0 helpful marks
thjuland
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thjuland
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: none
Speech: none
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: n
I have:
MS

See thjuland's full Tizanidine history

Nov 30, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 24 mg Daily
Advice & Tips: I increased the dosage to 6 mg four times a day, because of increased left leg/foot spasticity in the evening.
Cost: < $25 monthly

Mar 25, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: Still effective for relief of spasticity and I usually bypass the sleepiness by spacing doses at 4 hour intervals.
Cost: < $25 monthly

Sep 21, 2015 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: it's very effective for relief of spasticity, unfortunately it puts me into a deep sleep.
Cost: < $25 monthly

Oct 8, 2014 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 12 mg Daily
Advice & Tips: none, i sleep as needed.
Cost: < $25 monthly

  • 0 helpful marks
firefly84
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firefly84
Data Quality: 3 stars
  • Gender: F
  • Age: 32
Condition: Autonomic Neuropathy 25 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Moderate
I am: n
I have:
Autonomic Neuropathy

See firefly84's full Tizanidine history

Aug 30, 2016 (Started Jul 15, 2013)

  • Effectiveness
    Moderate (for Stiffness/Spasticity)
  • Effectiveness
    Moderate (for Neck pain)
  • Side effects
    Mild (Drowsiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 3 of 86 patient evaluations for Tizanidine