What is Phenelzine?

Category: Prescription Drugs

Most popular types: Nardil

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Phenelzine is a monoamine oxidase inhibitor, used to treat depression. It comes as a tablet to take by mouth and is usually taken three times a day.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 9 12
Depressed mood 4 3
Social anxiety 3 2
Anxious mood 2 4
Migraine headaches 2 1
Bipolar disorder 1 1

Show all 10 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 9
Moderate 7
Mild 8
None 1

Commonly reported side effects and conditions associated with Phenelzine

Side effect Patients
Weight gain 6
Difficulty with orgasm 5
Daytime sedation 4
Dietary restrictions 4
Decreased sex drive (libido) 3
Difficulty thinking 3

Show all 29 reported side effects

Dosages

Based on patients currently taking Phenelzine

Dosage Patients
90 mg daily 1
105 mg daily 1

Why patients stopped taking Phenelzine

Multiple reasons could be selected

Reason Patients
Did not seem to work 4
Doctor's advice 4
Other 3
Side effects too severe 2
Personal research 1
See all 10 patients who've stopped taking Phenelzine

Duration

Currently taking Phenelzine

Duration Patients
6 months - 1 year 2

Stopped taking Phenelzine

Duration Patients
1 - 6 months 4
1 - 2 years 2
2 - 5 years 3
5 - 10 years 1
Adherence
Adherence Evaluations
Always 22
Usually 2
Sometimes 0
Never taken as prescribed 1
Burden
Burden Evaluations
Very hard to take 3
Somewhat hard to take 4
A little hard to take 7
Not at all hard to take 11
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 0
$50-99 1
$25-49 3
< $25 11
Not specified 10

What people switch to and from

Patients started taking Phenelzine after stopping:

Treatment Patients
Mirtazapine (Remeron) 1
Paroxetine (Paxil) 1
Propranolol (Inderal) 1
Tranylcypromine (Parnate) 1
Venlafaxine (Effexor XR) 1

Patients stopped taking Phenelzine and switched to:

Treatment Patients
Dextroamphetamine (Dexedrine) 1
Duloxetine (Cymbalta) 1
Lamotrigine (Lamictal) 1
Propranolol (Inderal) 1
Last updated:

5 patient evaluations for Phenelzine

Oct 2, 2012 (Started Jan 23, 2012)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Major (for anxious mood)
  • Effectiveness
    Major (for generalized anxiety disorder)
  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (decreased sex drive (libido), anorgasmia, insomnia, low blood pressure, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: Problems with low blood pressure have lessened a bit over time, but still a big hassle. Now taking extra salt and drinking extra fluids to try to counteract it. I now consider the improvement from increasing the dosage to 60mg to outweigh the side effects.
Cost: < $25 monthly

Aug 8, 2012 (Started Jan 23, 2012)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Major (for anxious mood)
  • Effectiveness
    Major (for generalized anxiety disorder)
  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Severe (decreased sex drive (libido), anorgasmia, insomnia, low blood pressure, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: Increased dosage to 60mg because I was having increased anxiety over the summer (this is my typical seasonal pattern with anxiety). Anxiety is gone, and I have more energy on the rare occasions when my blood pressure isn't below 110/65. Insomnia is also an issue again. At this moment, I'd say the gains against anxiety aren't worth the increased side effects.
Cost: < $25 monthly

Apr 14, 2012 (Started Jan 23, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Side effects
    Mild (decreased sex drive (libido), anorgasmia, insomnia, low blood pressure, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 45 mg Daily
Advice & Tips: Side effects were rather severe at 60mg. At 45mg I'm experiencing only occasional slightly lowered blood pressure and mild to moderate insomnia
Cost: < $25 monthly

  • 0 helpful marks

Feb 4, 2009 (Started Jan 19, 2009)

  • Effectiveness
    None (for Treat my mood condition(s))
  • Side effects
    Mild (dietary restrictions, decreased sex drive (libido))
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 45 mg Daily
Cost: $25-49 monthly
Side effects: dietary restrictions, decreased sex drive (libido)

  • 0 helpful marks

Jan 19, 2009 (Started Dec 01, 2008)

  • Effectiveness
    Major (for Other)
  • Side effects
    Mild (difficulty thinking, dietary restrictions, daytime sedation, drug interactions, difficulty with orgasm, weight gain, memory problems, insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: it's important to stick with nardil as there will be side effects but just hang in there. take the med the same times everyday (ie set a cellphone alarm). for many there is a "bliss" or euphoric experience in the first 2 weeks lasting 4 or 5 days for me (mine was at 45mg - my starting dose - and happened within 2-3 days of starting nardil) but this bliss doesnt last (dont confuse it for the med kicking in) as this "side effect" will go away and negative ones will return. the real med response comes later (for me 60mg for two weeks making a total of 1 month on the med)...comes as a feeling of calm, muscle relaxing, head clearing, and brightening of mood...all of which were quite dramatic and rapid at 1 month in for me. I still have down days but by far, my moods and anxiety are much improved.
Side effects: difficulty thinking, daytime sedation, dietary restrictions, insomnia, drug interactions, difficulty with orgasm, memory problems, weight gain, problems concentrating

  • 0 helpful marks
Last updated:
Showing 3 of 5 patient evaluations for Phenelzine