What is Dalfampridine?

Category: Prescription Drugs

Most popular types: Ampyra Fampyra

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Dalfampridine is an extended release formulation of 4-aminopyridine or 4-AP. It is a potassium channel blocker that is used as a treatment to improve walking in patients with multiple sclerosis (MS). Dalfampridine was previously called Fampridine-SR during clinical trials.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 870 682
Walking problems 490 541
Improve mobility 300 322
Improve flexibility/strength 33 41
Fatigue 32 30
Balance problems 28 34

Show all 43 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 53
Moderate 70
Mild 177
None 620

Commonly reported side effects and conditions associated with Dalfampridine

Side effect Patients
Insomnia 29
Dizziness 21
Nausea 16
Balance problems 11
Constipation 11
Headaches 11

Show all 134 reported side effects

Dosages

Based on patients currently taking Dalfampridine

Dosage Patients
20 mg daily 98
10 mg twice daily 85
10 mg daily 38
2 tablet(s) daily 10
1 tablet(s) twice daily 9
30 mg daily 7
20 mg twice daily 5
2 mg daily 4
15 mg daily 3
60 mg daily 3

See all 34 dosages

Why patients stopped taking Dalfampridine

Multiple reasons could be selected

Reason Patients
Did not seem to work 198
Side effects too severe 109
Other 66
Doctor's advice 53
Expense 50
Change in health plan coverage 15
Course of treatment ended 11
Personal research 9
See all 371 patients who've stopped taking Dalfampridine

Duration

Currently taking Dalfampridine

Duration Patients
1 - 6 months 3
6 months - 1 year 5
1 - 2 years 15
2 - 5 years 70
5 - 10 years 190
10 years or more 10

Stopped taking Dalfampridine

Duration Patients
Less than 1 month 88
1 - 6 months 115
6 months - 1 year 46
1 - 2 years 58
2 - 5 years 55
5 - 10 years 11
10 years or more 4
Adherence
Adherence Evaluations
Always 747
Usually 113
Sometimes 22
Never taken as prescribed 38
Burden
Burden Evaluations
Very hard to take 16
Somewhat hard to take 40
A little hard to take 103
Not at all hard to take 761
Cost per month
Cost per month Evaluations
$200+ 52
$100-199 48
$50-99 94
$25-49 242
< $25 247
Not specified 237

What people switch to and from

Patients started taking Dalfampridine after stopping:

Treatment Patients
Glatiramer acetate (Copaxone) 6
Fampridine (4-AP immediate release) 4
Dimethyl fumarate (Tecfidera) 2
Natalizumab (Tysabri) 2
Interferon beta-1a IM Injection (Avonex) 1

Show all 8 treatments patients report switching from

Patients stopped taking Dalfampridine and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 2
Natalizumab (Tysabri) 2
Amifampridine phosphate (3,4 Diaminopyridine) 1
Bupropion (Wellbutrin XL) 1
Cyclophosphamide (Cytoxan) 1

Show all 9 treatments patients report switching to

Last updated:

80 patient evaluations for Dalfampridine

Oct 9, 2017 (Started Apr 21, 2014)

  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: it was discontinued 1 week after starting because of risk to liver.
Cost: < $25 monthly

  • 0 helpful marks

Jul 2, 2017 (Started Jan 24, 2011)

  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Effectiveness
    Major (for walking problems)
  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily

Mar 5, 2017 (Started Jan 24, 2011)

  • Effectiveness
    Major (for walking problems)
  • Effectiveness
    Slight (for stiffness/spasticity)
  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily

  • 0 helpful marks

Jun 24, 2017 (Started Apr 15, 2012)

  • Effectiveness
    None (for multiple sclerosis)
  • Effectiveness
    Can't tell (for walking problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: Nothing new.
Cost: $100-199 monthly

Mar 28, 2017 (Started Apr 15, 2012)

  • Effectiveness
    Can't tell (for walking problems)
  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: No problem adhering to schedule - one pill every 12 hours. I don't really feel the difference, but my DH and the walking test that I did after 1 year after beginning the treatmentshowed an improvement in speed.
Cost: < $25 monthly

Feb 26, 2015 (Started Apr 15, 2012)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: Easy to take - 2 pills, one morning, second 12 hours later. I walk somewhat faster. I walk more than a few meters with my rollator, otherwise with a stick. I only walk with no help in my house.
Cost: < $25 monthly

Jun 26, 2013 (Started Apr 15, 2012)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: stick with it and stick to the schedule.
Cost: $100-199 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 80 patient evaluations for Dalfampridine