What is Wellbutrin XL?

Category: Prescription Drugs

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Generic name: Bupropion

See also: Wellbutrin

Wellbutrin XL™, a brand name for the extended release version of bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) used to treat major depressive disorder, including seasonal affective disorder (SAD).

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Depressed mood 474 147
Major depressive disorder 304 159
Persistent depressive disorder (dysthymia) 63 41
Anxious mood 46 15
Bipolar disorder 36 23
Fatigue 30 15

Show all 97 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
51
Moderate
67
Mild
104
None
167

Commonly reported side effects and conditions associated with Wellbutrin XL

Side effect Patients
Anxious mood 17
Dry mouth 17
Difficulty sleeping through night 13
Insomnia 12
Nausea 10
Sweating increased 9

Show all 132 reported side effects

Dosages

Based on patients currently taking Wellbutrin XL

Dosage Patients
300 mg daily 46
300 mg/24 hours daily 27
150 mg daily 25
150 mg/24 hours daily 19
450 mg daily 9
100 mg daily 7
2 x 150 mg/24 hours daily 6
3 x 150 mg/24 hours daily 4
200 mg twice daily 3
400 mg daily 2

See all 17 dosages

Why patients stopped taking Wellbutrin XL

Multiple reasons could be selected

Reason Patients
Did not seem to work 109
Side effects too severe 96
Doctor's advice 90
Other 60
Expense 20
Course of treatment ended 14
Personal research 12
Change in health plan coverage 9
See all 289 patients who've stopped taking Wellbutrin XL

Duration

Currently taking Wellbutrin XL

Duration Patients
1 - 6 months 16
6 months - 1 year 18
1 - 2 years 15
2 - 5 years 28
5 - 10 years 43
10 years or more 36

Stopped taking Wellbutrin XL

Duration Patients
Less than 1 month 33
1 - 6 months 92
6 months - 1 year 34
1 - 2 years 44
2 - 5 years 50
5 - 10 years 26
10 years or more 11
Adherence
Adherence Evaluations
Always 312
Usually 58
Sometimes 8
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 12
Somewhat hard to take 25
A little hard to take 58
Not at all hard to take 294
Cost per month
Cost per month Evaluations
$200+ 2
$100-199 9
$50-99 17
$25-49 38
< $25 167
Not specified 156

What people switch to and from

Patients started taking Wellbutrin XL after stopping:

Treatment Patients
Sertraline (Zoloft) 13
Duloxetine (Cymbalta) 12
Citalopram (Celexa) 11
Venlafaxine (Effexor XR) 8
Bupropion (Wellbutrin XL) 6

Show all 24 treatments patients report switching from

Patients stopped taking Wellbutrin XL and switched to:

Treatment Patients
Duloxetine (Cymbalta) 8
Sertraline (Zoloft) 7
Citalopram (Celexa) 4
Lamotrigine (Lamictal) 4
Venlafaxine (Effexor XR) 4

Show all 21 treatments patients report switching to

Last updated:

38 patient evaluations for Wellbutrin XL

Nov 1, 2016 (Started Aug 19, 2016)

  • Effectiveness
    None (for persistent depressive disorder (dysthymia))
  • Side effects
    Severe (serotonin syndrome, night sweats, unrefreshing or poor sleep, constipation, shakiness, hot flashes, brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily

  • 0 helpful marks

Aug 31, 2016 (Started Sep 10, 1997)

  • Effectiveness
    None (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Oct 23, 2015 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Jun 1, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Been back on Wellbutrin 450mg/day for a couple of ears now and, with the addition of 20mg/day of Viibryd I've been very stable.
Cost: < $25 monthly

Mar 11, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: $25-49 monthly

Aug 27, 2008 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Like any antidepressant, you (doctor & patient) have to determine what works for you. I was on various doses of Prozac for several years, but its effect eventually wore off. My psychopharmacologist switched me to Wellbutrin in 1997 and I've been on various doses of it since. Wellbutrin works on the dopamine system in the brain, so I'm curious how it relates to PD (if it does at all).
Cost: < $25 monthly

  • 0 helpful marks

Apr 18, 2016 (Started Mar 29, 2016)

  • Effectiveness
    Moderate (for slow movement (bradykinesia))
  • Effectiveness
    Slight (for problems concentrating)
  • Effectiveness
    Moderate (for overwhelming fatigue)
  • Effectiveness
    None (for major depressive disorder)
  • Effectiveness
    Moderate (for fatigue)
  • Effectiveness
    Moderate (for excessive sleeping (hypersomnia))
  • Effectiveness
    None (for depressed mood)
  • Effectiveness
    Moderate (for apathy)
  • Side effects
    Severe (memory problems, emotional sensitivity, sensory sensitivity, crying for no reason, anxious mood, panic attacks, anger, irritability, heart palpitations)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 150 mg/24 hours Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 38 patient evaluations for Wellbutrin XL