What is Wellbutrin XL?

Category: Prescription Drugs

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Generic name: Bupropion

See also: Wellbutrin

Wellbutrin XL™, a brand name for the extended release version of bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) used to treat major depressive disorder, including seasonal affective disorder (SAD).

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Depressed mood 477 151
Major depressive disorder 319 164
Persistent depressive disorder (dysthymia) 65 41
Anxious mood 46 15
Bipolar disorder 36 23
Fatigue 30 15

Show all 96 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 52
Moderate 69
Mild 105
None 171

Commonly reported side effects and conditions associated with Wellbutrin XL

Side effect Patients
Anxious mood 17
Dry mouth 17
Difficulty staying asleep 13
Insomnia 12
Nausea 10
Sweating increased 9

Show all 132 reported side effects

Dosages

Based on patients currently taking Wellbutrin XL

Dosage Patients
300 mg daily 51
150 mg daily 32
300 mg/24 hours daily 29
150 mg/24 hours daily 15
450 mg daily 9
2 x 150 mg/24 hours daily 7
150 mg twice daily 3
200 mg twice daily 3
200 mg daily 2
400 mg daily 2

See all 19 dosages

Why patients stopped taking Wellbutrin XL

Multiple reasons could be selected

Reason Patients
Did not seem to work 110
Side effects too severe 100
Doctor's advice 93
Other 64
Expense 22
Course of treatment ended 14
Personal research 13
Change in health plan coverage 10
See all 300 patients who've stopped taking Wellbutrin XL

Duration

Currently taking Wellbutrin XL

Duration Patients
Less than 1 month 1
1 - 6 months 13
6 months - 1 year 16
1 - 2 years 20
2 - 5 years 33
5 - 10 years 39
10 years or more 41

Stopped taking Wellbutrin XL

Duration Patients
Less than 1 month 35
1 - 6 months 94
6 months - 1 year 32
1 - 2 years 44
2 - 5 years 55
5 - 10 years 28
10 years or more 13
Adherence
Adherence Evaluations
Always 319
Usually 58
Sometimes 8
Never taken as prescribed 12
Burden
Burden Evaluations
Very hard to take 13
Somewhat hard to take 25
A little hard to take 59
Not at all hard to take 300
Cost per month
Cost per month Evaluations
$200+ 4
$100-199 9
$50-99 17
$25-49 37
< $25 168
Not specified 162

What people switch to and from

Patients started taking Wellbutrin XL after stopping:

Treatment Patients
Sertraline (Zoloft) 15
Citalopram (Celexa) 12
Duloxetine (Cymbalta) 11
Venlafaxine (Effexor XR) 9
Bupropion (Wellbutrin XL) 6

Show all 22 treatments patients report switching from

Patients stopped taking Wellbutrin XL and switched to:

Treatment Patients
Duloxetine (Cymbalta) 8
Sertraline (Zoloft) 8
Venlafaxine (Effexor XR) 6
Lamotrigine (Lamictal) 5
Citalopram (Celexa) 4

Show all 24 treatments patients report switching to

Last updated:

39 patient evaluations for Wellbutrin XL

Apr 11, 2018 (Started May 15, 2017)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Cost: $200+ monthly

  • 0 helpful marks

Nov 1, 2016 (Started Aug 19, 2016)

  • Effectiveness
    None (for persistent depressive disorder (dysthymia))
  • Side effects
    Severe (serotonin syndrome, night sweats, unrefreshing or poor sleep, constipation, shakiness, hot flashes, brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily

  • 0 helpful marks

Aug 31, 2016 (Started Sep 10, 1997)

  • Effectiveness
    None (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Oct 23, 2015 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Jun 1, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Been back on Wellbutrin 450mg/day for a couple of ears now and, with the addition of 20mg/day of Viibryd I've been very stable.
Cost: < $25 monthly

Mar 11, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: $25-49 monthly

Aug 27, 2008 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Like any antidepressant, you (doctor & patient) have to determine what works for you. I was on various doses of Prozac for several years, but its effect eventually wore off. My psychopharmacologist switched me to Wellbutrin in 1997 and I've been on various doses of it since. Wellbutrin works on the dopamine system in the brain, so I'm curious how it relates to PD (if it does at all).
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 39 patient evaluations for Wellbutrin XL