What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Bupropion XL Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 2,301 1,296
Depressed mood 1,619 804
Persistent depressive disorder (dysthymia) 401 330
Mild depression 155 68
Anxious mood 121 67
Bipolar disorder 112 94

Show all 193 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 273
Moderate 379
Mild 616
None 1,145

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 107
Anxious mood 70
Weight gain 58
Insomnia 53
Headaches 48
Constipation 43

Show all 440 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
300 mg daily 184
150 mg daily 147
100 mg daily 69
300 mg/24 hours daily 68
450 mg daily 56
75 mg daily 50
150 mg twice daily 37
200 mg daily 28
100 mg twice daily 27
150 mg/24 hours daily 26

See all 65 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 660
Side effects too severe 556
Doctor's advice 428
Other 279
Course of treatment ended 92
Expense 84
Personal research 72
Change in health plan coverage 44
See all 1612 patients who've stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 8
1 - 6 months 35
6 months - 1 year 84
1 - 2 years 119
2 - 5 years 219
5 - 10 years 196
10 years or more 173

Stopped taking Bupropion

Duration Patients
Less than 1 month 357
1 - 6 months 357
6 months - 1 year 235
1 - 2 years 229
2 - 5 years 283
5 - 10 years 127
10 years or more 63
Adherence
Adherence Evaluations
Always 1894
Usually 355
Sometimes 51
Never taken as prescribed 113
Burden
Burden Evaluations
Very hard to take 82
Somewhat hard to take 146
A little hard to take 341
Not at all hard to take 1844
Cost per month
Cost per month Evaluations
$200+ 15
$100-199 27
$50-99 86
$25-49 175
< $25 1162
Not specified 948

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 94
Fluoxetine (Prozac) 91
Venlafaxine (Effexor XR) 73
Citalopram (Celexa) 52
Duloxetine (Cymbalta) 48

Show all 56 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 52
Sertraline (Zoloft) 49
Venlafaxine (Effexor XR) 36
Citalopram (Celexa) 31
Fluoxetine (Prozac) 31

Show all 49 treatments patients report switching to

Last updated:

188 patient evaluations for Bupropion

Nov 24, 2012 (Started Jan 15, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg/24 hours Daily
Advice & Tips: Added this to Lexapro after reading about the STAR D trials. Lexapro was a miracle compared to my untreated MDD but did not give me complete relief. I had previously tried this drug before alone for MDD but stopped due to nausea and vomiting. Tried it as an add on and it again made me sick. However, I had had more unpleasant med experiences since the last time I had tried it, so I kept taking it regardless. The vomiting and nausea side effects went away after about 10 days. I think it is great with Lexapro since the two drugs side effects seem to cancel each other out. Lexapro made me want to sleep 10 hours a night. Wellbutrin wants to give me insomia. Together = 7 hours of sleep a night. Lexapro wants to give me constipation while Bup wants to give you the runs. Together = totally normal. Lex wants me to eat everything and bup wants me to never eat. Together = normal weight.
Cost: < $25 monthly

  • 0 helpful marks

Nov 18, 2012 (Started Jul 23, 2012)

  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Sep 14, 2012 (Started Feb 01, 2011)

  • Effectiveness
    None (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Very hard to take
Dosage: 150 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 188 patient evaluations for Bupropion