What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Wellbutrin SR Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major Depressive Disorder 1,735 993
Depressed mood 1,504 712
Persistent depressive disorder (dysthymia) 328 278
Mild Depression 138 55
Anxious mood 114 54
Bipolar Disorder 100 84

Show all 204 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 225
Moderate 322
Mild 524
None 910

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 89
Anxious mood 53
Insomnia 45
Weight gain 45
Constipation 40
Headaches 39

Show all 401 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
150 mg daily 116
300 mg daily 110
300 mg/24 hours daily 74
100 mg daily 71
450 mg daily 39
75 mg daily 38
100 mg twice daily 33
150 mg/24 hours daily 31
200 mg daily 21
150 mg twice daily 18

See all 65 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 546
Side effects too severe 466
Doctor's advice 358
Other 245
Course of treatment ended 78
Expense 78
Personal research 66
Change in health plan coverage 36
See all 1353 patients who’ve stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 7
1 - 6 months 40
6 months - 1 year 62
1 - 2 years 106
2 - 5 years 162
5 - 10 years 172
10 years or more 123

Stopped taking Bupropion

Duration Patients
Less than 1 month 266
1 - 6 months 326
6 months - 1 year 213
1 - 2 years 199
2 - 5 years 236
5 - 10 years 107
10 years or more 46
Adherence
Adherence Evaluations
Always 1549
Usually 312
Sometimes 44
Never taken as prescribed 76
Burden
Burden Evaluations
Very hard to take 68
Somewhat hard to take 121
A little hard to take 301
Not at all hard to take 1491
Cost per month
Cost per month Evaluations
$200+ 10
$100-199 25
$50-99 77
$25-49 154
< $25 966
Not specified 749

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 60
Fluoxetine (Prozac) 50
Venlafaxine (Effexor XR) 47
Duloxetine (Cymbalta) 37
Citalopram (Celexa) 26

Show all 38 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 36
Sertraline (Zoloft) 29
Venlafaxine (Effexor XR) 19
Citalopram (Celexa) 16
Escitalopram (Lexapro) 16

Show all 39 treatments patients report switching to

Last updated:

185 patient evaluations for Bupropion

1,509 members have decided to share their profiles only with other members of PatientsLikeMe.

mountainlion
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mountainlion
Gender: F
Data Quality: 1 star
Depression: 0
Mania: 1
Emotional: 0
Anxiety: 1
Compulsion: 0
External Stress: Moderate
41 F
Function: Moderate
Distress: Low
I am: g
I have:
Bipolar Disorder

See mountainlion's full Bupropion history

Apr 27, 2012 (Started Aug 01, 2006)

  • Effectiveness
    Moderate (for Fatigue)
  • Side effects
    Mild (Weight loss)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Cost: < $25 monthly

  • 0 helpful marks
jiwhite
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jiwhite
Gender: F
Data Quality: 1 star
Depression: 0
Mania: 0
Emotional: 0
Anxiety: 1
Compulsion: 1
External Stress: Severe
48 F
Function: High
Distress: Low
I am: g
I have:
GAD

See jiwhite's full Bupropion history

Apr 8, 2012 (Started Jul 01, 2007)

  • Effectiveness
    Moderate (for Generalized Anxiety Disorder)
  • Effectiveness
    Major (for Major Depressive Disorder)
  • Side effects
    Mild (Morning nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 150 mg Daily
Advice & Tips: I use a pill organizer to keep track of whether or not I have taken my pills for the day and take them at the same time every day. I take pills at night when possible to minimize nausea.
Cost: $100-199 monthly

  • 0 helpful marks
lilybet
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lilybet
Gender: F
Data Quality: 1 star
Depression: 1
Mania: 0
Emotional: 1
Anxiety: 1
Compulsion: 0
External Stress: Overwhelming
57 F
Function: Moderate
Distress: Low
I am: n
I have:
Major Depressive Disorder

See lilybet's full Bupropion history

Feb 23, 2012 (Started Mar 24, 2006)

  • Effectiveness
    Slight (for Reactive Depression)
  • Effectiveness
    Slight (for Major Depressive Disorder)
  • Effectiveness
    Slight (for Treat my mood condition(s))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 400 mg Daily
Advice & Tips: I really can't tell if Wellbutrin is helping me or not. The last several years have been so difficult for me that I'm not sure anything can help except time (and good psychotherapy!)
Cost: < $25 monthly

Sep 15, 2011 (Started Mar 24, 2006)

  • Effectiveness
    None (for Treat my mood condition(s))
  • Effectiveness
    None (for Reactive Depression)
  • Effectiveness
    None (for Major Depressive Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 400 mg Daily
Advice & Tips: I've been taking Wellbutrin since 2006. Since I've had several severe depression episodes since then, I really don't think it is helping at all.
Cost: < $25 monthly

Sep 9, 2008 (Started Mar 24, 2006)

  • Effectiveness
    Can’t tell (for Treat my mood condition(s))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: Well, I'm still depressed somewhat. But the reasons for it are more than biochemical, so I'm taking the med. Who knows what kind of shape I'd be in without it? (previously, bad!)
Cost: < $25 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 185 patient evaluations for Bupropion