What is Dextromethorphan-Quinidine?

Category: Prescription Drugs

Most popular types: Nuedexta 07-AVR-123 OLE

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A dextromethorphan-quinidine combination was studied for its effect on inappropriate laughing and crying episodes experienced by some patients with brain injury or brain degeneration due to certain diseases. The incongruous laughing and crying episodes are due to pseudobulbar affect.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Emotional lability 110 104
Amyotrophic lateral sclerosis 78 69
Doctor recommendation 16 22
Pseudobulbar affect 12 9
Swallowing difficulty (dysphagia) 5 7

Show all 32 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 7
Moderate 16
Mild 18
None 125

Commonly reported side effects and conditions associated with Dextromethorphan-Quinidine

Side effect Patients
Diarrhea 4
Dry mouth 4
Sleepiness 4
Dizziness 3
Nausea 3
Balance problems 2

Show all 30 reported side effects

Dosages

Based on patients currently taking Dextromethorphan-Quinidine

Dosage Patients
20-10 mg twice daily 42
20-10 mg daily 18
1 capsule(s) daily 4
20 mg twice daily 4
2 x 20-10 mg twice daily 3
1 capsule(s) twice daily 2
10 mg twice daily 2
20 mg daily 2
20-10 mg three times daily 2
1 mg twice daily 1

See all 14 dosages

Why patients stopped taking Dextromethorphan-Quinidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 11
Side effects too severe 8
Course of treatment ended 2
Expense 2
Other 2
Doctor's advice 1
See all 24 patients who've stopped taking Dextromethorphan-Quinidine

Duration

Currently taking Dextromethorphan-Quinidine

Duration Patients
1 - 6 months 13
6 months - 1 year 17
1 - 2 years 26
2 - 5 years 22
5 - 10 years 5

Stopped taking Dextromethorphan-Quinidine

Duration Patients
Less than 1 month 8
1 - 6 months 7
6 months - 1 year 4
1 - 2 years 2
2 - 5 years 3
Adherence
Adherence Evaluations
Always 146
Usually 15
Sometimes 4
Never taken as prescribed 1
Burden
Burden Evaluations
Very hard to take 0
Somewhat hard to take 7
A little hard to take 11
Not at all hard to take 148
Cost per month
Cost per month Evaluations
$200+ 17
$100-199 5
$50-99 18
$25-49 41
< $25 21
Not specified 64

What people switch to and from

Patients started taking Dextromethorphan-Quinidine after stopping:

Treatment Patients
Venlafaxine (Effexor XR) 2
Amitriptyline (Elavil) 1
Sertraline (Zoloft) 1

Patients stopped taking Dextromethorphan-Quinidine and switched to:

Treatment Patients
Alprazolam (Xanax) 1
Last updated:

12 patient evaluations for Dextromethorphan-Quinidine

Jul 3, 2017 (Started May 14, 2017)

  • Effectiveness
    Major (for amyotrophic lateral sclerosis)
  • Effectiveness
    Major (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20-10 mg Daily
Advice & Tips: This has been a miracle drug for myself as I no longer have the outburst of unexpected crying and or laughter.
Cost: $200+ monthly

  • 0 helpful marks

May 5, 2017 (Started Apr 15, 2017)

  • Effectiveness
    Major (for amyotrophic lateral sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: This drug is a must for anyone who suffers from emotional liability.(Unexpected for long periods of time laughing & crying)
Cost: $200+ monthly

  • 0 helpful marks

Feb 20, 2017 (Started Apr 20, 2012)

  • Effectiveness
    Moderate (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 20 mg Twice daily
Cost: $200+ monthly

Jul 27, 2015 (Started Apr 20, 2012)

  • Effectiveness
    Moderate (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Twice daily

Jan 31, 2013 (Started Apr 20, 2012)

  • Effectiveness
    Major (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Twice daily
Advice & Tips: Helps with swallowing Side effects when I went off one time. I suggest weaning off if stopping

  • 0 helpful marks
Last updated:
Showing 3 of 12 patient evaluations for Dextromethorphan-Quinidine