What is Dextromethorphan-Quinidine?

Category: Prescription Drugs

Most popular types: Nuedexta 07-AVR-123 OLE

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A dextromethorphan-quinidine combination was studied for its effect on inappropriate laughing and crying episodes experienced by some patients with brain injury or brain degeneration due to certain diseases. The incongruous laughing and crying episodes are due to pseudobulbar affect.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Emotional lability 103 97
ALS (Amyotrophic Lateral Sclerosis) 73 64
Doctor recommendation 16 21
Pseudobulbar affect 10 5
Swallowing difficulty (dysphagia) 5 7
Speech problems 4 5

Show all 35 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 7
Moderate 15
Mild 16
None 119

Commonly reported side effects and conditions associated with Dextromethorphan-Quinidine

Side effect Patients
Diarrhea 4
Dry mouth 4
Sleepiness 4
Dizziness 3
Nausea 3
Flatulence 2

Show all 29 reported side effects

Dosages

Based on patients currently taking Dextromethorphan-Quinidine

Dosage Patients
20-10 mg twice daily 30
20-10 mg daily 23
20 mg twice daily 5
1 capsule(s) daily 3
10 mg twice daily 3
1 capsule(s) twice daily 2
20 mg daily 2
20-10 mg three times daily 2
1 mg twice daily 1
2 capsule(s) twice daily 1

See all 14 dosages

Why patients stopped taking Dextromethorphan-Quinidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 12
Side effects too severe 8
Course of treatment ended 2
Expense 2
Other 2
Change in health plan coverage 1
Doctor's advice 1
See all 25 patients who’ve stopped taking Dextromethorphan-Quinidine

Duration

Currently taking Dextromethorphan-Quinidine

Duration Patients
Less than 1 month 3
1 - 6 months 16
6 months - 1 year 13
1 - 2 years 26
2 - 5 years 15
5 - 10 years 2
10 years or more 1

Stopped taking Dextromethorphan-Quinidine

Duration Patients
Less than 1 month 8
1 - 6 months 7
6 months - 1 year 6
1 - 2 years 1
2 - 5 years 3
Adherence
Adherence Evaluations
Always 137
Usually 15
Sometimes 4
Never taken as prescribed 1
Burden
Burden Evaluations
Very hard to take 0
Somewhat hard to take 5
A little hard to take 11
Not at all hard to take 141
Cost per month
Cost per month Evaluations
$200+ 15
$100-199 3
$50-99 17
$25-49 37
< $25 21
Not specified 64

What people switch to and from

Patients started taking Dextromethorphan-Quinidine after stopping:

Treatment Patients
Venlafaxine (Effexor XR) 2
Amitriptyline (Elavil) 1
Fluoxetine (Prozac) 1
Sertraline (Zoloft) 1

Patients stopped taking Dextromethorphan-Quinidine and switched to:

Treatment Patients
Alprazolam (Xanax) 1
Fluoxetine (Prozac) 1
Last updated:

11 patient evaluations for Dextromethorphan-Quinidine

99 members have decided to share their profiles only with other members of PatientsLikeMe.

ltbeauti
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ltbeauti
Sex: F
Data Quality: 2 stars
Bulbar: moderate
Arms: moderate
Chest: mild
Legs: moderate
I am: g
I have:
ALS

See ltbeauti's full Dextromethorphan-Quinidine history

Feb 20, 2017 (Started Apr 20, 2012)

  • Effectiveness
    Moderate (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 20 mg Twice daily
Cost: $200+ monthly

Jul 27, 2015 (Started Apr 20, 2012)

  • Effectiveness
    Moderate (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Twice daily

Jan 31, 2013 (Started Apr 20, 2012)

  • Effectiveness
    Major (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Twice daily
Advice & Tips: Helps with swallowing Side effects when I went off one time. I suggest weaning off if stopping

  • 0 helpful marks
Navy Nurse
3557 thumb
Navy Nurse
Sex: F
Data Quality: 2 stars
Bulbar: moderate
Arms: severe
Chest: none
Legs: moderate
I have:
ALS

See Navy Nurse's full Dextromethorphan-Quinidine history

Aug 30, 2016 (Started May 03, 2006)

  • Effectiveness
    Major (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: Twice daily
Cost: < $25 monthly

Aug 13, 2011 (Started May 03, 2006)

  • Effectiveness
    Major (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: Twice daily
Cost: < $25 monthly

Nov 17, 2010 (Started May 03, 2006)

  • Effectiveness
    Major (for Emotional lability)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: Twice daily
Cost: $50-99 monthly

  • 1 helpful mark
newtons1971
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newtons1971
Sex: M
Data Quality: 3 stars
Bulbar: none
Arms: mild
Chest: none
Legs: mild
I am: vg
I have:
ALS

See newtons1971's full Dextromethorphan-Quinidine history

Jun 30, 2016 (Started Jul 01, 2015)

  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20-10 mg Daily
Advice & Tips: Did not see any significant change.

Jun 30, 2015 (Started Jul 01, 2015)

  • Effectiveness
    Can’t tell (for ALS (Amyotrophic Lateral Sclerosis))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20-10 mg Daily
Advice & Tips: Did not see any significant change.

  • 0 helpful marks
Last updated:
Showing 3 of 11 patient evaluations for Dextromethorphan-Quinidine