What is Dextromethorphan-Quinidine?

Category: Prescription Drugs

Most popular types: Nuedexta 07-AVR-123 OLE

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A dextromethorphan-quinidine combination was studied for its effect on inappropriate laughing and crying episodes experienced by some patients with brain injury or brain degeneration due to certain diseases. The incongruous laughing and crying episodes are due to pseudobulbar affect.

Reported purpose & perceived effectiveness

Purpose
Patients
Patients with evaluations
Perceived effectiveness

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 3
Moderate 9
Mild 10
None 41

Commonly reported side effects and conditions associated with Dextromethorphan-Quinidine

Side effect Patients
Diarrhea 4
Sleepiness 3
Dizziness 2
Dry mouth 2
Gas 2
Bladder problems 1

Show all 24 reported side effects

Dosages

Based on patients currently taking Dextromethorphan-Quinidine

Dosage Patients
10 mg twice daily 8
20 mg twice daily 6
1 capsule(s) daily 5
20-10 mg twice daily 5
2 capsule(s) daily 2
2 mg daily 2
2 capsule(s) twice daily 2
20-10 mg daily 2
20 mg daily 2
20-10 mg three times daily 2

See all 16 dosages

Why patients stopped taking Dextromethorphan-Quinidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 11
Side effects too severe 6
Course of treatment ended 3
Expense 2
Change in health plan coverage 1
Doctor's advice 1
Other 1
See all 22 patients who’ve stopped taking Dextromethorphan-Quinidine

Duration

Currently taking Dextromethorphan-Quinidine

Duration Patients
0-1 month 1
1-3 months 1
3-6 months 6
6 months-1 year 9
1-2 years 13
2 years or more 12

Stopped taking Dextromethorphan-Quinidine

Duration Patients
0-1 month 7
1-3 months 5
3-6 months 1
6 months-1 year 4
1-2 years 1
2 years or more 4

Adherence


Always
Patients
53
84%
Usually
Patients
6
10%
Sometimes
Patients
3
5%
Never taken as prescribed
Patients
1
2%

Burden


Very hard to take
Patients
0
0%
Somewhat hard to take
Patients
2
3%
A little hard to take
Patients
8
13%
Not at all hard to take
Patients
53
84%

Cost per month


Cost per month
$200+
Patients
4
6%
Cost per month
$100-199
Patients
1
2%
Cost per month
$50-99
Patients
5
8%
Cost per month
$25-49
Patients
12
19%
Cost per month
< $25
Patients
12
19%
Cost per month
Not specified
Patients
29
46%

What people switch to and from

Patients started taking Dextromethorphan-Quinidine after stopping:

Treatment Patients
Venlafaxine (Effexor XR) 2
Amitriptyline (Elavil) 1
Fluoxetine (Prozac) 1

Patients stopped taking Dextromethorphan-Quinidine and switched to:

Treatment Patients
Fluoxetine (Prozac) 1
Last updated:

10 patient evaluations for Dextromethorphan-Quinidine

63 members have decided to share their profiles only with other members of PatientsLikeMe.

Bill01
13018 thumb
Bill01
Sex: M
Data Quality: 3 stars
Bulbar: moderate
Arms: mild
Chest: moderate
Legs: moderate
I am: g
I have:
ALS

See Bill01's full Dextromethorphan-Quinidine history

Oct 26, 2015 (Started Mar 15, 2014)

  • Effectiveness
    Major (for ALS (Amyotrophic Lateral Sclerosis))
  • side effects
    Moderate (Pseudobulbar affect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Three times daily
Advice & Tips: It has improved my speech and swallowing.
Cost: $25-49 monthly

  • 0 helpful marks
ltbeauti
1705 thumb
ltbeauti
Sex: F
Data Quality: 3 stars
Bulbar: moderate
Arms: moderate
Chest: mild
Legs: moderate
I am: g
I have:
ALS

See ltbeauti's full Dextromethorphan-Quinidine history

Jul 27, 2015 (Started Apr 20, 2012)

  • Effectiveness
    Moderate (for Emotional lability)
  • side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Twice daily

Jan 31, 2013 (Started Apr 20, 2012)

  • Effectiveness
    Major (for Emotional lability)
  • side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Twice daily
Advice & Tips: Helps with swallowing Side effects when I went off one time. I suggest weaning off if stopping

  • 0 helpful marks
Cruiser
Portrait default thumb
Cruiser
Sex: F
Data Quality: 0 stars
Bulbar: mild
Arms: none
Chest: none
Legs: moderate
I am: vg
I have:
PLS

See Cruiser's full Dextromethorphan-Quinidine history

Apr 27, 2015 (Started Oct 10, 2008)

  • Effectiveness
    Slight (for emotions, to stop uncontrollable laughing and crying)
  • side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Advice & Tips: When I first took it it was great. Now some of the crying is coming back. I wish I could find something else
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 10 patient evaluations for Dextromethorphan-Quinidine