What is Estradiol?

Category: Prescription Drugs

Most popular types: Estrace Vivelle-Dot Patch Climara HRT patch Show all

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See also: Bi-Est Estradiol-norethindrone Estrogen patch

Estradiol, an estrogen derivative is used to treat menopausal symptoms, vaginal atrophy, hypoestrogenism; palliation of prostate and breast cancer; prevention of osteoporosis; abnormal uterine bleeding; and postmenopausal urinary symptoms (urgency, dysuria).

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Hysterectomy 96 27
Menopause 73 22
General health 34 10
Hormone replacement 27 14
Hot flashes 18 6
Support hormone balance 11 2

Show all 45 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 6
Moderate 11
Mild 24
None 79

Commonly reported side effects and conditions associated with Estradiol

Side effect Patients
Fatigue 2
Headaches 2
Hot flashes 2
Migraine headaches 2
Nausea 2
Weight gain 2

Show all 28 reported side effects

Dosages

Based on patients currently taking Estradiol

Dosage Patients
2 mg daily 14
1 mg daily 13
0.5 mg daily 10
1 other every 3 months 2
1.5 mg daily 2
6 mg daily 2
0.025 mg/24 hours weekly weekly 1
0.0,375 mcg weekly 1
0.05 mg/24 hours twice weekly weekly 1
0.05 mg/24 hr weekly 1

See all 30 dosages

Why patients stopped taking Estradiol

Multiple reasons could be selected

Reason Patients
Doctor's advice 21
Other 17
Did not seem to work 7
Course of treatment ended 6
Expense 6
Personal research 5
Side effects too severe 5
Change in health plan coverage 2
See all 60 patients who’ve stopped taking Estradiol

Duration

Currently taking Estradiol

Duration Patients
Less than 1 month 1
1 - 6 months 5
6 months - 1 year 6
1 - 2 years 8
2 - 5 years 10
5 - 10 years 11
10 years or more 26

Stopped taking Estradiol

Duration Patients
1 - 6 months 12
6 months - 1 year 8
1 - 2 years 10
2 - 5 years 18
5 - 10 years 7
10 years or more 7
Adherence
Adherence Evaluations
Always 80
Usually 32
Sometimes 1
Never taken as prescribed 7
Burden
Burden Evaluations
Very hard to take 3
Somewhat hard to take 11
A little hard to take 16
Not at all hard to take 90
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 1
$50-99 9
$25-49 11
< $25 55
Not specified 44

What people switch to and from

Patients started taking Estradiol after stopping:

Treatment Patients
Estrogen derivative (Premarin) 7
Estradiol (Estrace) 2
Estradiol Patch (Estrogen patch) 2
Esterified estrogen-methyltestosterone (Estratest) 1
Estradiol topical (Estrace Vaginal Cream) 1

Show all 7 treatments patients report switching from

Patients stopped taking Estradiol and switched to:

Treatment Patients
Estradiol (Estrace) 1
Estradiol Patch (Estrogen patch) 1
Estrogen derivative (Premarin) 1
ethinyl estradiol-norgestimate (Ortho Tri-Cyclen) 1
Progesterone (Prometrium) 1
Last updated:

14 patient evaluations for Estradiol

88 members have decided to share their profiles only with other members of PatientsLikeMe.

ChloeMS
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ChloeMS
Data Quality: 3 stars
Pain: Most
Fatigue: All
Sleep: All
Stiffness: Most
function: None
external_stress: All
Stickman: all
Description:61y
CFS:19y Dx
FM:19y Dx
I am: b
I have:
ME/CFS

See ChloeMS's full Estradiol history

Sep 23, 2014 (Started Jan 01, 2009)

  • Effectiveness
    Can’t tell (for Gender Dysphoria)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 6 mg Daily
Advice & Tips: These pills are way too tiny. I am finding them on the floor from when I try to get one and more fall into my hand, then one slips between my fingers as I try to put them back.

Sep 11, 2014 (Started Jan 01, 2009)

  • Effectiveness
    Can’t tell (for Gender Dysphoria)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 6 mg Daily
Advice & Tips: This is only 3xday med I take and I frequently miss the middle dose

Aug 27, 2014 (Started Jan 01, 2009)

  • Effectiveness
    Can’t tell (for Gender Dysphoria)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 0.06 g Daily
Advice & Tips: This is only 3xday med I take and I frequently miss the middle dose
Cost: $50-99 monthly

Nov 14, 2013 (Started Jan 01, 2009)

  • Effectiveness
    Major (for Gender Dysphoria)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 0.06 g Daily
Cost: $50-99 monthly

Nov 9, 2013 (Started Jan 01, 2009)

  • Effectiveness
    Major (for Gender Dysphoria)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Very hard to take
Dosage: 0.06 g Daily
Cost: $50-99 monthly

Jul 16, 2013 (Started Jan 01, 2009)

  • Effectiveness
    Major (for Gender Dysphoria)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 0.06 g Daily
Cost: $25-49 monthly

  • 0 helpful marks
#1ladyjane
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#1ladyjane
Gender: F
Data Quality: 2 stars
Pain: Some
Fatigue: Most
Sleep: Some
Stiffness: All
function: None
external_stress: Little
Stickman: most
Description:F56y
CFS:?y
FM:20y Dx
I am: b
I have:
Fibromyalgia

See #1ladyjane's full Estradiol history

Jan 15, 2012 (Started Apr 01, 2007)

  • Effectiveness
    Slight (for Menopause)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 mg Daily
Advice & Tips: I found that the side effects were undesirable (hair falling out). Adverse effects, which may occur as a result of use of estradiol and have been associated with estrogen and/or progestin therapy, include changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia, endometrial cancer, nipple discharge, galactorrhea, fibrocystic breast changes and breast cancer. Cardiovascular effects include chest pain, deep and superficial venous thrombosis, pulmonary embolism, thrombophlebitis, myocardial infarction, stroke, and increased blood pressure. Gastrointestinal effects include nausea and vomiting, abdominal cramps, bloating, diarrhea, dyspepsia, dysuria, gastritis, cholestatic jaundice, increased incidence of gallbladder disease, pancreatitis, or enlargement of hepatic hemangiomas. Skin adverse effects include chloasma or melasma that may continue despite discontinuation of the drug. Other effects on the skin include erythema multiforme, erythema nodosum, otitis media, hemorrhagic eruption, loss of scalp hair, hirsutism, pruritus, or rash. Adverse effects on the eyes include retinal vascular thrombosis, steepening of corneal curvature or intolerance to contact lenses. Adverse central nervous system effects include headache, migraine, dizziness, mental depression, chorea, nervousness/anxiety, mood disturbances, irritability, and worsening of epilepsy. Other adverse effects include changes in weight, reduced carbohydrate tolerance, worsening of porphyria, edema, arthralgias, bronchitis, leg cramps, hemorrhoids, changes in libido, urticaria, angioedema, anaphylactic reactions, syncope, toothache, tooth disorder, urinary incontinence, hypocalcemia, exacerbation of asthma, and increased triglycerides.[21][22] Estrogen combined with medroxyprogesterone is associated with an increased risk of dementia. It is not known whether estradiol taken alone is associated with an increased risk of dementia. Estrogens should only be used for the shortest possible time and at the lowest effective dose due to these risks. Attempts to gradually reduce the medication via a dose taper should be made every three to six months.[2

  • 0 helpful marks
badger71
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badger71
Gender: F
Data Quality: 1 star
Pain: All
Fatigue: Most
Sleep: Most
Stiffness: All
function: Some
external_stress: All
Stickman: all
Description:F45y
FM:7y Dx
CFS:?y
I am: n
I have:
Fibromyalgia

See badger71's full Estradiol history

Oct 9, 2010 (Started Sep 20, 2010)

  • Effectiveness
    Can’t tell (for Hysterectomy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 14 patient evaluations for Estradiol