What is Acetaminophen-Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Tylenol PM Pain Reliever PM Tylenol Extra Strength PM Show all

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Acetaminophen and diphenhydramine are combined in a variety of over the counter preparations. It is used to aid in the relief of insomnia accompanied by minor pain.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 49 24
Pain 49 12
Sleeplessness 26 17
Headaches 9 3
Difficulty staying asleep 6 0

Show all 30 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 2
Moderate 5
Mild 13
None 41

Commonly reported side effects and conditions associated with Acetaminophen-Diphenhydramine

Side effect Patients
Groggy in morning 5
Upset stomach 2
Breakthrough pain 1
Daytime sleepiness 1
Dizziness 1
Liver impairment 1

Show all 10 reported side effects

Dosages

Based on patients currently taking Acetaminophen-Diphenhydramine

Dosage Patients
2 x 1,000 mg-50 mg/30 mL daily 3
500mg as needed 3
2 x 500-25 mg daily 2
5 mg twice daily 1
500-25 mg daily 1
500 mg-25 mg daily 1
500 mg daily 1
2 x 1,000 mg-50 mg/30 mL three times daily 1
1,000 mg-50 mg/30 mL as needed 1
1,000 mg as needed 1

See all 16 dosages

Why patients stopped taking Acetaminophen-Diphenhydramine

Multiple reasons could be selected

Reason Patients
Other 17
Did not seem to work 12
Doctor's advice 7
Side effects too severe 7
Course of treatment ended 3
Expense 2
See all 40 patients who've stopped taking Acetaminophen-Diphenhydramine

Duration

Currently taking Acetaminophen-Diphenhydramine

Duration Patients
Less than 1 month 1
6 months - 1 year 3
1 - 2 years 2
2 - 5 years 3
5 - 10 years 6
10 years or more 9

Stopped taking Acetaminophen-Diphenhydramine

Duration Patients
Less than 1 month 6
1 - 6 months 6
6 months - 1 year 5
1 - 2 years 5
2 - 5 years 10
5 - 10 years 7
10 years or more 1
Adherence
Adherence Evaluations
Always 25
Usually 19
Sometimes 12
Never taken as prescribed 5
Burden
Burden Evaluations
Very hard to take 4
Somewhat hard to take 1
A little hard to take 7
Not at all hard to take 49
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 0
$50-99 0
$25-49 3
< $25 39
Not specified 19
Last updated:

11 patient evaluations for Acetaminophen-Diphenhydramine

Jul 1, 2015 (Started Jul 10, 2009)

  • Effectiveness
    Can't tell (for pain/sleeplessness)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks

Jul 15, 2011 (Started Jun 15, 2004)

  • Effectiveness
    Major (for General health)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 500 mg Daily
Advice & Tips: helps me get to sleep and sleep through the night

May 15, 2010 (Started Jun 15, 2004)

  • Effectiveness
    Major (for General health)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 500 mg Daily

  • 0 helpful marks

Mar 13, 2011 (Started Jan 01, 2009)

  • Effectiveness
    Major (for insomnia)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 2 x 1000 mg-50 mg/30 mL Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 11 patient evaluations for Acetaminophen-Diphenhydramine