What is melorheostosis?

Melorheostosis is a rare developmental bone disorder thought to be caused by a defect in the LEMD3 gene. It may be asymptomatic, but pain, stiffness with limitation of motion, leg-length discrepancy and limb deformity may occur.

How do members experience melorheostosis?

Top 5 symptoms reported by people with melorheostosis*

*Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.

Top treatments taken by people for melorheostosis*

Who has melorheostosis on PatientsLikeMe?


Age Proportion # of patients
<20 0
20s 2
30s 5
40s 2
50s 3
60s 1
70+ 1

Distribution of sex


Sex Proportion # of patients
Male 6
Female 8