Multiple system atrophy

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What is multiple system atrophy?

Multiple system atrophy (MSA) is a degenerative neurological disorder. MSA is associated with the degeneration of nerve cells in specific areas of the brain. This cell degeneration causes problems with movement, balance and autonomic functions of the body such as bladder control.

Common symptoms reported by people with multiple system atrophy

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
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Treatments taken by people with multiple system atrophy

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Sinemet)
Type
Prescription Drug
How many have tried
17
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
9
Treatment name(s)

(Florinef)
Type
Prescription Drug
How many have tried
9
Tried for
multiple system atrophy (9)
Treatment name(s)

(Symmetrel)
Type
Prescription Drug
How many have tried
4
Treatment name(s)

(Rytary XR)
Type
Prescription Drug
How many have tried
4
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
3
Tried for
Depressed mood (2) Pain (1)
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
3
Tried for
Depressed mood (2) Anxious mood (1)
Treatment name(s)

(Xanax)
Type
Prescription Drug
How many have tried
2
Tried for
Anxious mood (2)
Treatment name(s)

(Elavil)
Type
Prescription Drug
How many have tried
2
Tried for
Insomnia (2)
Treatment name(s)

(Nuvigil)
Type
Prescription Drug
How many have tried
2

Data from patients with multiple system atrophy, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with multiple system atrophy

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Sinemet)
Perceived effectiveness
for multiple system atrophy (8 evaluations)
Side effects
Allergic reaction Constipation 5 more
Total evaluations
9
Treatment name(s)

(Klonopin)
Perceived effectiveness
for multiple system atrophy (1 evaluation)
Side effects
Drowsy in a.m. Morning sleepiness
Total evaluations
3
Treatment name(s)

(Florinef)
Perceived effectiveness
for multiple system atrophy (4 evaluations)
Side effects
Fluid retention weight gain
Total evaluations
4
Tried for
multiple system atrophy (9)
Treatment name(s)

(Symmetrel)
Perceived effectiveness
for Fatigue (2 evaluations)
Side effects
Constipation Dizziness and feeling faint
Total evaluations
3
Treatment name(s)

(Rytary XR)
Perceived effectiveness
for multiple system atrophy (2 evaluations)
Side effects
Bruxism (teeth grinding) Unresponsiveness
Total evaluations
2
Treatment name(s)

(Cymbalta)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
Depressed mood (2) Pain (1)
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Depressed mood (1 evaluation)
Side effects
Excessive daytime sleepiness (somnolence)
Total evaluations
2
Tried for
Depressed mood (2) Anxious mood (1)
Treatment name(s)

(Xanax)
Perceived effectiveness
for Anxious mood (2 evaluations)
Side effects
Drowsiness
Total evaluations
2
Tried for
Anxious mood (2)
Treatment name(s)

(Elavil)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
Insomnia (2)
Treatment name(s)

(Nuvigil)
Perceived effectiveness
for Excessive daytime sleepiness (somnolence) (2 evaluations)
Side effects
Elevated blood pressure Nausea
Total evaluations
3
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with multiple system atrophy, who reported starting treatments within the last 5 years.
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Who has multiple system atrophy on PatientsLikeMe?


Age
Age Proportion # of patients
<20 0
20s 10
30s 26
40s 49
50s 165
60s 256
70+ 166
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8
20-29 years 14
30-39 years 31
40-49 years 90
50-59 years 158
60-69 years 73
70+ years 13

Sex

Distribution of sex

52% Female
48% Male

Types
Condition Types Proportion # of patients
Multiple system atrophy (MSA) 299
Olivopontocerebellar atrophy (OPCA/MSA-c) 106
Shy-Drager syndrome (MSA-a) 61
Striatonigral degeneration (MSA-p) 82
Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 400
Not Diagnosed 63

These charts show data from MSA patients who have completed their condition history
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