Major Depressive Disorder

We’re all in this for good.

By sharing your stories and data, you will:
  • help each other live better and uncover the best ways to manage your health today
  • help researchers shorten the path to new treatments tomorrow

How much good can your data do? A whole lot, as co-founder Jamie Heywood explains in this video.

What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
793
Tried for
Major Depressive Disorder (751) Depressed mood (89)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
694
Tried for
Major Depressive Disorder (644) Depressed mood (124)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
618
Tried for
Major Depressive Disorder (510) Depressed mood (221)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
563
Tried for
Major Depressive Disorder (494) Depressed mood (165)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
554
Tried for
Major Depressive Disorder (550) Anxious mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
502
Tried for
Major Depressive Disorder (423) Depressed mood (168)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
382
Tried for
Major Depressive Disorder (348) Anxious mood (72)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
380
Tried for
Major Depressive Disorder (361) Depressed mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
296
Tried for
Anxious mood (291) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
222
Tried for
Insomnia (212) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (396 evaluations)
Side effects
Anxious mood Headaches 166 more
Total evaluations
456
Tried for
Major Depressive Disorder (751) Depressed mood (89)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (346 evaluations)
Side effects
Dry mouth Weight gain 144 more
Total evaluations
450
Tried for
Major Depressive Disorder (644) Depressed mood (124)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (287 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 157 more
Total evaluations
390
Tried for
Major Depressive Disorder (510) Depressed mood (221)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (297 evaluations)
Side effects
Dry mouth Nausea 157 more
Total evaluations
368
Tried for
Major Depressive Disorder (493) Depressed mood (165)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (251 evaluations)
Side effects
Anxious mood Depressed mood 65 more
Total evaluations
304
Tried for
Major Depressive Disorder (550) Anxious mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (232 evaluations)
Side effects
Suicidal thoughts or urges Weight gain 125 more
Total evaluations
297
Tried for
Major Depressive Disorder (423) Depressed mood (168)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (198 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 95 more
Total evaluations
237
Tried for
Major Depressive Disorder (348) Anxious mood (72)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (205 evaluations)
Side effects
Dry mouth Sleepiness 95 more
Total evaluations
239
Tried for
Major Depressive Disorder (361) Depressed mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (163 evaluations)
Side effects
Drowsiness Sleepiness 42 more
Total evaluations
180
Tried for
Anxious mood (291) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (107 evaluations)
Side effects
Dry mouth Grogginess 46 more
Total evaluations
116
Tried for
Insomnia (212) Major Depressive Disorder (23)
4 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 535
20s 4,198
30s 7,697
40s 10,497
50s 10,234
60s 4,763
70+ 735
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,609
20-29 years 2,570
30-39 years 1,769
40-49 years 1,067
50-59 years 342
60-69 years 59
70+ years 6

Sex

Distribution of sex

77% Female
23% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 16,534
Not Diagnosed 2,247

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: