Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
830
Tried for
major depressive disorder (791) Depressed mood (93)
7 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
666
Tried for
major depressive disorder (621) Depressed mood (123)
8 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
620
Tried for
major depressive disorder (519) Depressed mood (220)
7 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
592
Tried for
major depressive disorder (588) Anxious mood (10)
5 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
561
Tried for
major depressive disorder (495) Depressed mood (167)
8 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
527
Tried for
major depressive disorder (440) Depressed mood (182)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
407
Tried for
major depressive disorder (370) Anxious mood (74)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
351
Tried for
major depressive disorder (337) Depressed mood (55)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
284
Tried for
Anxious mood (278) Insomnia (13)
3 more
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
218
Tried for
Insomnia (208) major depressive disorder (19)
4 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (420 evaluations)
Side effects
Anxious mood Headaches 173 more
Total evaluations
482
Tried for
major depressive disorder (791) Depressed mood (93)
7 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (343 evaluations)
Side effects
Weight gain Dry mouth 140 more
Total evaluations
442
Tried for
major depressive disorder (621) Depressed mood (123)
8 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (299 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 166 more
Total evaluations
398
Tried for
major depressive disorder (519) Depressed mood (220)
7 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (297 evaluations)
Side effects
Anxious mood Depressed mood 66 more
Total evaluations
355
Tried for
major depressive disorder (588) Anxious mood (10)
5 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (309 evaluations)
Side effects
Dry mouth Weight gain 155 more
Total evaluations
383
Tried for
major depressive disorder (495) Depressed mood (167)
8 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (237 evaluations)
Side effects
Weight gain Nausea 119 more
Total evaluations
312
Tried for
major depressive disorder (440) Depressed mood (182)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (220 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 99 more
Total evaluations
262
Tried for
major depressive disorder (370) Anxious mood (74)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (199 evaluations)
Side effects
Sleepiness Weight gain 98 more
Total evaluations
227
Tried for
major depressive disorder (337) Depressed mood (55)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (158 evaluations)
Side effects
Drowsiness Sleepiness 42 more
Total evaluations
175
Tried for
Anxious mood (278) Insomnia (13)
3 more
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (104 evaluations)
Side effects
Dry mouth Drowsiness 49 more
Total evaluations
114
Tried for
Insomnia (208) major depressive disorder (19)
4 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 566
20s 4,532
30s 8,582
40s 12,035
50s 11,868
60s 5,616
70+ 910
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 7,032
20-29 years 2,801
30-39 years 1,930
40-49 years 1,177
50-59 years 377
60-69 years 65
70+ years 5

Sex

Distribution of sex

78% Female
22% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 17,463
Not Diagnosed 2,308

These charts show data from MDD patients who have completed their condition history
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