Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
568
Tried for
Major Depressive Disorder (527) Depressed mood (84)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
528
Tried for
Major Depressive Disorder (479) Depressed mood (116)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
479
Tried for
Major Depressive Disorder (403) Depressed mood (158)
6 more
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Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
431
Tried for
Major Depressive Disorder (427) Depressed mood (8)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
420
Tried for
Major Depressive Disorder (368) Depressed mood (122)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
388
Tried for
Major Depressive Disorder (332) Depressed mood (121)
4 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
320
Tried for
Major Depressive Disorder (302) Depressed mood (59)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
284
Tried for
Major Depressive Disorder (254) Anxious mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
266
Tried for
Anxious mood (258) Insomnia (17)
2 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
196
Tried for
Insomnia (186) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (236 evaluations)
Side effects
Anxious mood Irritability 129 more
How many evaluations
287
Tried for
Major Depressive Disorder (527) Depressed mood (84)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (216 evaluations)
Side effects
Nausea Dry mouth 115 more
How many evaluations
303
Tried for
Major Depressive Disorder (479) Depressed mood (116)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (209 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 119 more
How many evaluations
271
Tried for
Major Depressive Disorder (403) Depressed mood (158)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (146 evaluations)
Side effects
Anxious mood Depressed mood 34 more
How many evaluations
177
Tried for
Major Depressive Disorder (427) Depressed mood (8)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (208 evaluations)
Side effects
Dry mouth Weight gain 138 more
How many evaluations
253
Tried for
Major Depressive Disorder (368) Depressed mood (122)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (149 evaluations)
Side effects
Vivid dreams Nausea 98 more
How many evaluations
199
Tried for
Major Depressive Disorder (332) Depressed mood (121)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (160 evaluations)
Side effects
Headaches Sex drive (libido) decreased 86 more
How many evaluations
193
Tried for
Major Depressive Disorder (302) Depressed mood (59)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (123 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 78 more
How many evaluations
159
Tried for
Major Depressive Disorder (254) Anxious mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (126 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
147
Tried for
Anxious mood (258) Insomnia (17)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (90 evaluations)
Side effects
Grogginess Drowsy in a.m. 43 more
How many evaluations
97
Tried for
Insomnia (186) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 374
20s 3,517
30s 6,056
40s 7,380
50s 6,569
60s 2,834
70+ 425

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,347
20-29 years 2,076
30-39 years 1,393
40-49 years 802
50-59 years 234
60-69 years 31
70+ years 4

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,025
Not Diagnosed 2,118

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: