Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
579
Tried for
Major Depressive Disorder (541) Depressed mood (79)
6 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
558
Tried for
Major Depressive Disorder (506) Depressed mood (119)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
474
Tried for
Major Depressive Disorder (404) Depressed mood (138)
7 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
449
Tried for
Major Depressive Disorder (445) Depressed mood (6)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
441
Tried for
Major Depressive Disorder (387) Depressed mood (115)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
400
Tried for
Major Depressive Disorder (349) Depressed mood (113)
5 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
367
Tried for
Major Depressive Disorder (346) Depressed mood (66)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
284
Tried for
Major Depressive Disorder (254) Anxious mood (59)
1 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
274
Tried for
Anxious mood (261) Insomnia (21)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
194
Tried for
Insomnia (181) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (220 evaluations)
Side effects
Anxious mood Irritability 127 more
How many evaluations
267
Tried for
Major Depressive Disorder (541) Depressed mood (79)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (207 evaluations)
Side effects
Nausea Weight gain 122 more
How many evaluations
296
Tried for
Major Depressive Disorder (507) Depressed mood (119)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (199 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 109 more
How many evaluations
255
Tried for
Major Depressive Disorder (404) Depressed mood (138)
7 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (130 evaluations)
Side effects
Anxious mood Anxiety and frustration 31 more
How many evaluations
159
Tried for
Major Depressive Disorder (446) Depressed mood (6)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (210 evaluations)
Side effects
Dry mouth Weight gain 144 more
How many evaluations
250
Tried for
Major Depressive Disorder (388) Depressed mood (115)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (148 evaluations)
Side effects
Nausea Vivid dreams 95 more
How many evaluations
196
Tried for
Major Depressive Disorder (349) Depressed mood (113)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (165 evaluations)
Side effects
Sleepiness Headaches 82 more
How many evaluations
199
Tried for
Major Depressive Disorder (346) Depressed mood (66)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (119 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 74 more
How many evaluations
149
Tried for
Major Depressive Disorder (254) Anxious mood (59)
1 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (120 evaluations)
Side effects
Drowsiness Sleepiness 48 more
How many evaluations
144
Tried for
Anxious mood (261) Insomnia (21)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (86 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Fatigue 40 more
How many evaluations
92
Tried for
Insomnia (181) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 458
20s 3,555
30s 5,859
40s 6,989
50s 5,870
60s 2,407
70+ 347

Sex

Distribution of sex

77% Female
23% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,224
20-29 years 2,011
30-39 years 1,361
40-49 years 772
50-59 years 226
60-69 years 30
70+ years 3

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 13,728
Not Diagnosed 2,091

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: