Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
518
Tried for
Major Depressive Disorder (476) Depressed mood (109)
5 more
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Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
512
Tried for
Major Depressive Disorder (475) Depressed mood (71)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
419
Tried for
Major Depressive Disorder (416) Depressed mood (6)
5 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
390
Tried for
Major Depressive Disorder (368) Depressed mood (76)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
384
Tried for
Major Depressive Disorder (357) Depressed mood (83)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
358
Tried for
Major Depressive Disorder (337) Depressed mood (59)
2 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
347
Tried for
Major Depressive Disorder (329) Depressed mood (60)
5 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
256
Tried for
Major Depressive Disorder (232) Depressed mood (44)
3 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
215
Tried for
Anxious mood (198) Insomnia (20)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
159
Tried for
Insomnia (145) Major Depressive Disorder (24)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (184 evaluations)
Side effects
Nausea Weight gain 121 more
How many evaluations
277
Tried for
Major Depressive Disorder (476) Depressed mood (109)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (198 evaluations)
Side effects
Anxious mood Nausea 114 more
How many evaluations
234
Tried for
Major Depressive Disorder (475) Depressed mood (71)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (100 evaluations)
Side effects
Anxious mood Depressed mood 19 more
How many evaluations
125
Tried for
Major Depressive Disorder (416) Depressed mood (6)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (177 evaluations)
Side effects
Dry mouth Fatigue 107 more
How many evaluations
210
Tried for
Major Depressive Disorder (368) Depressed mood (76)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (162 evaluations)
Side effects
Dry mouth Weight gain 115 more
How many evaluations
186
Tried for
Major Depressive Disorder (357) Depressed mood (83)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (155 evaluations)
Side effects
Sex drive (libido) decreased Headaches 74 more
How many evaluations
190
Tried for
Major Depressive Disorder (337) Depressed mood (59)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (134 evaluations)
Side effects
Nausea Vivid dreams 81 more
How many evaluations
162
Tried for
Major Depressive Disorder (329) Depressed mood (60)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (105 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 72 more
How many evaluations
138
Tried for
Major Depressive Disorder (232) Depressed mood (44)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (106 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
129
Tried for
Anxious mood (198) Insomnia (20)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (74 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Grogginess 37 more
How many evaluations
80
Tried for
Insomnia (145) Major Depressive Disorder (24)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 214
20s 2,583
30s 3,898
40s 4,555
50s 3,783
60s 1,584
70+ 239

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 4,129
20-29 years 1,627
30-39 years 1,106
40-49 years 608
50-59 years 189
60-69 years 20
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,610
Not Diagnosed 1,981

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: