Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
507
Tried for
Major Depressive Disorder (464) Depressed mood (106)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
500
Tried for
Major Depressive Disorder (461) Depressed mood (73)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
433
Tried for
Major Depressive Disorder (429) Depressed mood (9)
4 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
391
Tried for
Major Depressive Disorder (369) Depressed mood (69)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
378
Tried for
Major Depressive Disorder (356) Depressed mood (76)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
364
Tried for
Major Depressive Disorder (343) Depressed mood (60)
2 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
350
Tried for
Major Depressive Disorder (331) Depressed mood (62)
5 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
265
Tried for
Major Depressive Disorder (236) Depressed mood (49)
3 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
210
Tried for
Anxious mood (192) Insomnia (21)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
152
Tried for
Insomnia (138) Major Depressive Disorder (23)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (182 evaluations)
Side effects
Nausea Weight gain 119 more
How many evaluations
275
Tried for
Major Depressive Disorder (464) Depressed mood (106)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (201 evaluations)
Side effects
Anxious mood Nausea 114 more
How many evaluations
247
Tried for
Major Depressive Disorder (461) Depressed mood (73)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (103 evaluations)
Side effects
Anxious mood Anger 15 more
How many evaluations
131
Tried for
Major Depressive Disorder (429) Depressed mood (9)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (174 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 112 more
How many evaluations
213
Tried for
Major Depressive Disorder (369) Depressed mood (69)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (157 evaluations)
Side effects
Dry mouth Weight gain 112 more
How many evaluations
189
Tried for
Major Depressive Disorder (356) Depressed mood (76)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Sex drive (libido) decreased Headaches 76 more
How many evaluations
188
Tried for
Major Depressive Disorder (343) Depressed mood (60)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (132 evaluations)
Side effects
Nausea Fatigue 85 more
How many evaluations
169
Tried for
Major Depressive Disorder (331) Depressed mood (62)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (106 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 70 more
How many evaluations
139
Tried for
Major Depressive Disorder (236) Depressed mood (49)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (99 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
121
Tried for
Anxious mood (192) Insomnia (21)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (68 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Dizziness 35 more
How many evaluations
74
Tried for
Insomnia (138) Major Depressive Disorder (23)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 199
20s 2,464
30s 3,687
40s 4,280
50s 3,630
60s 1,489
70+ 224

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 4,020
20-29 years 1,594
30-39 years 1,077
40-49 years 590
50-59 years 189
60-69 years 20
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,407
Not Diagnosed 1,969

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: