Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
567
Tried for
Major Depressive Disorder (528) Depressed mood (82)
6 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
529
Tried for
Major Depressive Disorder (481) Depressed mood (114)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
479
Tried for
Major Depressive Disorder (401) Depressed mood (158)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
423
Tried for
Major Depressive Disorder (372) Depressed mood (125)
3 more
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Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
422
Tried for
Major Depressive Disorder (418) Depressed mood (8)
6 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
385
Tried for
Major Depressive Disorder (331) Depressed mood (122)
4 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
317
Tried for
Major Depressive Disorder (299) Depressed mood (58)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
286
Tried for
Major Depressive Disorder (256) Anxious mood (63)
2 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
265
Tried for
Anxious mood (258) Insomnia (16)
2 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
197
Tried for
Insomnia (187) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (234 evaluations)
Side effects
Anxious mood Irritability 127 more
How many evaluations
287
Tried for
Major Depressive Disorder (528) Depressed mood (82)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (221 evaluations)
Side effects
Nausea Dry mouth 115 more
How many evaluations
307
Tried for
Major Depressive Disorder (481) Depressed mood (114)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (209 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 121 more
How many evaluations
274
Tried for
Major Depressive Disorder (401) Depressed mood (158)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (216 evaluations)
Side effects
Dry mouth Weight gain 141 more
How many evaluations
263
Tried for
Major Depressive Disorder (372) Depressed mood (125)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (144 evaluations)
Side effects
Anxious mood Depressed mood 38 more
How many evaluations
180
Tried for
Major Depressive Disorder (418) Depressed mood (8)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (150 evaluations)
Side effects
Vivid dreams Weight gain 98 more
How many evaluations
198
Tried for
Major Depressive Disorder (331) Depressed mood (122)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Headaches Sleepiness 88 more
How many evaluations
189
Tried for
Major Depressive Disorder (299) Depressed mood (58)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (125 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 79 more
How many evaluations
161
Tried for
Major Depressive Disorder (256) Anxious mood (63)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (126 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
146
Tried for
Anxious mood (258) Insomnia (16)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (89 evaluations)
Side effects
Grogginess Fatigue 43 more
How many evaluations
96
Tried for
Insomnia (187) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 387
20s 3,529
30s 6,145
40s 7,454
50s 6,590
60s 2,850
70+ 420

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,396
20-29 years 2,056
30-39 years 1,399
40-49 years 804
50-59 years 232
60-69 years 31
70+ years 4

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,067
Not Diagnosed 2,117

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: