Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
664
Tried for
Major Depressive Disorder (623) Depressed mood (83)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
610
Tried for
Major Depressive Disorder (556) Depressed mood (123)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
554
Tried for
Major Depressive Disorder (453) Depressed mood (207)
7 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
488
Tried for
Major Depressive Disorder (423) Depressed mood (150)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
479
Tried for
Major Depressive Disorder (475) Depressed mood (9)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
450
Tried for
Major Depressive Disorder (377) Depressed mood (149)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
344
Tried for
Major Depressive Disorder (327) Depressed mood (61)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
327
Tried for
Major Depressive Disorder (295) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
275
Tried for
Anxious mood (270) Insomnia (12)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
209
Tried for
Insomnia (200) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (322 evaluations)
Side effects
Anxious mood Headaches 152 more
How many evaluations
381
Tried for
Major Depressive Disorder (622) Depressed mood (83)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (292 evaluations)
Side effects
Dry mouth Nausea 126 more
How many evaluations
393
Tried for
Major Depressive Disorder (556) Depressed mood (123)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (257 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 140 more
How many evaluations
350
Tried for
Major Depressive Disorder (453) Depressed mood (207)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (255 evaluations)
Side effects
Dry mouth Weight gain 143 more
How many evaluations
319
Tried for
Major Depressive Disorder (423) Depressed mood (150)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (208 evaluations)
Side effects
Anxious mood Depressed mood 53 more
How many evaluations
251
Tried for
Major Depressive Disorder (475) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (195 evaluations)
Side effects
Nausea Weight gain 107 more
How many evaluations
254
Tried for
Major Depressive Disorder (377) Depressed mood (149)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (187 evaluations)
Side effects
Dry mouth Loss of sex drive (libido) 95 more
How many evaluations
218
Tried for
Major Depressive Disorder (327) Depressed mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (159 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 90 more
How many evaluations
199
Tried for
Major Depressive Disorder (295) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (148 evaluations)
Side effects
Drowsiness Sleepiness 38 more
How many evaluations
165
Tried for
Anxious mood (270) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (98 evaluations)
Side effects
Drowsiness Dry mouth 43 more
How many evaluations
105
Tried for
Insomnia (200) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 404
20s 3,744
30s 6,883
40s 8,886
50s 8,505
60s 3,991
70+ 620

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,014
20-29 years 2,321
30-39 years 1,588
40-49 years 949
50-59 years 296
60-69 years 47
70+ years 5

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 15,389
Not Diagnosed 2,186

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: