Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
572
Tried for
Major Depressive Disorder (531) Depressed mood (81)
6 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
528
Tried for
Major Depressive Disorder (478) Depressed mood (112)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
498
Tried for
Major Depressive Disorder (413) Depressed mood (178)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
435
Tried for
Major Depressive Disorder (383) Depressed mood (130)
4 more
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Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
416
Tried for
Major Depressive Disorder (412) Depressed mood (8)
6 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
395
Tried for
Major Depressive Disorder (333) Depressed mood (131)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
306
Tried for
Major Depressive Disorder (290) Depressed mood (56)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
296
Tried for
Major Depressive Disorder (266) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
257
Tried for
Anxious mood (249) Insomnia (16)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
202
Tried for
Insomnia (192) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (246 evaluations)
Side effects
Anxious mood Irritability 131 more
How many evaluations
304
Tried for
Major Depressive Disorder (531) Depressed mood (81)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (229 evaluations)
Side effects
Nausea Dry mouth 114 more
How many evaluations
320
Tried for
Major Depressive Disorder (477) Depressed mood (112)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (220 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 126 more
How many evaluations
296
Tried for
Major Depressive Disorder (413) Depressed mood (178)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (221 evaluations)
Side effects
Dry mouth Weight gain 140 more
How many evaluations
278
Tried for
Major Depressive Disorder (383) Depressed mood (130)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (155 evaluations)
Side effects
Anxious mood Depressed mood 40 more
How many evaluations
192
Tried for
Major Depressive Disorder (412) Depressed mood (8)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Nausea Weight gain 96 more
How many evaluations
206
Tried for
Major Depressive Disorder (333) Depressed mood (131)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Loss of sex drive (libido) Headaches 89 more
How many evaluations
187
Tried for
Major Depressive Disorder (290) Depressed mood (56)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (136 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 80 more
How many evaluations
172
Tried for
Major Depressive Disorder (266) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (129 evaluations)
Side effects
Drowsiness Sleepiness 38 more
How many evaluations
149
Tried for
Anxious mood (249) Insomnia (16)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (91 evaluations)
Side effects
Grogginess Drowsiness 40 more
How many evaluations
98
Tried for
Insomnia (192) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 364
20s 3,541
30s 6,265
40s 7,653
50s 6,803
60s 2,981
70+ 457

Sex

Distribution of sex

75% Female
25% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,446
20-29 years 2,086
30-39 years 1,411
40-49 years 813
50-59 years 242
60-69 years 32
70+ years 4

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,186
Not Diagnosed 2,124

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: