Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
514
Tried for
Major Depressive Disorder (472) Depressed mood (109)
5 more
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Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
513
Tried for
Major Depressive Disorder (475) Depressed mood (73)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
431
Tried for
Major Depressive Disorder (428) Depressed mood (7)
4 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
391
Tried for
Major Depressive Disorder (369) Depressed mood (70)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
380
Tried for
Major Depressive Disorder (356) Depressed mood (78)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
357
Tried for
Major Depressive Disorder (338) Depressed mood (58)
2 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
349
Tried for
Major Depressive Disorder (330) Depressed mood (61)
5 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
262
Tried for
Major Depressive Disorder (236) Depressed mood (46)
3 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
219
Tried for
Anxious mood (202) Insomnia (20)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
156
Tried for
Insomnia (142) Major Depressive Disorder (23)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (186 evaluations)
Side effects
Nausea Weight gain 119 more
How many evaluations
277
Tried for
Major Depressive Disorder (472) Depressed mood (109)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (200 evaluations)
Side effects
Anxious mood Nausea 114 more
How many evaluations
237
Tried for
Major Depressive Disorder (475) Depressed mood (73)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (106 evaluations)
Side effects
Anxious mood Anger 20 more
How many evaluations
132
Tried for
Major Depressive Disorder (428) Depressed mood (7)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (177 evaluations)
Side effects
Sex drive (libido) decreased Dry mouth 108 more
How many evaluations
210
Tried for
Major Depressive Disorder (369) Depressed mood (70)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Dry mouth Weight gain 117 more
How many evaluations
189
Tried for
Major Depressive Disorder (356) Depressed mood (78)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Sex drive (libido) decreased Headaches 76 more
How many evaluations
188
Tried for
Major Depressive Disorder (338) Depressed mood (58)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (132 evaluations)
Side effects
Nausea Fatigue 82 more
How many evaluations
168
Tried for
Major Depressive Disorder (330) Depressed mood (61)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (109 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 71 more
How many evaluations
141
Tried for
Major Depressive Disorder (236) Depressed mood (46)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (101 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
123
Tried for
Anxious mood (202) Insomnia (20)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (70 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Dizziness 35 more
How many evaluations
76
Tried for
Insomnia (142) Major Depressive Disorder (23)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 214
20s 2,515
30s 3,783
40s 4,419
50s 3,711
60s 1,534
70+ 232

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 4,079
20-29 years 1,613
30-39 years 1,091
40-49 years 597
50-59 years 190
60-69 years 20
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,513
Not Diagnosed 1,978

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: