Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
572
Tried for
Major Depressive Disorder (534) Depressed mood (79)
6 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
563
Tried for
Major Depressive Disorder (510) Depressed mood (118)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
469
Tried for
Major Depressive Disorder (403) Depressed mood (133)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
444
Tried for
Major Depressive Disorder (439) Depressed mood (6)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
433
Tried for
Major Depressive Disorder (385) Depressed mood (108)
4 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
400
Tried for
Major Depressive Disorder (350) Depressed mood (112)
5 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
361
Tried for
Major Depressive Disorder (342) Depressed mood (63)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
283
Tried for
Major Depressive Disorder (254) Anxious mood (57)
1 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
275
Tried for
Anxious mood (261) Insomnia (21)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
191
Tried for
Insomnia (179) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (219 evaluations)
Side effects
Anxious mood Irritability 125 more
How many evaluations
265
Tried for
Major Depressive Disorder (534) Depressed mood (79)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (218 evaluations)
Side effects
Nausea Weight gain 120 more
How many evaluations
302
Tried for
Major Depressive Disorder (509) Depressed mood (118)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (196 evaluations)
Side effects
Sex drive (libido) decreased Fatigue 106 more
How many evaluations
249
Tried for
Major Depressive Disorder (403) Depressed mood (133)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (124 evaluations)
Side effects
Anxious mood Anxiety and frustration 28 more
How many evaluations
150
Tried for
Major Depressive Disorder (438) Depressed mood (6)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (204 evaluations)
Side effects
Dry mouth Weight gain 139 more
How many evaluations
238
Tried for
Major Depressive Disorder (386) Depressed mood (108)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (147 evaluations)
Side effects
Nausea Vivid dreams 94 more
How many evaluations
194
Tried for
Major Depressive Disorder (350) Depressed mood (112)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (162 evaluations)
Side effects
Headaches Sex drive (libido) decreased 80 more
How many evaluations
197
Tried for
Major Depressive Disorder (343) Depressed mood (63)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (117 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 74 more
How many evaluations
146
Tried for
Major Depressive Disorder (254) Anxious mood (57)
1 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (117 evaluations)
Side effects
Drowsiness Sleepiness 48 more
How many evaluations
141
Tried for
Anxious mood (261) Insomnia (21)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (86 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Fatigue 40 more
How many evaluations
92
Tried for
Insomnia (179) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 456
20s 3,543
30s 5,798
40s 6,930
50s 5,827
60s 2,376
70+ 343

Sex

Distribution of sex

77% Female
23% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,194
20-29 years 2,003
30-39 years 1,355
40-49 years 767
50-59 years 223
60-69 years 30
70+ years 3

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 13,667
Not Diagnosed 2,090

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: