Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
504
Tried for
Major Depressive Disorder (458) Depressed mood (102)
7 more
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Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
503
Tried for
Major Depressive Disorder (471) Depressed mood (66)
6 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
404
Tried for
Major Depressive Disorder (362) Depressed mood (104)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
399
Tried for
Major Depressive Disorder (354) Depressed mood (105)
3 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
397
Tried for
Major Depressive Disorder (393) Depressed mood (5)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
350
Tried for
Major Depressive Disorder (317) Depressed mood (86)
5 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
331
Tried for
Major Depressive Disorder (316) Depressed mood (56)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
256
Tried for
Major Depressive Disorder (232) Anxious mood (50)
1 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
234
Tried for
Anxious mood (221) Insomnia (20)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
166
Tried for
Insomnia (154) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (191 evaluations)
Side effects
Nausea Weight gain 116 more
How many evaluations
270
Tried for
Major Depressive Disorder (458) Depressed mood (102)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (199 evaluations)
Side effects
Anxious mood Nausea 116 more
How many evaluations
230
Tried for
Major Depressive Disorder (471) Depressed mood (66)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (176 evaluations)
Side effects
Sex drive (libido) decreased Nausea 103 more
How many evaluations
218
Tried for
Major Depressive Disorder (362) Depressed mood (104)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (186 evaluations)
Side effects
Dry mouth Weight gain 134 more
How many evaluations
218
Tried for
Major Depressive Disorder (354) Depressed mood (105)
3 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (95 evaluations)
Side effects
Depressed mood Stress 20 more
How many evaluations
119
Tried for
Major Depressive Disorder (393) Depressed mood (5)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (129 evaluations)
Side effects
Nausea Insomnia 85 more
How many evaluations
166
Tried for
Major Depressive Disorder (317) Depressed mood (86)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (153 evaluations)
Side effects
Sex drive (libido) decreased Headaches 73 more
How many evaluations
189
Tried for
Major Depressive Disorder (316) Depressed mood (56)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (111 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 70 more
How many evaluations
141
Tried for
Major Depressive Disorder (232) Anxious mood (50)
1 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (105 evaluations)
Side effects
Drowsiness Sleepiness 49 more
How many evaluations
130
Tried for
Anxious mood (221) Insomnia (20)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (77 evaluations)
Side effects
Grogginess Excessive daytime sleepiness (somnolence) 34 more
How many evaluations
83
Tried for
Insomnia (154) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 272
20s 3,066
30s 4,864
40s 5,434
50s 4,308
60s 1,802
70+ 275

Sex

Distribution of sex

75% Female
25% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 4,452
20-29 years 1,751
30-39 years 1,178
40-49 years 649
50-59 years 199
60-69 years 24
70+ years 3

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 12,199
Not Diagnosed 2,005

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: