Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
861
Tried for
major depressive disorder (818) Depressed mood (99)
7 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
729
Tried for
major depressive disorder (679) Depressed mood (130)
9 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
655
Tried for
major depressive disorder (545) Depressed mood (237)
7 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
594
Tried for
major depressive disorder (521) Depressed mood (176)
8 more
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Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
586
Tried for
major depressive disorder (582) Depressed mood (10)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
535
Tried for
major depressive disorder (449) Depressed mood (180)
3 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
418
Tried for
major depressive disorder (384) Anxious mood (77)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
392
Tried for
major depressive disorder (375) Depressed mood (62)
2 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
309
Tried for
Anxious mood (303) Insomnia (13)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
231
Tried for
Insomnia (220) major depressive disorder (23)
4 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with major depressive disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (431 evaluations)
Side effects
Anxious mood Headaches 173 more
Total evaluations
492
Tried for
major depressive disorder (818) Depressed mood (99)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (369 evaluations)
Side effects
Dry mouth Weight gain 144 more
Total evaluations
474
Tried for
major depressive disorder (679) Depressed mood (130)
9 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (310 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 163 more
Total evaluations
415
Tried for
major depressive disorder (545) Depressed mood (237)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (313 evaluations)
Side effects
Dry mouth Weight gain 166 more
Total evaluations
393
Tried for
major depressive disorder (521) Depressed mood (176)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (285 evaluations)
Side effects
Anxious mood Depressed mood 67 more
Total evaluations
341
Tried for
major depressive disorder (582) Depressed mood (10)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (252 evaluations)
Side effects
Weight gain Nausea 128 more
Total evaluations
322
Tried for
major depressive disorder (449) Depressed mood (180)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (222 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 100 more
Total evaluations
265
Tried for
major depressive disorder (384) Anxious mood (77)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (219 evaluations)
Side effects
Sleepiness Weight gain 100 more
Total evaluations
251
Tried for
major depressive disorder (375) Depressed mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (174 evaluations)
Side effects
Drowsiness Sleepiness 43 more
Total evaluations
191
Tried for
Anxious mood (303) Insomnia (13)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (112 evaluations)
Side effects
Dry mouth Drowsiness 50 more
Total evaluations
122
Tried for
Insomnia (220) major depressive disorder (23)
4 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 561
20s 4,387
30s 8,186
40s 11,282
50s 11,061
60s 5,148
70+ 803
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,856
20-29 years 2,690
30-39 years 1,861
40-49 years 1,133
50-59 years 358
60-69 years 61
70+ years 6

Sex

Distribution of sex

77% Female
23% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 17,048
Not Diagnosed 2,284

These charts show data from MDD patients who have completed their condition history
Last updated: