What is carbidopa/entacapone/levodopa?
Levodopa is converted to a chemical called dopamine (DOE pa meen) in the brain. Symptoms of Parkinson’s disease may be caused by low levels dopamine in the brain.
Carbidopa helps prevent the breakdown of levodopa before it can reach the brain and take effect.
When used with carbidopa, entacapone, and levodopa (Atamet, Parcopa, Sinemet), entacapone increases levels of levodopa in the body.
The combination of carbidopa, entacapone, and levodopa is used to treat Parkinson symptoms such as muscle stiffness, tremors, spasms, and poor muscle control.
Carbidopa, entacapone, and levodopa may also be used for other purposes not listed in this medication guide.
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Precautions
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Instructions
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Side Effects
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Interactions
Precautions
Do not take this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) within the past 14 days.
You should not take this medication if you are allergic to carbidopa (Lodosyn), entacapone (Comtan), or levodopa (Larodopa), or if you have:
- narrow-angle glaucoma;
- unusual skin lesions that have not been checked by a doctor; or
- a history of malignant melanoma (skin cancer).
If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before you take carbidopa, entacapone, and levodopa, tell your doctor if you are allergic to any drugs, or if you have:
- heart disease, high blood pressure, coronary artery disease, a heart rhythm disorder, or a prior heart attack;
- asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;
- liver disease or bile duct obstruction;
- kidney disease;
- an endocrine (hormonal) disease;
- a stomach or intestinal ulcer;
- glaucoma; or
- depression or other mental illness.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking carbidopa, entacapone, and levodopa. It is not known whether the medicine actually causes this effect. Talk with your doctor if you believe you have any intense or unusual urges while taking carbidopa, entacapone, and levodopa.
Carbidopa, entacapone, and levodopa may cause hallucinations (the sensation of hearing or seeing something that is not there). Call your doctor if you experience hallucinations.
Some people taking medicines for Parkinson’s disease have developed skin cancer (melanoma). However, people with Parkinson's disease may have a higher risk than most people for developing melanoma. Talk to your doctor about your specific risk and what skin symptoms to watch for. You may need to have regular skin exams.
FDA pregnancy category C. It is not known whether carbidopa, entacapone, and levodopa is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.
Carbidopa, entacapone, and levodopa may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Avoid taking iron supplements or eating a diet that is high in protein (protein sources include meat, eggs, and cheese). These things can make it harder for your body to digest and absorb carbidopa, entacapone, and levodopa. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication.
Carbidopa, entacapone, and levodopa can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
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Instructions
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include weakness, loss of coordination, trouble breathing, fainting, or seizure (convulsions).
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
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Side Effects
You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- nausea, sweating, feeling like you might pass out (especially when you first start taking this medication);
- depression, confusion, hallucinations, unusual thoughts or behavior, thoughts about hurting yourself;
- twitching or uncontrollable movements of your eyes, lips, tongue, face, neck, arms, or legs;
- tremor (uncontrolled shaking);
- muscle pain, tenderness, or weakness with fever or flu symptoms;
- fast, pounding, or uneven heartbeats;
- tight feeling in your chest, trouble breathing;
- easy bruising or bleeding;
- bloody or tarry stools, coughing up blood;
- pain or burning when you urinate; or
- chest pain or heavy feeling, pain spreading to the arm or shoulder, general ill feeling.
Less serious side effects may include:
- stomach pain or upset, loss of appetite, constipation;
- dry mouth, changes in your sense of taste;
- unusual skin changes;
- dizziness or drowsiness;
- headache, blurred vision;
- sleep problems (insomnia), strange dreams;
- agitation or anxiety;
- muscle cramps, back pain; or
- mild skin rash or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
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Interactions
Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by carbidopa, entacapone, and levodopa. Tell your doctor if you regularly use any of these other medicines, or any other Parkinson’s medications..
Before taking carbidopa, entacapone, and levodopa, tell your doctor if you are taking any of the following medicines:
- apomorphine (Apokyn);
- bitolterol (Tornalate);
- cholestyramine (Prevalite, Questran);
- dobutamine (Dobutrex);
- epinephrine (Epi-Pen, and others);
- isoetharine (Bronkosol, Bronkometer);
- isoniazid (for treating tuberculosis);
- isoproterenol (Isuprel, Medihaler-Iso);
- methyldopa (Aldomet);
- metoclopramide (Reglan);
- papaverine (Pavabid, Papacon, Pavagen, Pavacot);
- phenytoin (Dilantin);
- probenecid (Benemid); or
- an antibiotic such as ampicillin, chloramphenicol, erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, and others), or rifampin (Rifadin, Rifater, Rifamate).
- blood pressure medication;
- an antidepressant such as amitriptyline (Elavil, Etrafon), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others; or
- medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), prochlorperazine (Compazine), risperidone (Risperdal), and others.
This list is not complete and there may be other drugs that can interact with carbidopa, entacapone, and levodopa. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Other Names
Stalevo 100, Stalevo 150, Stalevo 50, carbidopa/entacapone/levodopa, Stalevo 125, Stalevo 200, and Stalevo 75
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Disclaimer
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04
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