What is N-Acetylcysteine NAC?

An example of N-Acetylcysteine NAC

N-acetyl cysteine (NAC) is an altered form of the amino acid cysteine, which is commonly found in food and synthesized by the body. It is used as a mucolytic, any agent that dissolves thick mucus, to correct abnormally low glutathione levels, and for paracetamol/acetaminophen overdoses.

Reported Purpose & Perceived Effectiveness

Reasons and Perceived effectiveness
Perceived Effectiveness
Purpose # of patients # of patients with evaluations
Major
Moderate
Slight
None
Can’t tell
46 12 Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
28 5 Efficacy_none Efficacy_cant_tell
12 4 Efficacy_moderate Efficacy_cant_tell
10 0
9 0
5 0

See all 151 patients currently taking N-Acetylcysteine NAC

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Reported Side Effects

Side effects as an overall problem

Severe
2
Moderate
1
Mild
3
None
36

Commonly reported side effects, conditions, and hospitalizations associated with N-Acetylcysteine NAC

1
1
1
1
1

Reported Dosages

Frequently reported dosages based on patients currently taking N-Acetylcysteine NAC. See all 46 dosages

  600mg as needed daily 500 mg daily 600 mg daily 900 mg daily 1,000 mg daily 1,200 mg daily 1,500 mg daily 1,800 mg daily 2,000 mg daily
  3 Number of Patients: 3 6 Number of Patients: 6 16 Number of Patients: 16 39 Number of Patients: 39 4 Number of Patients: 4 7 Number of Patients: 7 24 Number of Patients: 24 3 Number of Patients: 3 14 Number of Patients: 14 5 Number of Patients: 5  

Reported Stop Reasons

Why Patients Stopped Taking N-Acetylcysteine NAC (multiple reasons could be selected)
Reason # Patients Percentage of patients
Other 20   Other: 39%
Did not seem to work 17   Did not seem to work: 33%
Course of treatment ended 7   Course of treatment ended: 14%
Doctor's advice 6   Doctor's advice: 12%
Side effects too severe 4   Side effects too severe: 8%
Personal research 3   Personal research: 6%
Expense 3   Expense: 6%
Not indicated 3   Not indicated: 6%

See all 51 patients who’ve stopped taking N-Acetylcysteine NAC

Currently Taking N-Acetylcysteine NAC

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking N-Acetylcysteine NAC

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of N-Acetylcysteine NAC

Always
24 57%
Usually
8 19%
Sometimes
6 14%
Never
4 10%

Burden

Difficulty being on treatment

Burden of N-Acetylcysteine NAC

Very
1 2%
Somewhat
3 7%
A little
6 14%
Not at all
32 76%

Cost

Paid out of pocket

Cost of N-Acetylcysteine NAC

$200+
0 0%
$100-199
0 0%
$50-99
1 5%
$25-49
5 25%
< $25
14 70%

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16 patient evaluations for N-Acetylcysteine NAC

Purpose: ALS (Amyotrophic Lateral Sclerosis) (Started Apr 25, 2011)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Dec 01, 2012 1200 mg Daily Led_efficacy_1Led_defaultLed_defaultLed_defaultNone NoneNoneNoneNoneNone UsuallyUsuallyUsuallyUsuallyUsually Not at allNot at allNot at allNot at allNot at all
Jun 20, 2011 600 mg Daily ?Can't tell NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
  • Icon_thumb_off 0 helpful marks
Purpose: Neuroprotection (Started Jun 01, 2008)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Feb 15, 2012 600 mg Daily ?Can't tell NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways A littleA littleA littleA littleA little
  • Icon_thumb_off 0 helpful marks
Purpose: General health (Started Oct 26, 2011)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Nov 22, 2011 1 cap(s) Daily ?Can't tell NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways A littleA littleA littleA littleA little
  • Icon_thumb_off 0 helpful marks
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What is acetylcysteine?

Acetylcysteine is a mucolytic (myoo-koe-LIT-ik) drug that breaks down mucus, the substance that lubricates many parts of the body such as the mouth, throat, and lungs.

Acetylcysteine is used to thin the mucus in people with certain lung conditions such as cystic fibrosis, emphysema, bronchitis, tuberculosis. Acetylcysteine is also used during surgery or anesthesia, and to prepare the throat or lungs for a medical test.

Acetylcysteine may also be used for purposes other than those listed in this medication guide.


Precautions

Do not use this medication if you are allergic to acetylcysteine.

Before using acetylcysteine, tell your doctor if you are allergic to any drugs, or if you have asthma. You may not be able to use acetylcysteine, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether acetylcysteine inhalation passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not mix other medicines in a nebulizer with acetylcysteine, unless your doctor has told you to.

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Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of an acetylcysteine overdose are not known.

Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

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Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using acetylcysteine and call your doctor at once if you have chest tightness or trouble breathing.

Less serious side effects of acetylcysteine include:

  • unusual or unpleasant smell while using the medication;
  • sticky feeling around the nebulizer mask;
  • white patches or sores inside your mouth or on your lips;
  • nausea, vomiting;
  • fever;
  • runny nose, sore throat;
  • drowsiness; or
  • skin rash or clammy feeling.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

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Interactions

There may be other drugs that can affect acetylcysteine, or that should not be used in the same nebulizer. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Acetadote, Acys-5, Mucomyst, Mucomyst-20, N-acetylcysteine, NAC, Parvolex, Parvolex (obsolete), Solgar NAC, acetylcysteine, and Mucomyst-10

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Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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