What is estradiol topical?
Estradiol (a form of estrogen) is a female sex hormone necessary for many processes in the body. Estradiol vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall.
Estradiol topical is used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination.
Estradiol may also be used for purposes other than those listed in this medication guide.
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Precautions
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Instructions
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Side Effects
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Interactions
Precautions
Do not use estradiol without first talking to your doctor if you have
- a circulation, bleeding, or blood-clotting disorder;
- undiagnosed, abnormal vaginal bleeding; or
- any type of breast, uterine, or hormone-dependent cancer.
Using estradiol may be dangerous in some cases if you have any of the conditions listed above.
Before using estradiol, tell your doctor if you have
- high blood pressure, angina, or heart disease;
- high levels of cholesterol or triglycerides in your blood;
- liver disease;
- kidney disease;
- asthma;
- epilepsy;
- migraines;
- diabetes;
- depression;
- gallbladder disease;
- uterine fibroids;
- had a hysterectomy (uterus removed);
- a narrow, short, or prolapsed vagina;
- vaginal irritation; or
- a vaginal infection.
You may not be able to use estradiol, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Treatment with estradiol long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking estradiol long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.
The Women’s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acetate.
The Women’s Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy.
Estradiol is in the FDA pregnancy category X. This means that estradiol will cause birth defects in an unborn baby. Do not use estradiol if you are pregnant or are planning a pregnancy.
Estradiol may decrease milk flow and have other effects on milk composition. Do not use estradiol without first talking to your doctor if you are breast-feeding a baby.
There are no restrictions on food, beverages, or activity while using estradiol unless your doctor directs otherwise.
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Instructions
An overdose of estradiol is unlikely to occur and is not likely to threaten life. If you do suspect an overdose, or if the medication has been ingested, call an emergency room or poison control center for advice.
Insert the next dose of cream or ring as soon as you remember. Continue to follow your regular schedule. Do not use two doses simultaneously unless your doctor directs otherwise.
If at any time the ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to reinsert it.
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Side Effects
Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using estradiol lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using estradiol. Visit your doctor regularly and report any unusual vaginal bleeding right away.
Treatment with estradiol long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking estradiol long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.
If you experience any of the following serious side effects, stop using estradiol and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- shortness or breath or pain in the chest;
- a painful, red, swollen leg;
- abnormal vaginal bleeding;
- pain, swelling, or tenderness in the abdomen;
- severe headache or vomiting, dizziness, faintness or changes in vision or speech;
- yellowing of the skin or eyes; or
- a lump in a breast.
Other, less serious side effects may be more likely to occur. Continue to use estradiol and talk to your doctor if you experience
- decreased appetite, nausea, or vomiting;
- swollen breasts;
- acne or skin color changes;
- decreased sex drive;
- migraine headaches or dizziness;
- vaginal pain, dryness, or discomfort;
- water retention (swollen hands, feet, or ankles);
- depression; or
- changes in your menstrual cycle or break-through bleeding.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
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Interactions
Before using estradiol, tell your doctor if you are taking any of the following medicines:
- an anticoagulant (blood thinner) such as warfarin (Coumadin);
- a thyroid medication such as levothyroxine (Synthroid, Levoxyl, Levothroid, and others);
- insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; or
- tamoxifen (Nolvadex).
A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above.
Do not use other vaginal products at the same times as estradiol without first talking to your doctor.
Drugs other than those listed here may also interact with estradiol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
Other Names
Estrace Vaginal Cream, Estring, Vagifem, and estradiol topical
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Disclaimer
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04
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