Before taking pentosan polysulfate sodium, tell your doctor if you have a bleeding or blood clotting disorder, a history of aneurysm or stroke, a stomach ulcer, intestinal polyps, diverticulitis, or liver disease.
Take the medicine on an empty stomach, at least 1 hour before or 2 hours after a meal.
Call your doctor at once if you have any easy bruising or unusual bleeding such as nosebleed, blood in your urine or stools, rectal bleeding, coughing up blood, bleeding gums, or feeling like you might pass out.
To be sure this medication is helping your condition, your doctor will need to check your progress every 3 months. This will help your doctor determine how long to treat you with pentosan polysulfate sodium. You may also need blood tests to check for certain side effects. Do not miss any scheduled appointments.
Tell your doctor if you use any other medications that can increase your risk of bleeding, including blood thinners, medications to treat or prevent blood clots, or an NSAID (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), indomethacin (Indocin), and others.