What is hyoscyamine?

Hyoscyamine produces many effects in the body, including relief from muscle spasms.

Hyoscyamine also reduces the fluid secretions of many organs and glands in the body, such as the stomach, pancreas, lungs, saliva glands, sweat glands, and nasal passages.

Hyoscyamine is used to treat many different stomach and intestinal disorders, including peptic ulcer and irritable bowel syndrome. It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. Hyoscyamine is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson’s disease.

Hyoscyamine is also used as a drying agent to control excessive salivation, runny nose, or excessive sweating.

Hyoscyamine may also be used for other purposes not listed in this medication guide.

Precautions

Do not take this medication if you are allergic to hyoscyamine, or if you have:

  • kidney disease;
  • an enlarged prostate or problems with urination;
  • intestinal blockage;
  • severe ulcerative colitis, or toxic megacolon;
  • glaucoma; or
  • myasthenia gravis.

Before taking this medication, tell your doctor if you are allergic to any drugs, or if you have:

  • heart disease, congestive heart failure;
  • a heart rhythm disorder;
  • high blood pressure;
  • overactive thyroid; or
  • hiatal hernia with GERD (gastroesophageal reflux disease).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take hyoscyamine.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Hyoscyamine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Avoid taking antacids at the same time you take hyoscyamine. Antacids can make it harder for your body to absorb hyoscyamine. If you use an antacid, take it after you have taken hyoscyamine and eaten a meal.

Hyoscyamine can cause side effects that may impair your vision, thinking, or reactions. Be careful if you drive or do anything that requires you to be awake and able to see clearly.

Avoid drinking alcohol. It can increase drowsiness and dizziness while you are taking hyoscyamine.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Because hyoscyamine reduces sweating, it can increase your risk of heat stroke.

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Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include headache, dizziness, dry mouth, trouble swallowing, nausea, vomiting, blurred vision, hot dry skin, and feeling restless or nervous.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using hyoscyamine and call your doctor at once if you have any of these serious side effects:

  • diarrhea;
  • confusion, hallucinations;
  • unusual thoughts or behavior;
  • fast, pounding, or uneven heart rate;
  • rash or flushing; or
  • eye pain.

Less serious side effects may include:

  • dizziness, drowsiness, feeling nervous;
  • blurred vision, headache;
  • sleep problems (insomnia);
  • nausea, vomiting, bloating, heartburn, or constipation;
  • changes in taste;
  • problems with urination;
  • decreased sweating;
  • dry mouth; or
  • impotence, loss of interest in sex, or trouble having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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Interactions

Before taking this medication, tell your doctor if you are using any of the following drugs:

  • amantadine (Symmetrel);
  • haloperidol (Haldol);
  • an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
  • phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine); or
  • antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

This list is not complete and there may be other drugs that can interact with hyoscyamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

A-Spas S/L, Anaspaz, Cystospaz, Cystospaz-M, Donnamar, Hyosol, Hyospaz, Hyosyne, IB-Stat, L-hyoscyamine, Levbid, Levsin, Levsin SL, Levsinex SR, Spasdel, Symax Duotab, Symax SL, Symax SR, hyoscyamine, HyoMax DT, HyoMax FT, HyoMax SL, HyoMax SR, Nulev, NuLev, and Symax FasTab

Available Strengths & Dosages


Route Form Strength
oral tablet, disintegrating 0.125 mg

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Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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