Keppra XR Treatment Report

Category: Prescription Drugs

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Generic Name: Levetiracetam

What is Keppra XR?

An example of Keppra XR

Keppra XR™ is a brand name for the extended release formulation of levetiracetam, an anticonvulsant. It is used as adjunctive therapy in the treatment of partial onset, myoclonic, and/or primary generalized tonic-clonic seizures. Off label it is used for bipolar disorder.

Reported Purpose & Perceived Effectiveness

Reasons and Perceived effectiveness
Perceived Effectiveness
Purpose # of patients # of patients with evaluations
Major
Moderate
Slight
None
Can’t tell
120 59 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
11 3 Efficacy_major Efficacy_moderate Efficacy_slight
8 4 Efficacy_major Efficacy_moderate
7 2 Efficacy_major Efficacy_slight
2 1 Efficacy_major
2 1 Efficacy_slight

See all 130 patients currently taking Keppra XR

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Reported Side Effects

Side effects as an overall problem

Severe
10
Moderate
22
Mild
22
None
13

Commonly reported side effects, conditions, and hospitalizations associated with Keppra XR

6
6
6
5
4
4
See all 70 reported side effects See top 6 reported side effects

Reported Dosages

Frequently reported dosages based on patients currently taking Keppra XR. See all 74 dosages

  250 mg daily 500 mg daily 750 mg daily 1,000 mg daily 1,500 mg daily 2,000 mg daily 2,250 mg daily 2,500 mg daily 3,000 mg daily 4,000 mg daily
  28 Number of Patients: 28 133 Number of Patients: 133 31 Number of Patients: 31 263 Number of Patients: 263 172 Number of Patients: 172 200 Number of Patients: 200 17 Number of Patients: 17 44 Number of Patients: 44 209 Number of Patients: 209 47 Number of Patients: 47  

Reported Stop Reasons

Why Patients Stopped Taking Keppra XR (multiple reasons could be selected)
Reason # Patients Percentage of patients
Side effects too severe 13   Side effects too severe: 46%
Doctor's advice 12   Doctor's advice: 43%
Did not seem to work 10   Did not seem to work: 36%
Other 5   Other: 18%
Expense 4   Expense: 14%
Personal research 1   Personal research: 4%
Change in health plan coverage 1   Change in health plan coverage: 4%
Not indicated 1   Not indicated: 4%

See all 28 patients who’ve stopped taking Keppra XR

Currently Taking Keppra XR

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0
0

Stopped Taking Keppra XR

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Keppra XR

Always
65 97%
Usually
2 3%
Sometimes
0 0%
Never
0 0%

Burden

Difficulty being on treatment

Burden of Keppra XR

Very
2 3%
Somewhat
2 3%
A little
10 15%
Not at all
53 79%

Cost

Paid out of pocket

Cost of Keppra XR

$200+
6 13%
$100-199
4 8%
$50-99
14 29%
$25-49
11 23%
< $25
13 27%

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14 patient evaluations for Keppra XR

  • neuroplasticity
    Data Quality: 2 stars
    • Sex: M
    • Age: 53y
    • Duration: 40 yrs
    PRO survey: PRO 3
    Quality of Life:
    • Mental: Moderate
    • Physical: Mild
    Surgery type: Selective Amygdalohippocampectomy, Vagus Nerve Stimulation (VNS), Extratemporal Resection
    0 seizures
    30 weeks ago
  • 35926-thumb
  • See neuroplasticity's full Keppra XR history
Purpose: Epilepsy (Started Apr 12, 2009)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Nov 29, 2012 2000 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate ModerateModerateModerateModerateModerate AlwaysAlwaysAlwaysAlwaysAlways A littleA littleA littleA littleA little
Jul 07, 2011 2000 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Side effects:
Vision loss in left side of visual field for both eyes, Nose itch, Paranoia
  • Icon_thumb_off 0 helpful marks
Purpose: Parkinson's Disease (Started Nov 19, 2010)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Nov 18, 2012 500 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate SevereSevereSevereSevereSevere AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
  • Icon_thumb_off 0 helpful marks
  • Tonialpha
    Data Quality: 2 stars
    • Sex: F
    • Age: 59y
    • Duration: 46 yrs
    PRO survey: PRO 3
    Quality of Life:
    • Mental: None
    • Physical: None
    Surgery type: Left Temporal Lobectomy, Selective Amygdalohippocampectomy, Vagus Nerve Stimulation (VNS)
    10 seizures
    5 weeks ago
  • 21423-thumb
  • See Tonialpha's full Keppra XR history
Purpose: Epilepsy (Started Aug 14, 2010)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Feb 07, 2012 6000 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate ModerateModerateModerateModerateModerate AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
May 30, 2010   Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate MildMildMildMildMild AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Side effects:
Stomach upset, Anxious mood
Date
Feb 07, 2012
Advice & Tips
THE XR IS THE BEST THE KEPPRA IS THE BEST. THE MAIL ORDER SENT ME THE GENERIC THE OTHER WEEK AND I TRIED IT AND I NOTICED SEIZURE ACTIVITY THAT DAY. SWALLOWING AND NAUSEA IS MY BIGGEST ISSUE BUT THE SEIZURES ARE A LOT BETTER!
Cost
< $25 monthly
Date
May 30, 2010
Advice & Tips
timer from e-pill for taking pills 5 times a day. timer on phone and pill box
Cost
< $25 monthly
  • Icon_thumb_off 0 helpful marks
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What is levetiracetam?

Levetiracetam is an anti-epileptic drug.

Levetiracetam is used to treat partial onset seizures in adults and children who are at least 4 years old.

Levetiracetam is also used to treat tonic-clonic seizures in adults and children who are at least 6 years old, and myoclonic seizures in adults and children who are at least 12 years old.

Levetiracetam may also be used for other purposes not listed in this medication guide.


Precautions

You should not use this medication if you are allergic to levetiracetam.

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have kidney disease. You may need a dose adjustment or special tests during treatment.

You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

FDA pregnancy category C. It is not known whether levetiracetam is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

Levetiracetam can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to a child without the advice of a doctor.

Avoid drinking alcohol. It can increase some of the side effects of levetiracetam and may also increase the risk of seizures.

Levetiracetam can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

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Instructions

Seek emergency medical treatment if you think you have used too much of this medicine.

Overdose symptoms may include drowsiness, agitation, aggression, shallow breathing, weakness, or fainting.

If you have missed your dose by only a few hours, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

  • hallucinations;
  • fever, chills, body aches, flu symptoms;
  • weakness, lack of coordination;
  • increasing or worsening seizures; or
  • nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • dizziness, spinning sensation;
  • drowsiness;
  • feeling irritable;
  • headache;
  • runny nose, sore throat; or
  • neck pain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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Interactions

There may be other drugs that can interact with levetiracetam. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Keppra, levetiracetam, and Keppra XR

Available Strengths & Dosages


Route Form Strength
oral tablet, extended release 500 mg
oral tablet, extended release 750 mg

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Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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