What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

true

Generic Name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Reported purpose & perceived effectiveness
Purpose Patients Patients with evaluations Perceived Effectiveness
393 173
95 57
87 45
32 16
31 16
29 19

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

side_effects of Low Dose Naltrexone (LDN)"

Severe
19
Moderate
24
Mild
67
None
227

Commonly reported side effects, conditions, and hospitalizations associated with Low Dose Naltrexone (LDN)

20
9
9
8
6
5

Dosages

Most common dosages (by patients currently taking Low Dose Naltrexone (LDN))
Dosage Patients
4.5 mg daily 298
3 mg daily 148
1.5 mg daily 36
4 mg daily 35
3.5 mg daily 23
1 mg daily 21
2 mg daily 10
2.5 mg daily 7
5 mg daily 7
daily 6
Why Patients Stopped Taking Low Dose Naltrexone (LDN) (multiple reasons could be selected)
Reason Patients
Did not seem to work 96
Other 50
Side effects too severe 36
Doctor's advice 27
Expense 9
Personal research 8
Course of treatment ended 5
Not indicated 5
Change in health plan coverage 2
See all 181 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 0
1-3 months 2
3-6 months 3
6 months-1 year 16
1-2 years 20
2 years or more 125
Stopped Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 17
1-3 months 31
3-6 months 34
6 months-1 year 24
1-2 years 48
2 years or more 27
Adherence
Always
290 86%
Usually
36 11%
Sometimes
5 1%
Never
6 2%
Burden
Very
6 2%
Somewhat
16 5%
A little
27 8%
Not at all
288 85%
Cost
$200+
0 0%
$100-199
2 1%
$50-99
39 13%
$25-49
160 52%
< $25
104 34%
Last updated:

63 patient evaluations for Low Dose Naltrexone (LDN)

gridly1
27338 thumb
gridly1
Sex: F
Data Quality: 3 stars
Pain: Most
Fatigue: Most
Sleep: All
Stiffness: All
function: Little
external_stress: Most
Stickman: all
Description:F55y
CFS:?y
FM:6y Dx
I am: b
I have:
ME/CFS

See gridly1's full Low Dose Naltrexone (LDN) history

Jan 28, 2014 (Started Nov 22, 2013)

  • Perceived effectiveness for Fibromyalgia: Major
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily
Advice & Tips: When you start LDN you need to get off ALL opioids because they conflict. At first I was in pain all the time (4-7 out of 10)+ had Constant daytime drowsiness + vivid dreams every night. With in the week I started smiling instead of Grimacing all the time. Hygiene and house cleaning has become less troubling. After 2 months, the "Whole body" pain has decreased in intensity (now 2-4), allowing me to be able to identify and address specific symptoms w/ my doc. PLUS I've needed only 1or 2 NSAIDs a day! About two months in the drowsiness started to subside + the vivid dreams have been less noticeable!
Cost: < $25 monthly

Dec 13, 2013 (Started Nov 22, 2013)

  • Perceived effectiveness for Fibromyalgia: Moderate
  • Side Effects: Mild
  • Adherence: Always
  • Burden: A little
Dosage: 4.5 mg Daily
Advice & Tips: LDN Helps stimulate endorphins. I seem to be in a better mood (not grimacing as much) and my symptoms seem to be less bothersome. I experience more drowsiness .
Cost: $50-99 monthly

  • 0 helpful marks
EdSikov
52249 thumb
EdSikov
Sex: M
Data Quality: 2 stars
On
Mouth/throat: none
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See EdSikov's full Low Dose Naltrexone (LDN) history

Sep 12, 2013 (Started Jan 17, 2013)

  • Perceived effectiveness for Sleep problems: None
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily

  • 0 helpful marks
ukiwi
9816 thumb
ukiwi
Sex: M
Data Quality: 3 stars
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: moderate
Speech: none
Swallowing: none
Upper limb: none
Walking: mild
I am: n
I have:
MS

See ukiwi's full Low Dose Naltrexone (LDN) history

Jul 1, 2013 (Started Jan 17, 2013)

  • Perceived effectiveness for Multiple Sclerosis: None
  • Perceived effectiveness for Fatigue: None
  • Perceived effectiveness for Cognitive impairment: None
  • Side Effects: None
  • Adherence: Always
  • Burden: Somewhat
Dosage: 3 mg Daily
Cost: $100-199 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 63 patient evaluations for Low Dose Naltrexone (LDN)