What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

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Generic Name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Reported purpose & perceived effectiveness
Purpose Patients Patients with evaluations Perceived Effectiveness
391 171
92 55
84 43
32 16
31 16
27 19

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

side_effects of Low Dose Naltrexone (LDN)"

Severe
19
Moderate
24
Mild
66
None
223

Commonly reported side effects, conditions, and hospitalizations associated with Low Dose Naltrexone (LDN)

19
9
9
8
6
5

Dosages

Most common dosages (by patients currently taking Low Dose Naltrexone (LDN))
Dosage Patients
daily 6
1 mg daily 18
1.5 mg daily 37
2 mg daily 11
2.5 mg daily 7
3 mg daily 149
3.5 mg daily 23
4 mg daily 35
4.5 mg daily 289
5 mg daily 6
Why Patients Stopped Taking Low Dose Naltrexone (LDN) (multiple reasons could be selected)
Reason Patients
Did not seem to work 96
Other 51
Side effects too severe 37
Doctor's advice 27
Personal research 8
Expense 8
Course of treatment ended 5
Not indicated 5
Change in health plan coverage 1
See all 180 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 1
1-3 months 3
3-6 months 10
6 months-1 year 19
1-2 years 17
2 years or more 121
Stopped Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 17
1-3 months 31
3-6 months 33
6 months-1 year 26
1-2 years 45
2 years or more 28
Adherence
Always
286 86%
Usually
35 11%
Sometimes
5 2%
Never
6 2%
Burden
Very
5 2%
Somewhat
15 5%
A little
26 8%
Not at all
286 86%
Cost
$200+
0 0%
$100-199
2 1%
$50-99
38 13%
$25-49
157 52%
< $25
104 35%
Last updated:

64 patient evaluations for Low Dose Naltrexone (LDN)

gridly1
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gridly1
Sex: F
Data Quality: 2 stars
Pain: Most
Fatigue: All
Sleep: Most
Stiffness: All
function: None
external_stress: Most
Stickman: all
Description:F54y
FM:5y Dx
CFS:?y
I am: b
I have:
ME/CFS

See gridly1's full Low Dose Naltrexone (LDN) history

Jan 28, 2014 (Started Nov 22, 2013)

  • Perceived effectiveness for Fibromyalgia: Major
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily
Advice & Tips: When you start LDN you need to get off ALL opioids because they conflict. At first I was in pain all the time (4-7 out of 10)+ had Constant daytime drowsiness + vivid dreams every night. With in the week I started smiling instead of Grimacing all the time. Hygiene and house cleaning has become less troubling. After 2 months, the "Whole body" pain has decreased in intensity (now 2-4), allowing me to be able to identify and address specific symptoms w/ my doc. PLUS I've needed only 1or 2 NSAIDs a day! About two months in the drowsiness started to subside + the vivid dreams have been less noticeable!
Cost: < $25 monthly

Dec 13, 2013 (Started Nov 22, 2013)

  • Perceived effectiveness for Fibromyalgia: Moderate
  • Side Effects: Mild
  • Adherence: Always
  • Burden: A little
Dosage: 4.5 mg Daily
Advice & Tips: LDN Helps stimulate endorphins. I seem to be in a better mood (not grimacing as much) and my symptoms seem to be less bothersome. I experience more drowsiness .
Cost: $50-99 monthly

  • 0 helpful marks
EdSikov
52249-thumb
EdSikov
Sex: M
Data Quality: 3 stars
On
Mouth/throat: none
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See EdSikov's full Low Dose Naltrexone (LDN) history

Sep 12, 2013 (Started Jan 17, 2013)

  • Perceived effectiveness for Sleep problems: None
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily

  • 0 helpful marks
ukiwi
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ukiwi
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: moderate
Speech: mild
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: g
I have:
MS

See ukiwi's full Low Dose Naltrexone (LDN) history

Jul 1, 2013 (Started Jan 17, 2013)

  • Perceived effectiveness for Cognitive impairment: None
  • Perceived effectiveness for Fatigue: None
  • Perceived effectiveness for Multiple Sclerosis: None
  • Side Effects: None
  • Adherence: Always
  • Burden: Somewhat
Dosage: 3 mg Daily
Cost: $100-199 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 64 patient evaluations for Low Dose Naltrexone (LDN)