What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

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Generic Name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Reported purpose & perceived effectiveness
Purpose Patients Patients with evaluations Perceived Effectiveness
396 180
99 60
92 47
32 16
31 16
29 19

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

side_effects of Low Dose Naltrexone (LDN)"

Severe
19
Moderate
24
Mild
68
None
239

Commonly reported side effects, conditions, and hospitalizations associated with Low Dose Naltrexone (LDN)

20
9
9
8
6
5

Show all 103 reported side effects

Dosages

Most common dosages (by patients currently taking Low Dose Naltrexone (LDN))
Dosage Patients
4.5 mg daily 301
3 mg daily 150
1.5 mg daily 37
4 mg daily 35
3.5 mg daily 24
1 mg daily 22
2 mg daily 11
5 mg daily 9
2.5 mg daily 7
daily 6
Why Patients Stopped Taking Low Dose Naltrexone (LDN) (multiple reasons could be selected)
Reason Patients
Did not seem to work 96
Other 50
Side effects too severe 35
Doctor's advice 26
Expense 10
Personal research 9
Course of treatment ended 5
Not indicated 5
Change in health plan coverage 3
See all 185 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 1
1-3 months 4
3-6 months 4
6 months-1 year 12
1-2 years 21
2 years or more 126
Stopped Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 17
1-3 months 31
3-6 months 35
6 months-1 year 24
1-2 years 49
2 years or more 28
Adherence
Always
302 86%
Usually
36 10%
Sometimes
5 1%
Never
7 2%
Burden
Very
5 1%
Somewhat
17 5%
A little
31 9%
Not at all
297 85%
Cost per month
$200+
0 0%
$100-199
2 1%
$50-99
41 13%
$25-49
166 53%
< $25
105 33%

What people switch to and from

Patients started taking Low Dose Naltrexone (LDN) after stopping:
Treatment name(s) Patients
Donepezil (Aricept, Aricept ODT) 1
Doxepin (Sinequan, Silenor, Deptran…) 1
Gabapentin (Neurontin, Ratio-Gabapentin, Gabatin…) 1
Hydrocodone-Acetaminophen (Vicodin, Norco, Vicodin ES…) 1
Pregabalin (Lyrica, Maxgalin, Provelyn) 1

See all 8 treatments patients report switching from

Patients stopped taking Low Dose Naltrexone (LDN) and switched to:
Treatment name(s) Patients
Hydroxychloroquine (Plaquenil, Hydroxychlor, Apo-hydroxyquine…) 1
Last updated:

63 patient evaluations for Low Dose Naltrexone (LDN)

gummitarzan
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gummitarzan
Data Quality: 3 stars
  • Sex: M
  • Age: 67
Condition: RA (Rheumatoid Arthritis) 5 additional condition(s)
Quality of Life:
  • Mental: Mild
  • Physical: Mild
I am: n
I have:
RA (Rheumatoid Arthritis)

See gummitarzan's full Low Dose Naltrexone (LDN) history

Mar 10, 2015 (Started Jan 31, 2015)

  • Perceived effectiveness for RA (Rheumatoid Arthritis): Can’t tell
  • Side Effects: None
  • Adherence: Usually
  • Burden: A little
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
gridly1
27338 thumb
gridly1
Sex: F
Data Quality: 1 star
Pain: Most
Fatigue: Most
Sleep: All
Stiffness: All
function: None
external_stress: Most
Stickman: all
Description:F55y
FM:6y Dx
CFS:?y
I am: b
I have:
ME/CFS

See gridly1's full Low Dose Naltrexone (LDN) history

Jan 28, 2014 (Started Nov 22, 2013)

  • Perceived effectiveness for Fibromyalgia: Major
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily
Advice & Tips: When you start LDN you need to get off ALL opioids because they conflict. At first I was in pain all the time (4-7 out of 10)+ had Constant daytime drowsiness + vivid dreams every night. With in the week I started smiling instead of Grimacing all the time. Hygiene and house cleaning has become less troubling. After 2 months, the "Whole body" pain has decreased in intensity (now 2-4), allowing me to be able to identify and address specific symptoms w/ my doc. PLUS I've needed only 1or 2 NSAIDs a day! About two months in the drowsiness started to subside + the vivid dreams have been less noticeable!
Cost: < $25 monthly

Dec 13, 2013 (Started Nov 22, 2013)

  • Perceived effectiveness for Fibromyalgia: Moderate
  • Side Effects: Mild
  • Adherence: Always
  • Burden: A little
Dosage: 4.5 mg Daily
Advice & Tips: LDN Helps stimulate endorphins. I seem to be in a better mood (not grimacing as much) and my symptoms seem to be less bothersome. I experience more drowsiness .
Cost: $50-99 monthly

  • 0 helpful marks
EdSikov
52249 thumb
EdSikov
Sex: M
Data Quality: 2 stars
On
Mouth/throat: none
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See EdSikov's full Low Dose Naltrexone (LDN) history

Sep 12, 2013 (Started Jan 17, 2013)

  • Perceived effectiveness for Sleep problems: None
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 63 patient evaluations for Low Dose Naltrexone (LDN)