What is Hereditary Spastic Paraplegia?

Hereditary Spastic Paraplegia is not a single disease but a group of genetic disorders in which the main feature is progressive spasticity in the lower limbs due to pyramidal tract dysfunction. Onset can be at any age, from the first year of life to old age, depending on the specific genetic form.

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What do patients take to treat Hereditary Spastic Paraplegia and its symptoms?

Commonly prescribed and frequently used treatments

Treatment name Efficacy Overall rating of side effects # of Evaluations
Baclofen
(Kemstro, DOM-Baclofen, Gabalon, Spinax)
1
Diazepam
(Diastat Pediatric, PsychoPax, Antenex, Diastat)
1
Clonazepam
(DOM-Clonazepam, Paxam, APO Clonazepam, Clonotril)
1
Tizanidine HCl
(Sirdalud Retard, Sirdalud, Zanaflex)
0

These charts show data from Hereditary Spastic Paraplegia patients' latest treatment evaluations

Who has Hereditary Spastic Paraplegia at PatientsLikeMe?

<20 20-29 30-39 40-49 50-59 60-69 70+
Current Age
Distribution of females vs. males
Gender
59% Females
41% Males
Age at first symptom
Age at first symptom # of patients Proportion
0-19 yrs 11
20-29 yrs 2
30-39 yrs 9
40-49 yrs 8
50-59 yrs 8
60-69 yrs 0
70+ yrs 0
Diagnosis status
Diagnosis status # of patients Proportion
Diagnosed 44
Not Officially Diagnosed 3

These charts show data from Hereditary Spastic Paraplegia patients who have completed their condition history