Major Depressive Disorder

We’re all in this for good.

By sharing your stories and data, you will:
  • help each other live better and uncover the best ways to manage your health today
  • help researchers shorten the path to new treatments tomorrow

How much good can your data do? A whole lot, as co-founder Jamie Heywood explains in this video.

What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

What is it like to have Major Depressive Disorder?

Common symptoms How bad it is What people are taking for it
Amphetamine-Dextroamphetamine, Modafinil, Methylphenidate
Individual Therapy, Amphetamine-Dextroamphetamine, Lisdexamfetamine
Methylphenidate, Lisdexamfetamine, Amphetamine-Dextroamphetamine
Bupropion, Citalopram, Fluoxetine
Venlafaxine, Amphetamine-Dextroamphetamine, Duloxetine
Clonazepam, Alprazolam, Lorazepam
Ibuprofen, Acetaminophen (Paracetamol), Topiramate
Trazodone, Zolpidem, Quetiapine
Individual Therapy, Positive self-talk, Work
Cyclobenzaprine, Massage Therapy, Clonazepam
Promethazine, Ondansetron, Metoclopramide
Hydrocodone, Lidocaine Transdermal, Ibuprofen
Tramadol, Hydrocodone-Acetaminophen, Gabapentin
Scopolamine, Omeprazole OTC, Pantoprazole
Prochlorperazine, Meclizine, Meclizine Prescription
Alprazolam, Meditation, Clonazepam

What do patients take to treat Major Depressive Disorder and its symptoms?

Treatments reported by members Perceived effectiveness Overall rating of side effects # of Evaluations

(Psychosexual therapy, Psychiatrist and Psychologist, Integrative Counselling, Licensed Social Worker)


(Forfivo XL, Voxra, Novo-Bupropion, Bupropion SR)


(Venlalic XL, Zarelis, Venlor XR, Novo-Venlafaxine XR)


(Yentreve, Cymgen, Yelate, Cymbalta)


(Nuzak, Flunil, Zactin, Nopres)


(Ran-Citalo, Depramil, Citalec, Co-Citalopram)


(Gladem, Serdep, Apo-Sertraline, Altruline)


(Pramatis, Es Pramcit, Loxalate, Esopram)


(ADCO Mirteron, Avanza, Mirzaten, Rexer)




(Bilateral Electroconvulsive Therapy ECT, Unilateral Electroconvulsive Therapy ECT, Bifrontal Electroconvulsive Therapy ECT)


(Zedan, Amirozole, Abilify Discmelt, Abilify)


(Lamictal Starter Kit (Orange), Lamictin, Lamictal Green, Lamogine)




(Ratio-Quetiapine, Dopaquel, Ketipinor, Cobalt-Quetiapine)


These charts show data from Major Depressive Disorder patients’ latest treatment evaluations
Last updated:

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?

  • 15,025 patients have this condition
  • 67 new patients joined this month
  • 5,505 say Major Depressive Disorder is their primary condition

Age Proportion # of patients
<20 273
20s 2,424
30s 3,245
40s 3,613
50s 2,838
60s 987
70+ 135


Distribution of females vs. males

78% Females
22% Males
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 3,550
20-29 years 1,412
30-39 years 938
40-49 years 506
50-59 years 154
60-69 years 16
70+ years 3

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 10,412
Not Diagnosed 1,962

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: