What is Entacapone?

Category: Prescription Drugs

Most popular types: Comtan Comtess

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Entacapone is an inhibitor of catechol-O-methyltransferase (COMT) and is used as an adjunct treatment for patients taking levodopa and carbidopa for Parkinson’s Disease who experience the signs and symptoms of end-of-dose “wearing-off”.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 361 140
Increase effect of another treatment 57 37
Wearing off effect 36 17
Stiffness/spasticity 5 3
Improve mobility 2 1
Slow movement (bradykinesia) 2 1

Show all 11 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 14
Moderate 33
Mild 38
None 75

Commonly reported side effects and conditions associated with Entacapone

Side effect Patients
Jerky movements 10
Nausea 9
Diarrhea 8
Digestive problems 5
Constipation 3
Loose bowel movements 3

Show all 53 reported side effects

Dosages

Based on patients currently taking Entacapone

Dosage Patients
800 mg daily 11
200 mg three times daily 10
200 mg four times daily 10
600 mg daily 9
200 mg daily 5
200 mg twice daily 5
1,000 mg daily 4
200 mg five times daily 4
400 mg daily 2
400 mg twice daily 2

See all 16 dosages

Why patients stopped taking Entacapone

Multiple reasons could be selected

Reason Patients
Side effects too severe 52
Did not seem to work 37
Doctor's advice 31
Other 20
Expense 11
Course of treatment ended 4
Personal research 2
Change in health plan coverage 1
See all 120 patients who've stopped taking Entacapone

Duration

Currently taking Entacapone

Duration Patients
1 - 6 months 2
6 months - 1 year 6
1 - 2 years 13
2 - 5 years 20
5 - 10 years 23
10 years or more 7

Stopped taking Entacapone

Duration Patients
Less than 1 month 23
1 - 6 months 34
6 months - 1 year 18
1 - 2 years 13
2 - 5 years 21
5 - 10 years 10
10 years or more 1
Adherence
Adherence Evaluations
Always 115
Usually 27
Sometimes 0
Never taken as prescribed 18
Burden
Burden Evaluations
Very hard to take 8
Somewhat hard to take 14
A little hard to take 23
Not at all hard to take 115
Cost per month
Cost per month Evaluations
$200+ 12
$100-199 3
$50-99 11
$25-49 24
< $25 50
Not specified 60

What people switch to and from

Patients started taking Entacapone after stopping:

Treatment Patients
Carbidopa-Entacapone-Levodopa (Stalevo) 3
Carbidopa-Levodopa (Sinemet) 2
Apomorphine (Apokyn) 1
Ropinirole (Requip) 1
Tolcapone (Tasmar) 1

Show all 6 treatments patients report switching from

Patients stopped taking Entacapone and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 8
Carbidopa-Levodopa (Sinemet) 3
Carbidopa-Entacapone-Levodopa (Stalevo) 1
Carbidopa-Levodopa CR (Sinemet CR) 1
Deep Brain Stimulation (Subthalamic Nucleus Deep Brain Stimulation) 1

Show all 8 treatments patients report switching to

Last updated:

17 patient evaluations for Entacapone

Jan 26, 2017 (Started Feb 15, 2016)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Five times daily
Advice & Tips: Must be taken with C/L dosage.  My effects vary with duration, but I have bad off time wear off; which is why i am trying DBS.
Cost: < $25 monthly

  • 0 helpful marks

Jan 15, 2017 (Started Mar 20, 2010)

  • Effectiveness
    Major (for wearing off effect)
  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: I have not been on at 10 PM for some time (a year or two or more). But I no longer take comtan because I have had DBS.
Cost: $25-49 monthly
Side effects: orange colored urine

May 22, 2010 (Started Mar 20, 2010)

  • Effectiveness
    Major (for wearing off effect)
  • Side effects
    Mild (orange colored urine)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 600 mg Daily
Advice & Tips: Since going to three doses a day, I frequently have no off time, from about half an hour after I take the medication first thing in the AM, until 8 or 9 at night. Sometimes I"m still on at 10 PM when I go to bed.
Cost: $25-49 monthly
Side effects: orange colored urine

  • 0 helpful marks

Feb 24, 2016 (Started Feb 17, 2012)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 800 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 17 patient evaluations for Entacapone