What is grape seed oil?

The use of grape seed in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

Grape seed is also known as Vitis vinifera.

Grape seed has been used as a dietary source of essential fatty acids and tocopherols and as an antioxidant. Grape seed had been used for its liver protective effects, to improve circulation (including conditions such as varicose veins, bruising, swelling, and decreased vision), and to improve skin tone and elasticity.

Grape seed has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of grape seed may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Grape seed may also have uses other than those listed in this medication guide.


Before taking grape seed, talk to your doctor, pharmacist, or health care professional if you have any other medical conditions, allergies (especially to plants or foods), or if you take other medicines or other herbal/health supplements. Grape seed may not be recommended in some situations.

Do not take grape seed without first talking to your doctor if you are pregnant or planning a pregnancy. It is not known whether grape seed will harm an unborn baby.

Do not take grape seed without first talking to your doctor if you are breast-feeding a baby. It is not known whether grape seed will harm a nursing infant.

There is no information available regarding the use of grape seed by children. Do not give any herbal/health supplement to a child without first talking to the child’s doctor.

There are no known restrictions on food, beverages, or activity while taking grape seed, unless otherwise directed by your health care professional.

Back to top


Seek emergency medical attention.

Symptoms of a grape seed overdose are not known.

No information is available regarding a missed dose of grape seed. Consult your doctor, pharmacist, or health care professional if you require further information.

Back to top

Side effects

Although rare, allergic reactions to grape seed may be possible. Stop taking grape seed and seek emergency medical attention if you experience symptoms of a serious allergic reaction including difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives.

No other side effects have been reported with the use of grape seed. Talk to your doctor, pharmacist, or health care professional about any side effect that seems unusual or that is especially bothersome.

Back to top


No interactions between grape seed and other medicines have been reported, although they are possible. Talk to your doctor, pharmacist, or health care professional before taking any prescription or over-the-counter medicines or other herbal/health supplements.

Other Names

grape seed oil

Back to top


Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: