What is Modafinil?

Category: Prescription Drugs

Most popular types: Provigil Alertec Modiodal Show all

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Modafinil is stimulant used to improve wakefulness in patients narcolepsy and shift work sleep disorder or as an adjunctive therapy for obstructive sleep apnea. It may also be used for attention-deficit/hyperactivity disorder and to treat fatigue in MS and other disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fatigue 1,530 714
Multiple sclerosis 921 433
Excessive daytime sleepiness (somnolence) 517 356
Narcolepsy 106 57
Brain fog 81 53

Show all 94 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 73
Moderate 158
Mild 259
None 638

Commonly reported side effects and conditions associated with Modafinil

Side effect Patients
Jittery feeling 58
Headaches 57
Dry mouth 51
Anxious mood 36
Tachycardia (fast heart rate) 31
Sleep problems 29

Show all 179 reported side effects

Dosages

Based on patients currently taking Modafinil

Dosage Patients
200 mg daily 115
100 mg daily 70
400 mg daily 39
200 mg twice daily 16
100mg as needed 9
200mg as needed 9
100 mg twice daily 8
400 mg twice daily 5
150 mg daily 3
300 mg daily 3

See all 30 dosages

Why patients stopped taking Modafinil

Multiple reasons could be selected

Reason Patients
Did not seem to work 287
Other 205
Side effects too severe 198
Expense 183
Doctor's advice 119
Change in health plan coverage 92
Personal research 36
Course of treatment ended 19
See all 884 patients who've stopped taking Modafinil

Duration

Currently taking Modafinil

Duration Patients
1 - 6 months 12
6 months - 1 year 14
1 - 2 years 21
2 - 5 years 50
5 - 10 years 114
10 years or more 89

Stopped taking Modafinil

Duration Patients
Less than 1 month 132
1 - 6 months 183
6 months - 1 year 127
1 - 2 years 145
2 - 5 years 197
5 - 10 years 76
10 years or more 26
Adherence
Adherence Evaluations
Always 767
Usually 226
Sometimes 98
Never taken as prescribed 37
Burden
Burden Evaluations
Very hard to take 36
Somewhat hard to take 65
A little hard to take 141
Not at all hard to take 886
Cost per month
Cost per month Evaluations
$200+ 88
$100-199 53
$50-99 139
$25-49 166
< $25 334
Not specified 348

What people switch to and from

Patients started taking Modafinil after stopping:

Treatment Patients
Methylphenidate (Ritalin) 27
Armodafinil (Nuvigil) 19
Amphetamine-Dextroamphetamine (Adderall) 17
Amantadine (Symmetrel) 10
Pemoline 2

Show all 17 treatments patients report switching from

Patients stopped taking Modafinil and switched to:

Treatment Patients
Armodafinil (Nuvigil) 34
Amphetamine-Dextroamphetamine (Adderall) 26
Methylphenidate (Ritalin) 9
Dextroamphetamine (Dexedrine) 4
Amantadine (Symmetrel) 2

Show all 9 treatments patients report switching to

Last updated:

133 patient evaluations for Modafinil

Jan 28, 2016 (Started Jan 07, 2014)

  • Effectiveness
    Moderate (for excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: I talked to Dr. O about me still being so tired all of the time and he increased my dosage to 400 mg a day. Hopefully that will help. I don't know if my CFS has gotten worse, I have Winter Sun Deprivation, or I am building up a tolerance to the Provigil. I hope it is not the third choice. Wish me luck folks at the new dosage. Today it really didn't wake me up as I really wanted to take a nap today but I was able to resist the urge which was an improvement I guess. :)
Cost: < $25 monthly

Nov 21, 2015 (Started Jan 07, 2014)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Side effects
    Mild (decreased appetite)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: On my last visit with Dr. O I asked him to increase my Provigil so he upped me to 300mg a day. I thought that 200mg was max but he told me to break one in half. That is okay with me. They don't taste bad. I really needed my dose adjusted as I was starting to lose the benefits of the medicine. Since September I have been getting up every day but some days have been a real struggle for me. I don't want to sleep my day away. My depression has also lifted from my MIL passing away and that helps to get me out of bed. Abilify helped with that too. Depression on top of CFS really put me down for awhile. The increase to 300mg is making a difference in how I am feeling. I hope that the feelings continue at least for awhile and I don't become accustomed to this dose too soon. My appetite is still down so I can pretty much eat whatever I want to because I am down to my ideal weight. That was certainly an unexpected benefit!!!
Cost: < $25 monthly

Sep 21, 2015 (Started Jan 07, 2014)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 200 mg Daily
Advice & Tips: I try to take the Provigil every day but some days my fatigue is so terrible that I forget that I even have the Provigil even though I have been taking it for over a year and a half. I will be surprised when I realize that I have forgotten that I even have it and I have stayed a day or two in bed, unable to get up. I have thought about bringing the Provigil into my bedroom so that I never have to get out of bed to take it. I did talk to Dr. O who rx's the Provigil and asked him to think about upping my dose to 250mg a day (this is the maximum dose) as some other days I will take the Provigil and then lay back down and fall back to sleep and sleep through some of the day and this is not what the Provigil is supposed to do. It is supposed to prevent this. I still say though that Provigil has changed my life by giving me the ability to stay awake and one of the added benefits is that it has helped me to lose the last of the weight that the Lyrica put on me. I am glad to lose the last of that weight as it was so hard for me to get around. I am thankful every day for the Provigil!!!
Cost: < $25 monthly

Apr 17, 2014 (Started Jan 07, 2014)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: I take the Provigil with my morning meds and it has made a significant improvement in my daytime fatigue. I have benefited from feeling mentally alert and able to function better. I feel as if some of the weight has been lifted off of my shoulders. I did not notice a real change until after the 4th week.
Cost: < $25 monthly

  • 0 helpful marks

Jan 26, 2016 (Started Oct 14, 2005)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Effectiveness
    Major (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: Provigil remains my fantastic life changer, since it keeps me awake all day.
Cost: < $25 monthly

Apr 28, 2015 (Started Oct 14, 2005)

  • Effectiveness
    None (for multiple sclerosis)
  • Effectiveness
    Major (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: Provigil continues to be a very effective treatment for fatigue, I would not be able to stay awake without it.
Cost: < $25 monthly

Jan 25, 2012 (Started Oct 14, 2005)

  • Effectiveness
    Major (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: The increased dosage helps to shorten how long I sleep, when I sometimes still fall asleep during the day. I also don't fall back to sleep, right after eating breakfast or lunch.
Cost: < $25 monthly

Jul 19, 2009 (Started Oct 14, 2005)

  • Effectiveness
    Major (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Cost: < $25 monthly

Nov 7, 2008 (Started Oct 14, 2005)

  • Effectiveness
    Major (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Provigil has enabled me to stay awake and function all day, without it I fall asleep when I am sitting down longer than 15 minutes. I am still able to nap or rest, even if I just took it and it does not make me nervous or jittery.
Cost: $200+ monthly

  • 1 helpful mark

Jan 15, 2016 (Started Jan 01, 2010)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 3 of 133 patient evaluations for Modafinil