What is Modafinil?

Category: Prescription Drugs

Most popular types: Provigil Alertec Modiodal Show all

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Modafinil is stimulant used to improve wakefulness in patients narcolepsy and shift work sleep disorder or as an adjunctive therapy for obstructive sleep apnea. It may also be used for attention-deficit/hyperactivity disorder and to treat fatigue in MS and other disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fatigue 1,534 721
Multiple sclerosis 917 437
Excessive daytime sleepiness (somnolence) 526 367
Narcolepsy 106 57
Brain fog 81 53

Show all 85 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 73
Moderate 157
Mild 262
None 646

Commonly reported side effects and conditions associated with Modafinil

Side effect Patients
Jittery feeling 59
Headaches 56
Dry mouth 51
Anxious mood 36
Tachycardia (fast heart rate) 31
Irritability 22

Show all 148 reported side effects

Dosages

Based on patients currently taking Modafinil

Dosage Patients
200 mg daily 86
100 mg daily 55
400 mg daily 30
200 mg twice daily 18
200mg as needed 10
100 mg twice daily 7
100mg as needed 6
400 mg twice daily 5
150 mg daily 4
300 mg daily 3

See all 29 dosages

Why patients stopped taking Modafinil

Multiple reasons could be selected

Reason Patients
Did not seem to work 291
Other 207
Side effects too severe 200
Expense 182
Doctor's advice 118
Change in health plan coverage 93
Personal research 36
Course of treatment ended 19
See all 887 patients who've stopped taking Modafinil

Duration

Currently taking Modafinil

Duration Patients
Less than 1 month 1
1 - 6 months 13
6 months - 1 year 9
1 - 2 years 14
2 - 5 years 51
5 - 10 years 83
10 years or more 74

Stopped taking Modafinil

Duration Patients
Less than 1 month 132
1 - 6 months 184
6 months - 1 year 128
1 - 2 years 145
2 - 5 years 197
5 - 10 years 78
10 years or more 26
Adherence
Adherence Evaluations
Always 775
Usually 228
Sometimes 98
Never taken as prescribed 37
Burden
Burden Evaluations
Very hard to take 36
Somewhat hard to take 65
A little hard to take 143
Not at all hard to take 894
Cost per month
Cost per month Evaluations
$200+ 89
$100-199 54
$50-99 140
$25-49 166
< $25 337
Not specified 352

What people switch to and from

Patients started taking Modafinil after stopping:

Treatment Patients
Methylphenidate (Ritalin) 26
Armodafinil (Nuvigil) 20
Amphetamine-Dextroamphetamine (Adderall) 16
Amantadine (Symmetrel) 11
Dextroamphetamine (Dexedrine) 2

Show all 16 treatments patients report switching from

Patients stopped taking Modafinil and switched to:

Treatment Patients
Armodafinil (Nuvigil) 33
Amphetamine-Dextroamphetamine (Adderall) 29
Methylphenidate (Ritalin) 10
Dextroamphetamine (Dexedrine) 4
Amantadine (Symmetrel) 2

Show all 9 treatments patients report switching to

Last updated:

133 patient evaluations for Modafinil

Apr 20, 2009 (Started Apr 16, 2009)

  • Effectiveness
    Moderate (for excessive daytime sleepiness (somnolence))
  • Side effects
    Moderate (stiffness in neck, irritability, headaches, dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: Do not take too close to bedtime - or you will not sleep. Does give some help with daytime drowsiness.
Cost: < $25 monthly
Side effects: dry mouth, irritability, headaches, stiffness in neck

  • 2 helpful marks

Apr 24, 2009 (Started Nov 01, 2005)

  • Effectiveness
    Moderate (for fatigue)
  • Side effects
    Severe (sleep problems, stiffness in neck, jittery feeling, irritability, dry mouth, anxious mood)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 100 mg Daily
Advice & Tips: take if you need it and leave it alone if you don't
Cost: $50-99 monthly
Side effects: dry mouth, jittery feeling, sleep problems, anxious mood, irritability, stiffness in neck

  • 2 helpful marks

May 26, 2011 (Started Jul 18, 2009)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Effectiveness
    Moderate (for obstructive sleep apnea)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: Got my life back. When combined with SSRI's was by far the best treatment for depression I have ever seen. It should be considered for trials for depression.....
Cost: $25-49 monthly
Side effects: hot flashes

Jun 19, 2010 (Started Jul 18, 2009)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Effectiveness
    Major (for obstructive sleep apnea)
  • Side effects
    Mild (hot flashes)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: Life with out Modafinil is very ordinary. I was first diagnosed with depression two year before having a sleep study and OSA and somnolence was discovered. I wonder now if the depression was just a result of these two conditions. I am on 150mg of Setraline for the depression and since being on both that and 200mg of modafinil, I have my life back. I once could not walk past the bed and not want to get in. I often fell aslep if I lay down on the floor to play with my children. I was a zombie. Great drug. Worth every cent for my issues.
Cost: $25-49 monthly
Side effects: hot flashes

  • 2 helpful marks
Last updated:
Showing 3 of 133 patient evaluations for Modafinil