What is Modafinil?

Category: Prescription Drugs

Most popular types: Provigil Alertec Modiodal Show all

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Modafinil is stimulant used to improve wakefulness in patients narcolepsy and shift work sleep disorder or as an adjunctive therapy for obstructive sleep apnea. It may also be used for attention-deficit/hyperactivity disorder and to treat fatigue in MS and other disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fatigue 1,515 689
Multiple sclerosis 920 427
Excessive daytime sleepiness (somnolence) 502 342
Narcolepsy 101 54
Brain fog 80 49

Show all 93 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
72
Moderate
155
Mild
254
None
613

Commonly reported side effects and conditions associated with Modafinil

Side effect Patients
Jittery feeling 58
Headaches 56
Dry mouth 51
Anxious mood 36
Sleep problems 29
Heart rate increased 26

Show all 178 reported side effects

Dosages

Based on patients currently taking Modafinil

Dosage Patients
200 mg daily 98
100 mg daily 57
400 mg daily 29
200 mg twice daily 19
200mg as needed 12
100mg as needed 10
100 mg twice daily 5
400 mg twice daily 4
50 mg daily 3
150 mg daily 2

See all 27 dosages

Why patients stopped taking Modafinil

Multiple reasons could be selected

Reason Patients
Did not seem to work 281
Other 204
Side effects too severe 197
Expense 182
Doctor's advice 119
Change in health plan coverage 89
Personal research 35
Course of treatment ended 19
See all 871 patients who've stopped taking Modafinil

Duration

Currently taking Modafinil

Duration Patients
Less than 1 month 1
1 - 6 months 15
6 months - 1 year 12
1 - 2 years 24
2 - 5 years 42
5 - 10 years 103
10 years or more 63

Stopped taking Modafinil

Duration Patients
Less than 1 month 120
1 - 6 months 186
6 months - 1 year 128
1 - 2 years 145
2 - 5 years 193
5 - 10 years 76
10 years or more 26
Adherence
Adherence Evaluations
Always 743
Usually 219
Sometimes 96
Never taken as prescribed 36
Burden
Burden Evaluations
Very hard to take 36
Somewhat hard to take 64
A little hard to take 138
Not at all hard to take 856
Cost per month
Cost per month Evaluations
$200+ 88
$100-199 51
$50-99 135
$25-49 159
< $25 322
Not specified 339

What people switch to and from

Patients started taking Modafinil after stopping:

Treatment Patients
Methylphenidate (Ritalin) 25
Amphetamine-Dextroamphetamine (Adderall) 16
Armodafinil (Nuvigil) 14
Amantadine (Symmetrel) 9
Bupropion (Wellbutrin XL) 2

Show all 18 treatments patients report switching from

Patients stopped taking Modafinil and switched to:

Treatment Patients
Armodafinil (Nuvigil) 27
Amphetamine-Dextroamphetamine (Adderall) 26
Methylphenidate (Ritalin) 10
Dextroamphetamine (Dexedrine) 4
Amantadine (Symmetrel) 2

Show all 8 treatments patients report switching to

Last updated:

131 patient evaluations for Modafinil

Apr 24, 2009 (Started Nov 01, 2005)

  • Effectiveness
    Moderate (for fatigue)
  • Side effects
    Severe (sleep problems, stiffness in neck, jittery feeling, irritability, dry mouth, anxious mood)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 100 mg Daily
Advice & Tips: take if you need it and leave it alone if you don't
Cost: $50-99 monthly
Side effects: dry mouth, jittery feeling, sleep problems, anxious mood, irritability, stiffness in neck

  • 2 helpful marks

May 26, 2011 (Started Jul 18, 2009)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Effectiveness
    Moderate (for obstructive sleep apnea)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: Got my life back. When combined with SSRI's was by far the best treatment for depression I have ever seen. It should be considered for trials for depression.....
Cost: $25-49 monthly
Side effects: hot flashes

Jun 19, 2010 (Started Jul 18, 2009)

  • Effectiveness
    Major (for excessive daytime sleepiness (somnolence))
  • Effectiveness
    Major (for obstructive sleep apnea)
  • Side effects
    Mild (hot flashes)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: Life with out Modafinil is very ordinary. I was first diagnosed with depression two year before having a sleep study and OSA and somnolence was discovered. I wonder now if the depression was just a result of these two conditions. I am on 150mg of Setraline for the depression and since being on both that and 200mg of modafinil, I have my life back. I once could not walk past the bed and not want to get in. I often fell aslep if I lay down on the floor to play with my children. I was a zombie. Great drug. Worth every cent for my issues.
Cost: $25-49 monthly
Side effects: hot flashes

  • 2 helpful marks

Mar 31, 2013 (Started Jul 28, 2010)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Effectiveness
    Moderate (for brain fog)
  • Effectiveness
    Moderate (for cognitive impairment)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily

Jul 28, 2010 (Started Jul 28, 2010)

  • Effectiveness
    Moderate (for brain fog)
  • Effectiveness
    Moderate (for cognitive impairment)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: If I should miss taking this for some reason in the morning I can tell by early evening that I didn't take it. My medications are set up once a week to be taken daily 3 times a day so I won't forget to take them.
Cost: < $25 monthly

  • 2 helpful marks
Last updated:
Showing 3 of 131 patient evaluations for Modafinil