What is Modafinil?

Category: Prescription Drugs

Most popular types: Provigil Alertec Modiodal Show all

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Modafinil is stimulant used to improve wakefulness in patients narcolepsy and shift work sleep disorder or as an adjunctive therapy for obstructive sleep apnea. It may also be used for attention-deficit/hyperactivity disorder and to treat fatigue in MS and other disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fatigue 1,492 652
Multiple Sclerosis 915 403
Excessive daytime sleepiness (somnolence) 481 313
Brain fog 82 49
Narcolepsy 75 40
Cognitive impairment 35 17

Show all 96 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 65
Moderate 150
Mild 235
None 553

Commonly reported side effects and conditions associated with Modafinil

Side effect Patients
Jittery feeling 57
Dry mouth 51
Headaches 50
Anxious mood 35
Sleep problems 29
Heart rate increased 25

Show all 167 reported side effects

Dosages

Based on patients currently taking Modafinil

Dosage Patients
200 mg daily 71
100 mg daily 42
400 mg daily 22
200 mg twice daily 9
100mg as needed 6
400 mg twice daily 5
100 mg twice daily 4
50 mg daily 3
200mg as needed 3
150 mg daily 2

See all 25 dosages

Why patients stopped taking Modafinil

Multiple reasons could be selected

Reason Patients
Did not seem to work 270
Other 195
Side effects too severe 190
Expense 179
Doctor's advice 112
Change in health plan coverage 85
Personal research 33
Course of treatment ended 19
See all 838 patients who’ve stopped taking Modafinil

Duration

Currently taking Modafinil

Duration Patients
Less than 1 month 1
1 - 6 months 8
6 months - 1 year 11
1 - 2 years 17
2 - 5 years 34
5 - 10 years 76
10 years or more 37

Stopped taking Modafinil

Duration Patients
Less than 1 month 118
1 - 6 months 179
6 months - 1 year 118
1 - 2 years 139
2 - 5 years 189
5 - 10 years 75
10 years or more 22
Adherence
Adherence Evaluations
Always 677
Usually 208
Sometimes 89
Never taken as prescribed 29
Burden
Burden Evaluations
Very hard to take 32
Somewhat hard to take 57
A little hard to take 134
Not at all hard to take 780
Cost per month
Cost per month Evaluations
$200+ 82
$100-199 46
$50-99 125
$25-49 154
< $25 285
Not specified 311

What people switch to and from

Patients started taking Modafinil after stopping:

Treatment Patients
Methylphenidate (Ritalin) 13
Amphetamine-Dextroamphetamine (Adderall) 8
Armodafinil (Nuvigil) 8
Amantadine (Symmetrel) 7
Amitriptyline (Elavil) 1

Show all 12 treatments patients report switching from

Patients stopped taking Modafinil and switched to:

Treatment Patients
Armodafinil (Nuvigil) 21
Amphetamine-Dextroamphetamine (Adderall) 15
Methylphenidate (Ritalin) 3
Amantadine (Symmetrel) 1
Dextroamphetamine (Dexedrine) 1

Show all 7 treatments patients report switching to

Last updated:

131 patient evaluations for Modafinil

726 members have decided to share their profiles only with other members of PatientsLikeMe.

Tulabee
14440 thumb
Tulabee
Sex: F
Data Quality: 2 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See Tulabee's full Modafinil history

Sep 23, 2016 (Started Sep 01, 2009)

  • Effectiveness
    Can’t tell (for Excessive daytime sleepiness (somnolence))
  • Side effects
    Mild (Insomnia)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: I am starting at 100mg/day. Maybe the Rytary helps with wakefulness? Must wait until the dead of winter.
Cost: < $25 monthly

Feb 1, 2015 (Started Sep 01, 2009)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    Mild (Insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: I take 300mg/day.
Cost: < $25 monthly

Nov 8, 2014 (Started Sep 01, 2009)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    Mild (Insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Started on Nov 1. 2014 this season. 300mg modafinil. Yes, I n case I start to doubt if the drug is helpful--it is. Caffeine does not help me feel better. More sleep does not help me feel more lively.
Cost: < $25 monthly

Feb 22, 2014 (Started Sep 01, 2009)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    Mild (Insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: I have been take this seasonally. Note that the "plan" price at Express Scripts was about $1000 for 90 day supply (any dosage); my insurance price was about $100. Now, my insurance price for the same 90 day supply is $20 and I think it's because of generic/patent status.
Cost: < $25 monthly

Apr 18, 2013 (Started Sep 01, 2009)

  • Effectiveness
    Moderate (for Excessive daytime sleepiness (somnolence))
  • Side effects
    Moderate (Insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: I still take this in the fall (when the days are just starting to get short) like the end of August. I then stop in March. I have used Nuvigil or Provigil. If I decrease dose, i am sleepy during day. If i maintain does, it is very easy to stay up until 1am.
Cost: $25-49 monthly

Aug 23, 2011 (Started Sep 01, 2009)

  • Effectiveness
    Moderate (for Excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: Helps with sleepiness during the day.
Cost: $25-49 monthly

May 13, 2010 (Started Sep 01, 2009)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I liked Provigil. It counteracted the sleepiness from Cymbalta prescribed by the psychatrist, but the dosage wasn't enough for sleepiness from Mirapex prescribed by the neurologist. Medco wouldn't up my dosage.
Cost: $25-49 monthly

May 2, 2010 (Started Sep 01, 2009)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: This works. My Rx ran out, then Medco wouldn't allow me300mg/day. then the dr. subscribes a new drug Nuvigil for250g/day. Note that Provigil will go generic soon, and the cost will decrease.
Cost: $25-49 monthly

  • 0 helpful marks
Keeper of the Flame
10493 thumb
Keeper of the Flame
Gender: F
Data Quality: 3 stars
Pain: Some
Fatigue: Some
Sleep: Most
Stiffness: Some
function: Some
external_stress: Little
Stickman: some
Description:F58y
CFS:?y
FM:8y Dx
I am: b
I have:
Fibromyalgia

See Keeper of the Flame's full Modafinil history

Jan 28, 2016 (Started Jan 07, 2014)

  • Effectiveness
    Moderate (for Excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: I talked to Dr. O about me still being so tired all of the time and he increased my dosage to 400 mg a day. Hopefully that will help. I don't know if my CFS has gotten worse, I have Winter Sun Deprivation, or I am building up a tolerance to the Provigil. I hope it is not the third choice. Wish me luck folks at the new dosage. Today it really didn't wake me up as I really wanted to take a nap today but I was able to resist the urge which was an improvement I guess. :)
Cost: < $25 monthly

Nov 21, 2015 (Started Jan 07, 2014)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    Mild (Loss of appetite)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: On my last visit with Dr. O I asked him to increase my Provigil so he upped me to 300mg a day. I thought that 200mg was max but he told me to break one in half. That is okay with me. They don't taste bad. I really needed my dose adjusted as I was starting to lose the benefits of the medicine. Since September I have been getting up every day but some days have been a real struggle for me. I don't want to sleep my day away. My depression has also lifted from my MIL passing away and that helps to get me out of bed. Abilify helped with that too. Depression on top of CFS really put me down for awhile. The increase to 300mg is making a difference in how I am feeling. I hope that the feelings continue at least for awhile and I don't become accustomed to this dose too soon. My appetite is still down so I can pretty much eat whatever I want to because I am down to my ideal weight. That was certainly an unexpected benefit!!!
Cost: < $25 monthly

Sep 21, 2015 (Started Jan 07, 2014)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 200 mg Daily
Advice & Tips: I try to take the Provigil every day but some days my fatigue is so terrible that I forget that I even have the Provigil even though I have been taking it for over a year and a half. I will be surprised when I realize that I have forgotten that I even have it and I have stayed a day or two in bed, unable to get up. I have thought about bringing the Provigil into my bedroom so that I never have to get out of bed to take it. I did talk to Dr. O who rx's the Provigil and asked him to think about upping my dose to 250mg a day (this is the maximum dose) as some other days I will take the Provigil and then lay back down and fall back to sleep and sleep through some of the day and this is not what the Provigil is supposed to do. It is supposed to prevent this. I still say though that Provigil has changed my life by giving me the ability to stay awake and one of the added benefits is that it has helped me to lose the last of the weight that the Lyrica put on me. I am glad to lose the last of that weight as it was so hard for me to get around. I am thankful every day for the Provigil!!!
Cost: < $25 monthly

Apr 17, 2014 (Started Jan 07, 2014)

  • Effectiveness
    Major (for Excessive daytime sleepiness (somnolence))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: I take the Provigil with my morning meds and it has made a significant improvement in my daytime fatigue. I have benefited from feeling mentally alert and able to function better. I feel as if some of the weight has been lifted off of my shoulders. I did not notice a real change until after the 4th week.
Cost: < $25 monthly

  • 0 helpful marks
thjuland
647 thumb
thjuland
Sex: M
Data Quality: 3 stars
Sensation: Mild
Overall: Mild
Cognition: moderate
Vision: moderate
Speech: mild
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: vg
I have:
MS

See thjuland's full Modafinil history

Jan 26, 2016 (Started Oct 14, 2005)

  • Effectiveness
    Moderate (for Multiple Sclerosis)
  • Effectiveness
    Major (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: Provigil remains my fantastic life changer, since it keeps me awake all day.
Cost: < $25 monthly

Apr 28, 2015 (Started Oct 14, 2005)

  • Effectiveness
    None (for Multiple Sclerosis)
  • Effectiveness
    Major (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: Provigil continues to be a very effective treatment for fatigue, I would not be able to stay awake without it.
Cost: < $25 monthly

Jan 25, 2012 (Started Oct 14, 2005)

  • Effectiveness
    Major (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: The increased dosage helps to shorten how long I sleep, when I sometimes still fall asleep during the day. I also don't fall back to sleep, right after eating breakfast or lunch.
Cost: < $25 monthly

Jul 19, 2009 (Started Oct 14, 2005)

  • Effectiveness
    Major (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Cost: < $25 monthly

Nov 7, 2008 (Started Oct 14, 2005)

  • Effectiveness
    Major (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Provigil has enabled me to stay awake and function all day, without it I fall asleep when I am sitting down longer than 15 minutes. I am still able to nap or rest, even if I just took it and it does not make me nervous or jittery.
Cost: $200+ monthly

  • 1 helpful mark
Last updated:
Showing 3 of 131 patient evaluations for Modafinil