What is Memantine?

Category: Prescription Drugs

Most popular types: Namenda Namenda XR Ebixa Show all

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Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system. It is also being tested for use as a cognitive enhancer in a variety of other conditions.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Cognitive impairment 34 16
Memory problems 23 14
Amyotrophic lateral sclerosis 22 6
Brain fog 12 6
Migraine headaches 9 4
Fibromyalgia 7 5

Show all 50 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 3
Moderate 7
Mild 10
None 44

Commonly reported side effects and conditions associated with Memantine

Side effect Patients
Ataxia (lack of coordination) 1
Balance problems 1
Brain fog 1
Constipation 1
Difficulty urinating (dysuria) 1
Dizziness 1

Show all 15 reported side effects

Dosages

Based on patients currently taking Memantine

Dosage Patients
10 mg twice daily 7
5 mg twice daily 5
20 mg daily 4
5 mg daily 3
28 mg daily 3
10 mg daily 2
2 mg daily 1
15 mg daily 1
20 mg twice daily 1

Why patients stopped taking Memantine

Multiple reasons could be selected

Reason Patients
Did not seem to work 18
Doctor's advice 10
Side effects too severe 9
Expense 5
Other 3
Change in health plan coverage 2
Personal research 1
See all 36 patients who've stopped taking Memantine

Duration

Currently taking Memantine

Duration Patients
1 - 6 months 2
6 months - 1 year 2
1 - 2 years 5
2 - 5 years 7
5 - 10 years 6
10 years or more 5

Stopped taking Memantine

Duration Patients
Less than 1 month 9
1 - 6 months 7
6 months - 1 year 4
1 - 2 years 7
2 - 5 years 6
5 - 10 years 2
10 years or more 1
Adherence
Adherence Evaluations
Always 55
Usually 6
Sometimes 1
Never taken as prescribed 2
Burden
Burden Evaluations
Very hard to take 2
Somewhat hard to take 4
A little hard to take 10
Not at all hard to take 48
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 4
$50-99 12
$25-49 22
< $25 4
Not specified 21

What people switch to and from

Patients started taking Memantine after stopping:

Treatment Patients
Pregabalin (Lyrica) 2
Amantadine (Symmetrel) 1
Butalbital-acetaminophen-caffeine (Fioricet) 1
Duloxetine (Cymbalta) 1
Levetiracetam (Keppra) 1

Show all 8 treatments patients report switching from

Patients stopped taking Memantine and switched to:

Treatment Patients
Candesartan (Atacand) 1
Memantine (Namenda) 1
Last updated:

7 patient evaluations for Memantine

May 11, 2010 (Started Dec 07, 2009)

  • Effectiveness
    Moderate (for amphetamine tolerance)
  • Effectiveness
    Moderate (for obsessive-compulsive disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Mild
  • Adherence
    Sometimes
  • Burden
    A little hard to take
Dosage: 15 mg Daily
Cost: $25-49 monthly

Mar 26, 2010 (Started Dec 07, 2009)

  • Effectiveness
    Major (for amphetamine tolerance)
  • Effectiveness
    Major (for obsessive-compulsive disorder)
  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Advice & Tips: --titrate dose up slowly, starting at 5mg for 3-15 days before going up to 10mg. Acute side effects, such as "brain fog", confusion, memory loss, body aches, ect....are at their worst for the first 2-4 days after starting new/raising dose. Apparently, most people report the side effects to become unbothersome at 1-2 weeks, and after 4 weeks, side effects such as memory loss/brain fog/confusion are completely gone. After 2-4 weeks, an improvement (as opposed to a decrease) in attention, cognition, and memory abilities is commonly noticed --- hence, Memantine's clinical benefit in Alzheimer's disease patients. Memantine is not an "Alzheimers Disease Medication/Drug". It is a mixed (non-selective) NMDA, 5-HT3, and Nicotinic Acetylcholine receptor antagonist. These three mechanisms significantly modulate attention, memory, cognition, and many other aspects of mental function....the use of Memantine in Alzheimers disease is merely due to the discovery that chronic Memantine improves memory in such patients. Other uses of Memantine include: preventing Amphetamine/Opiate tolerance, OCD/Obsessive Compulsive Disorder, ADD/ADHD, and others.
Cost: $25-49 monthly

  • 1 helpful mark

Nov 7, 2009 (Started )

  • Effectiveness
    Major (for amyotrophic lateral sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Advice & Tips: has slowed progression and significantly decreased my shortness of breath through out the day, which in turn has increased my energy level. best med yet
Cost: $25-49 monthly

  • 0 helpful marks

Jan 1, 2009 (Started Jan 01, 2003)

  • Effectiveness
    Can't tell (for Preserve memory)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Advice & Tips: Very easy to take, no adverse side effects. It didn't cause nausea like Aricept did for several weeks (it did subside). My neurologist found some info on possible adverse indications from taking it and encouraged me to stop so I did reluctantly.

  • 0 helpful marks
Last updated:
Showing 3 of 7 patient evaluations for Memantine