What is 5-Hydroxytryptophan (5-HTP)?

Category: Supplements

Most popular types: 5 HTP TR Natrol 5-HTP NOW 5-HTP Show all

false

See also: 5-hydroxytryptophan and L-Theanine Endo Plus

5-Hydroxytryptophan or 5-HTP is a naturally-occurring amino acid marketed in the United States and other countries as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Depressed mood 59 35
Fibromyalgia 50 38
Insomnia 38 27
Major depressive disorder 16 17
Amyotrophic lateral sclerosis 14 6

Show all 73 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 6
Moderate 9
Mild 18
None 100

Commonly reported side effects and conditions associated with 5-Hydroxytryptophan (5-HTP)

Side effect Patients
Nausea 3
Heart palpitations 2
Irritability 2
Vivid dreams 2
Agitation 1
Bipolar manic episodes 1

Show all 23 reported side effects

Dosages

Based on patients currently taking 5-Hydroxytryptophan (5-HTP)

Dosage Patients
200 mg daily 9
100 mg daily 6
50 mg daily 4
1 other daily 1
2 mg daily 1
13 mg daily 1
400 mg daily 1

Why patients stopped taking 5-Hydroxytryptophan (5-HTP)

Multiple reasons could be selected

Reason Patients
Did not seem to work 38
Other 30
Expense 13
Side effects too severe 10
Course of treatment ended 9
Doctor's advice 9
Personal research 4
Change in health plan coverage 1
See all 94 patients who've stopped taking 5-Hydroxytryptophan (5-HTP)

Duration

Currently taking 5-Hydroxytryptophan (5-HTP)

Duration Patients
1 - 6 months 4
1 - 2 years 6
2 - 5 years 7
5 - 10 years 6
10 years or more 1

Stopped taking 5-Hydroxytryptophan (5-HTP)

Duration Patients
Less than 1 month 20
1 - 6 months 38
6 months - 1 year 17
1 - 2 years 10
2 - 5 years 7
5 - 10 years 2
10 years or more 1
Adherence
Adherence Evaluations
Always 79
Usually 34
Sometimes 17
Never taken as prescribed 3
Burden
Burden Evaluations
Very hard to take 1
Somewhat hard to take 10
A little hard to take 19
Not at all hard to take 103
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 0
$50-99 3
$25-49 19
< $25 74
Not specified 36
Last updated:

14 patient evaluations for 5-Hydroxytryptophan (5-HTP)

May 6, 2017 (Started Sep 15, 2016)

  • Effectiveness
    Major (for gastrointestinal dysmotility)
  • Side effects
    Mild (hot flash after eating, flushing)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: 5-HTP is a serotonin precursor. Serotonin is well-known as a hormone that affects one's mood in a positive way, but it is probably less-well known that it increases intestinal motility. It has worked magic for my symptoms. I am completely regular now, and the majority of my days are good days, whereas before I began taking it the majority of my days were bad days that began with symptoms of constipation and intestinal pain or discomfort. For me, at least, this is not a prescription. I began taking 5-HTP after my fiancee'--who had already been taking it to help her mood and, primarily, her difficulty sleeping through the night--learned it can be helpful when taken for gastrointestinal motility, and I began taking it myself shortly after that (and felt its effects almost immediately). Although not entirely unexpected, my slightly enhanced good moods are a nice side benefit of taking the supplement. I do get some very mild undesirable side effects, especially during mid-day when I take twice my morning and evening dose of 100 mg. Sometimes my face feels hot and flushes fairly noticeably--and this may be intensified with eating--but those symptoms subside within probably 30 minutes or less.
Cost: < $25 monthly

  • 1 helpful mark

Dec 18, 2016 (Started Dec 08, 2012)

  • Effectiveness
    Slight (for sleep problems)
  • Effectiveness
    Slight (for problems concentrating)
  • Effectiveness
    Slight (for major depressive disorder)
  • Effectiveness
    Moderate (for difficulty falling asleep)
  • Effectiveness
    Slight (for depressed mood)
  • Effectiveness
    Slight (for borderline personality disorder)
  • Effectiveness
    Moderate (for anxious mood)
  • Side effects
    Moderate (vivid dreams)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: Wasn't sure if this was making my depression a lot worse. I also was having very vivid dreams
Cost: < $25 monthly

Apr 2, 2016 (Started Dec 08, 2012)

  • Effectiveness
    Moderate (for sleep problems)
  • Effectiveness
    Slight (for problems concentrating)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Major (for difficulty falling asleep)
  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Slight (for borderline personality disorder)
  • Effectiveness
    Slight (for anxious mood)
  • Side effects
    Mild (vivid dreams)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips:  I feel like it really makes a difference the next day after I take this, especially when my depression gets really bad. I decided to stop taking it while I was on my mediation retreat because I wanted to see if there was a difference.
Cost: < $25 monthly

Aug 10, 2015 (Started Dec 08, 2012)

  • Effectiveness
    Moderate (for difficulty falling asleep)
  • Effectiveness
    Slight (for depressed mood)
  • Effectiveness
    Slight (for borderline personality disorder)
  • Effectiveness
    Slight (for anxious mood)
  • Side effects
    Mild (vivid dreams)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly

Apr 1, 2014 (Started Dec 08, 2012)

  • Effectiveness
    Can't tell (for borderline personality disorder)
  • Effectiveness
    Slight (for anxious mood)
  • Effectiveness
    Can't tell (for depressed mood)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: Not really sure if it is working, I don't really feel the need to take this at the moment, so I am just going to stick to Valerian root a couple times a week as needed
Cost: < $25 monthly

Mar 8, 2013 (Started Dec 08, 2012)

  • Effectiveness
    Slight (for borderline personality disorder)
  • Effectiveness
    Slight (for anxious mood)
  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: Made me feel just a little bit better, so I felt I could get through the day. Just a little tiny boost
Cost: < $25 monthly

  • 0 helpful marks

Oct 5, 2016 (Started Jul 05, 2016)

  • Effectiveness
    Can't tell (for amyotrophic lateral sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 14 patient evaluations for 5-Hydroxytryptophan (5-HTP)