What is Rituximab?

Category: Prescription Drugs

Most popular types: Rituxan Mabthera

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See also: DRC protocol FCMR protocol ILD Phase II/III Rituximab Versus Cyclophosphamide RECITAL Study R-CVP protocol RT protocol

Rituximab is a medication in a class of medications called monoclonal antibodies and given by infusion. It is used in the treatment of non-Hodgkins lymphoma and also in the treatment of rheumatoid arthritis.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 114 75
Rheumatoid arthritis 94 48
Neuromyelitis optica 60 36
Systemic lupus erythematosus 21 9
Chronic lymphocytic leukemia 18 9

Show all 83 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 33
Moderate 38
Mild 74
None 81

Commonly reported side effects and conditions associated with Rituximab

Side effect Patients
Fatigue 31
Nausea 22
Headaches 10
Tiredness 6
Hair loss 5
Decreased appetite 4

Show all 101 reported side effects

Dosages

Based on patients currently taking Rituximab

Dosage Patients
10 mg every 6 months 13
1,000 mg every 6 months 6
500 mg every 6 months 5
1 other every 6 months 3
20 mg every 6 months 3
10 mg every 3 months 2
10 mg every 12 weeks 2
1,000 mg every 3 months 2
100 mg every 6 months 2
2 g yearly 1

See all 33 dosages

Why patients stopped taking Rituximab

Multiple reasons could be selected

Reason Patients
Course of treatment ended 58
Did not seem to work 40
Doctor's advice 30
Side effects too severe 27
Other 21
Change in health plan coverage 5
Expense 4
Personal research 3
See all 160 patients who've stopped taking Rituximab

Duration

Currently taking Rituximab

Duration Patients
1 - 6 months 6
6 months - 1 year 5
1 - 2 years 12
2 - 5 years 28
5 - 10 years 11
10 years or more 6

Stopped taking Rituximab

Duration Patients
Less than 1 month 64
1 - 6 months 31
6 months - 1 year 20
1 - 2 years 18
2 - 5 years 24
5 - 10 years 2
10 years or more 1
Adherence
Adherence Evaluations
Always 199
Usually 8
Sometimes 5
Never taken as prescribed 14
Burden
Burden Evaluations
Very hard to take 20
Somewhat hard to take 68
A little hard to take 71
Not at all hard to take 67
Cost per month
Cost per month Evaluations
$200+ 36
$100-199 12
$50-99 5
$25-49 4
< $25 67
Not specified 102

What people switch to and from

Patients started taking Rituximab after stopping:

Treatment Patients
Natalizumab (Tysabri) 16
Glatiramer acetate (Copaxone) 11
Fingolimod (Gilenya) 7
Methotrexate (Apo-Methotrexate) 7
Dimethyl fumarate (Tecfidera) 6

Show all 29 treatments patients report switching from

Patients stopped taking Rituximab and switched to:

Treatment Patients
Tocilizumab (Actemra) 5
Natalizumab (Tysabri) 4
Ocrelizumab (Ocrevus) 4
Dimethyl fumarate (Tecfidera) 2
Ibrutinib (Imbruvica) 2

Show all 22 treatments patients report switching to

Last updated:

19 patient evaluations for Rituximab

May 25, 2010 (Started May 22, 2008)

  • Effectiveness
    Major (for neuromyelitis optica)
  • Side effects
    Severe (allergic reaction)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 10000 mg Every 3 months
Advice & Tips: Make sure you are not allergic to the medication. Thought it was just an chronic infusion rxn, when I consulted the allergist, he said I was very allergic to it. Hated to stop the medication as it was very helpful. If you are allergic to guninea pigs/ mice do not take it!
Cost: $200+ monthly
Side effects: allergic reaction

Mar 7, 2010 (Started May 22, 2008)

  • Effectiveness
    Major (for neuromyelitis optica)
  • Side effects
    Moderate (allergic reaction)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 10000 mg Every 3 months
Cost: $100-199 monthly
Side effects: allergic reaction

Mar 5, 2010 (Started May 22, 2008)

  • Effectiveness
    Can't tell (for neuromyelitis optica)
  • Side effects
    Moderate (allergic reaction)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 1000 mg Every 3 months
Advice & Tips: Due to increased severity of pain from the Devic's uncontrolled with the max dose of 200mcg Fentanyl, it was decided that by neurology to do an early dose of Rituxan. In other words, instead of 3 months, we did the Rituxan in 2 months as in the past this has helped with the pain. The infusion was over 24 hours and I had severe issues with hypotension and ventricular arrythmias, needed increased fluid support and keeps the support meds scheduled at every 6 hours (increased the dosages of Benadryl and demerol, tylenol). Will see if the pain improves!
Cost: $100-199 monthly
Side effects: allergic reaction

Feb 28, 2010 (Started May 22, 2008)

  • Effectiveness
    Major (for neuromyelitis optica)
  • Side effects
    Severe (allergic reaction)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 1000 mg Every 3 months
Advice & Tips: This is the only tx that seems to be best though for some reason my relapses try to recur with two months after the infusion. With the other chemo (MTX) I had too many life threatening infections so I had to stop, I will have to deal with the side effects for now. I do feel great for the first two months after the treatment. Usually the tx is done outpatient, but in my case I must stay inpt and the infusion is done between 12-18 hours due to side effects. Need hydration and cardiac monitoring before, during amd after to help deal/ monitor some of the adverse side effects. Myneurologist doesn't understand these increasing adverse reactions with each successive dose. Afraid to increase the frequency for this reason.
Cost: $100-199 monthly
Side effects: allergic reaction

  • 4 helpful marks

Oct 30, 2009 (Started Feb 01, 2009)

  • Effectiveness
    Major (for neuromyelitis optica)
  • Side effects
    Mild (insomnia)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 10 mg Every Other Week
Advice & Tips: Has made me feel alot better; however, I still have symptoms from permanet scare tissue damage. However; after my last two treatments: 1) Feb 2) Oct...both MRI's following each treatment showed significant improvement and no activity and no inflamation. I was and am happy with the results. However, if you are thinking about starting this treatment, it is very important to monitor your B cells through monthly Blood Tests to make sure the medication is doing its job and working.
Side effects: insomnia

  • 1 helpful mark

Dec 31, 2008 (Started May 05, 2005)

  • Effectiveness
    Slight (for Other)
  • Side effects
    Mild (low blood pressure)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 1000 other Yearly
Advice & Tips: In 2005 when I had this treatment it gave me moderate improvement but this time in 2008 I only had slight improvement and that only seemed to last for not quite a full year, unlike the other time which I had some benefit up to 3 years.
Cost: $200+ monthly
Side effects: low blood pressure

  • 1 helpful mark
Last updated:
Showing 3 of 19 patient evaluations for Rituximab