What is Rituximab?

Category: Prescription Drugs

Most popular types: Rituxan Mabthera

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See also: DRC protocol FCMR protocol ILD Phase II/III Rituximab Versus Cyclophosphamide RECITAL Study R-CVP protocol RT protocol

Rituximab is a medication in a class of medications called monoclonal antibodies and given by infusion. It is used in the treatment of non-Hodgkins lymphoma and also in the treatment of rheumatoid arthritis.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 114 75
Rheumatoid arthritis 94 48
Neuromyelitis optica 60 36
Systemic lupus erythematosus 21 9
Chronic lymphocytic leukemia 18 9

Show all 83 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 33
Moderate 38
Mild 74
None 81

Commonly reported side effects and conditions associated with Rituximab

Side effect Patients
Fatigue 31
Nausea 22
Headaches 10
Tiredness 6
Hair loss 5
Decreased appetite 4

Show all 101 reported side effects

Dosages

Based on patients currently taking Rituximab

Dosage Patients
10 mg every 6 months 13
1,000 mg every 6 months 6
500 mg every 6 months 5
1 other every 6 months 3
20 mg every 6 months 3
10 mg every 3 months 2
10 mg every 12 weeks 2
1,000 mg every 3 months 2
100 mg every 6 months 2
2 g yearly 1

See all 33 dosages

Why patients stopped taking Rituximab

Multiple reasons could be selected

Reason Patients
Course of treatment ended 58
Did not seem to work 40
Doctor's advice 30
Side effects too severe 27
Other 21
Change in health plan coverage 5
Expense 4
Personal research 3
See all 160 patients who've stopped taking Rituximab

Duration

Currently taking Rituximab

Duration Patients
1 - 6 months 6
6 months - 1 year 5
1 - 2 years 12
2 - 5 years 28
5 - 10 years 11
10 years or more 6

Stopped taking Rituximab

Duration Patients
Less than 1 month 64
1 - 6 months 31
6 months - 1 year 20
1 - 2 years 18
2 - 5 years 24
5 - 10 years 2
10 years or more 1
Adherence
Adherence Evaluations
Always 199
Usually 8
Sometimes 5
Never taken as prescribed 14
Burden
Burden Evaluations
Very hard to take 20
Somewhat hard to take 68
A little hard to take 71
Not at all hard to take 67
Cost per month
Cost per month Evaluations
$200+ 36
$100-199 12
$50-99 5
$25-49 4
< $25 67
Not specified 102

What people switch to and from

Patients started taking Rituximab after stopping:

Treatment Patients
Natalizumab (Tysabri) 16
Glatiramer acetate (Copaxone) 11
Fingolimod (Gilenya) 7
Methotrexate (Apo-Methotrexate) 7
Dimethyl fumarate (Tecfidera) 6

Show all 29 treatments patients report switching from

Patients stopped taking Rituximab and switched to:

Treatment Patients
Tocilizumab (Actemra) 5
Natalizumab (Tysabri) 4
Ocrelizumab (Ocrevus) 4
Dimethyl fumarate (Tecfidera) 2
Ibrutinib (Imbruvica) 2

Show all 22 treatments patients report switching to

Last updated:

19 patient evaluations for Rituximab

Mar 24, 2016 (Started Feb 25, 2016)

  • Effectiveness
    Can't tell (for transverse myelitis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 10 mg Every 6 months
Advice & Tips: I haven't had any side effects. I cannot tell if there are any unexpected benefits. It takes a full day for me to drive to where my infusion takes place, then drive home. The hospital is 1 1/2 hours one way. The infusion itself takes 6 hours, a week apart. Then the same drive time back home.
Cost: < $25 monthly

  • 0 helpful marks

Sep 15, 2014 (Started Jul 15, 2012)

  • Effectiveness
    Slight (for rheumatoid arthritis)
  • Side effects
    Mild (sinus headaches)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 10 mg Yearly
Advice & Tips: This was an infusion. Go prepared to sit back and relax. Take the Benedryl offered to you and go to sleep for a while. Depending on the dose, you may be there for five hours (or as little as two). Bring a book. No work. No annoying phone calls. This was a perfect excuse to rest. You will havwe to go into the doctor's office and miss a day of work. Immediately after an infusion I would be hungry and tired. So I would go home and take a nap after lunch. Because of small veins and constant dehydration, it would take five to five and a half hours for me to get my dosage. I went once every six months initially, then once every four months. If after three doses you were not getting any relief, talk to your doctor. She may wish to change the number of times you were getting treated.

  • 1 helpful mark

Mar 25, 2013 (Started Mar 15, 2006)

  • Effectiveness
    Major (for systemic lupus erythematosus)
  • Effectiveness
    Major (for rheumatoid arthritis)
  • Side effects
    Moderate (nausea, migraine)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: As needed
Advice & Tips: I use the Scopalamine Patch the night before (helps eliminate the nausea - I have tried Phenergan and Zofran -both used to work, but don't any more). Occasionally I have side effects during the drip (itchiness in throat, ears and head - now they add tagamet and claritin to stop that - last infusion it worked well). Retuxan has changed my life - I was unable to work before i was on it- after the first infusion about 1 month later I went to EUROPE for a week (I never could have gone before!) and I walked, went to Paris, London, had a blast! Prior to retuxan I had stopped working completely and spend most of my life in bed. I had researched this drug and was waiting for for the FDA to approve. As soon as it did my doc got approval ( had been on EVERYTHING prior to that) and had a needle in my arm! I was the second patient to receive treatment at my clinic! It is a godsend! I'm not "normal" but I am a LOT better (I can tell when I can't afford it- it is pricey but the company has started a program to help you pay for what insurance wont (it's apprx 7-20,000 per infusion)So with a copay or if you get it early in the year you owe all of your out of pocked and deductible (3K for me!). It is an all day infusion (about 6 hours) and bc of problems years ago with an insurance company that paid for it, then when we moved to a different insurance company they went back and "retroactively denied treatment" I fought but still owed the clinic $8000 which I did NOT have on hand. They have told me I can NEVER get infused at their clinic (which is a problem bc many clinics are with hospitals and they won't let me get infusioned if my doc doesn't have privs, or the hospitals want the doctor to get approval and her office refuses since they aren't getting paid. SO..advice - even if your doctor says you are approved CALL INSURANCE find out how much you will owe. Once it's in your arm you could owe a lot of money. AND some clinics don't actually get authorization (then they will charge you a LARGE fee - your insurance). BUT apart from the cost (LOL) it is brilliant! OH - the typical dose is 2 infusions 2 weeks apart every 4 months (that is NOT ON THE LIST OF CHOICES). You can get it more frequently (and I did once) but you need to get approval from your insurance.

  • 1 helpful mark
Last updated:
Showing 3 of 19 patient evaluations for Rituximab