What is Divalproex sodium?

Category: Prescription Drugs

Most popular types: Depakote Depakote ER Divalproex ER Show all

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Divalproex sodium is chemically compounded from sodium valproate and valproic acid in a 1:1 ratio. It is a delayed release, enteric coated tablet used for seizures, mania associated with bipolar disorder and prevention of migraines.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Epilepsy 578 271
Bipolar disorder 386 225
Migraine headaches 110 59
Bipolar II disorder 57 37
Bipolar I disorder 49 34
Bipolar manic episodes 45 34

Show all 114 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 183
Moderate 197
Mild 188
None 178

Commonly reported side effects and conditions associated with Divalproex sodium

Side effect Patients
Weight gain 145
Hair loss 46
Fatigue 40
Drowsiness 26
Tremor in hands 21
Nausea 19

Show all 211 reported side effects

Dosages

Based on patients currently taking Divalproex sodium

Dosage Patients
500 mg daily 15
250 mg daily 13
1,000 mg daily 13
250 mg twice daily 11
750 mg daily 11
500 mg twice daily 11
1,500 mg daily 7
2,000 mg daily 7
1,250 mg daily 4
500 mg three times daily 4

See all 28 dosages

Why patients stopped taking Divalproex sodium

Multiple reasons could be selected

Reason Patients
Side effects too severe 349
Did not seem to work 250
Doctor's advice 174
Other 106
Personal research 35
Expense 32
Course of treatment ended 26
Change in health plan coverage 11
See all 645 patients who've stopped taking Divalproex sodium

Duration

Currently taking Divalproex sodium

Duration Patients
1 - 6 months 4
6 months - 1 year 7
1 - 2 years 20
2 - 5 years 28
5 - 10 years 34
10 years or more 30

Stopped taking Divalproex sodium

Duration Patients
Less than 1 month 124
1 - 6 months 143
6 months - 1 year 74
1 - 2 years 79
2 - 5 years 127
5 - 10 years 52
10 years or more 56
Adherence
Adherence Evaluations
Always 586
Usually 115
Sometimes 22
Never taken as prescribed 23
Burden
Burden Evaluations
Very hard to take 56
Somewhat hard to take 119
A little hard to take 118
Not at all hard to take 453
Cost per month
Cost per month Evaluations
$200+ 19
$100-199 19
$50-99 33
$25-49 60
< $25 292
Not specified 323

What people switch to and from

Patients started taking Divalproex sodium after stopping:

Treatment Patients
Lithium Carbonate (Lithium Carbonate ER) 41
Lamotrigine (Lamictal) 20
Topiramate (Topamax) 16
Aripiprazole (Abilify) 10
Quetiapine (Seroquel) 7

Show all 46 treatments patients report switching from

Patients stopped taking Divalproex sodium and switched to:

Treatment Patients
Lamotrigine (Lamictal) 32
Carbamazepine (Tegretol) 11
Lithium Carbonate (Lithium Carbonate ER) 11
Levetiracetam (Keppra) 10
Oxcarbazepine (Trileptal) 9

Show all 37 treatments patients report switching to

Last updated:

65 patient evaluations for Divalproex sodium

Jan 8, 2009 (Started Dec 31, 2008)

  • Effectiveness
    Moderate (for bipolar rapid cycling)
  • Side effects
    Mild (thirst, nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 500 mg Daily
Advice & Tips: I have only been taking this medicine just over a week and it seems to be working so far. I have experienced some very unpredictable nausea/vomitting. Its not every time I take it and it comes completely out of nowhere. Its weird. One minute I'm fine, then all of a sudden I'm running to the bathroom to get sick, then I'm completely fine again. I haven't really had any upset stomach, which makes this even more bizarre. I'm hoping this will go away with time.
Cost: < $25 monthly
Side effects: thirst, nausea, nausea

Dec 31, 2008 (Started Dec 31, 2008)

  • Effectiveness
    Moderate (for bipolar rapid cycling)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 500 mg Daily
Cost: < $25 monthly
Side effects: thirst, nausea, nausea

  • 1 helpful mark

Jul 25, 2010 (Started Dec 30, 2009)

  • Effectiveness
    Moderate (for epilepsy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 500 mg Daily
Advice & Tips: I take this medication every single day like prescribed because don't like having a seizure. It's helping me from having several seizures a day to quite a few in the week.
Cost: $100-199 monthly

  • 1 helpful mark

Nov 1, 2010 (Started Jun 30, 2010)

  • Effectiveness
    Major (for bipolar manic episodes)
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 500 mg Daily
Advice & Tips: Extreme Hair loss/ breakage of hair. Very upsetting. Its a shame because other than losing my hair it worked well.
Cost: < $25 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 65 patient evaluations for Divalproex sodium