What is Divalproex sodium?

Category: Prescription Drugs

Most popular types: Depakote Depakote ER Divalproex ER Show all

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Divalproex sodium is chemically compounded from sodium valproate and valproic acid in a 1:1 ratio. It is a delayed release, enteric coated tablet used for seizures, mania associated with bipolar disorder and prevention of migraines.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Epilepsy 579 271
Bipolar disorder 382 220
Migraine headaches 108 55
Bipolar II disorder 56 37
Bipolar I disorder 48 34
Bipolar manic episodes 45 34

Show all 117 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 182
Moderate 194
Mild 187
None 177

Commonly reported side effects and conditions associated with Divalproex sodium

Side effect Patients
Weight gain 143
Hair loss 45
Fatigue 39
Drowsiness 26
Tremor in hands 21
Nausea 18

Show all 265 reported side effects

Dosages

Based on patients currently taking Divalproex sodium

Dosage Patients
500 mg daily 20
1,000 mg daily 17
250 mg daily 15
500 mg twice daily 12
250 mg twice daily 10
750 mg daily 9
1,500 mg daily 8
2,000 mg daily 7
500 mg four times daily 5
1,250 mg daily 4

See all 30 dosages

Why patients stopped taking Divalproex sodium

Multiple reasons could be selected

Reason Patients
Side effects too severe 346
Did not seem to work 248
Doctor's advice 172
Other 106
Personal research 35
Expense 31
Course of treatment ended 26
Change in health plan coverage 11
See all 639 patients who've stopped taking Divalproex sodium

Duration

Currently taking Divalproex sodium

Duration Patients
1 - 6 months 4
6 months - 1 year 20
1 - 2 years 20
2 - 5 years 24
5 - 10 years 39
10 years or more 30

Stopped taking Divalproex sodium

Duration Patients
Less than 1 month 124
1 - 6 months 143
6 months - 1 year 74
1 - 2 years 77
2 - 5 years 125
5 - 10 years 51
10 years or more 55
Adherence
Adherence Evaluations
Always 581
Usually 115
Sometimes 22
Never taken as prescribed 22
Burden
Burden Evaluations
Very hard to take 56
Somewhat hard to take 117
A little hard to take 117
Not at all hard to take 450
Cost per month
Cost per month Evaluations
$200+ 19
$100-199 19
$50-99 33
$25-49 60
< $25 290
Not specified 319

What people switch to and from

Patients started taking Divalproex sodium after stopping:

Treatment Patients
Lithium Carbonate (Lithium Carbonate ER) 40
Lamotrigine (Lamictal) 20
Topiramate (Topamax) 16
Aripiprazole (Abilify) 10
Carbamazepine (Tegretol) 6

Show all 46 treatments patients report switching from

Patients stopped taking Divalproex sodium and switched to:

Treatment Patients
Lamotrigine (Lamictal) 32
Carbamazepine (Tegretol) 11
Levetiracetam (Keppra) 10
Lithium Carbonate (Lithium Carbonate ER) 10
Oxcarbazepine (Trileptal) 9

Show all 36 treatments patients report switching to

Last updated:

65 patient evaluations for Divalproex sodium

Jan 8, 2009 (Started Dec 31, 2008)

  • Effectiveness
    Moderate (for bipolar rapid cycling)
  • Side effects
    Mild (thirst, nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 500 mg Daily
Advice & Tips: I have only been taking this medicine just over a week and it seems to be working so far. I have experienced some very unpredictable nausea/vomitting. Its not every time I take it and it comes completely out of nowhere. Its weird. One minute I'm fine, then all of a sudden I'm running to the bathroom to get sick, then I'm completely fine again. I haven't really had any upset stomach, which makes this even more bizarre. I'm hoping this will go away with time.
Cost: < $25 monthly
Side effects: thirst, nausea, nausea

Dec 31, 2008 (Started Dec 31, 2008)

  • Effectiveness
    Moderate (for bipolar rapid cycling)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 500 mg Daily
Cost: < $25 monthly
Side effects: thirst, nausea, nausea

  • 1 helpful mark

Jul 25, 2010 (Started Dec 30, 2009)

  • Effectiveness
    Moderate (for epilepsy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 500 mg Daily
Advice & Tips: I take this medication every single day like prescribed because don't like having a seizure. It's helping me from having several seizures a day to quite a few in the week.
Cost: $100-199 monthly

  • 1 helpful mark

Nov 1, 2010 (Started Jun 30, 2010)

  • Effectiveness
    Major (for bipolar manic episodes)
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 500 mg Daily
Advice & Tips: Extreme Hair loss/ breakage of hair. Very upsetting. Its a shame because other than losing my hair it worked well.
Cost: < $25 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 65 patient evaluations for Divalproex sodium