What is Divalproex sodium?

Category: Prescription Drugs

Most popular types: Depakote Depakote ER Divalproex ER Show all

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Divalproex sodium is chemically compounded from sodium valproate and valproic acid in a 1:1 ratio. It is a delayed release, enteric coated tablet used for seizures, mania associated with bipolar disorder and prevention of migraines.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Epilepsy 579 271
Bipolar disorder 378 216
Migraine headaches 107 55
Bipolar II disorder 56 37
Bipolar I disorder 48 34
Bipolar manic episodes 45 34

Show all 122 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 181
Moderate 195
Mild 187
None 176

Commonly reported side effects and conditions associated with Divalproex sodium

Side effect Patients
Weight gain 144
Hair loss 45
Fatigue 38
Drowsiness 26
Tremor in hands 21
Nausea 18

Show all 264 reported side effects

Dosages

Based on patients currently taking Divalproex sodium

Dosage Patients
500 mg daily 24
250 mg daily 22
1,000 mg daily 18
500 mg twice daily 13
250 mg twice daily 11
750 mg daily 10
1,500 mg daily 9
2,000 mg daily 8
500 mg four times daily 5
1,250 mg daily 4

See all 31 dosages

Why patients stopped taking Divalproex sodium

Multiple reasons could be selected

Reason Patients
Side effects too severe 341
Did not seem to work 249
Doctor's advice 171
Other 106
Personal research 35
Expense 31
Course of treatment ended 25
Change in health plan coverage 11
See all 633 patients who've stopped taking Divalproex sodium

Duration

Currently taking Divalproex sodium

Duration Patients
Less than 1 month 1
1 - 6 months 11
6 months - 1 year 18
1 - 2 years 16
2 - 5 years 30
5 - 10 years 46
10 years or more 34

Stopped taking Divalproex sodium

Duration Patients
Less than 1 month 121
1 - 6 months 141
6 months - 1 year 74
1 - 2 years 77
2 - 5 years 124
5 - 10 years 50
10 years or more 55
Adherence
Adherence Evaluations
Always 583
Usually 113
Sometimes 22
Never taken as prescribed 21
Burden
Burden Evaluations
Very hard to take 56
Somewhat hard to take 117
A little hard to take 116
Not at all hard to take 450
Cost per month
Cost per month Evaluations
$200+ 19
$100-199 19
$50-99 33
$25-49 60
< $25 288
Not specified 320

What people switch to and from

Patients started taking Divalproex sodium after stopping:

Treatment Patients
Lithium Carbonate (Lithium Carbonate ER) 40
Lamotrigine (Lamictal) 17
Topiramate (Topamax) 15
Aripiprazole (Abilify) 10
Carbamazepine (Tegretol) 6

Show all 46 treatments patients report switching from

Patients stopped taking Divalproex sodium and switched to:

Treatment Patients
Lamotrigine (Lamictal) 31
Carbamazepine (Tegretol) 11
Levetiracetam (Keppra) 10
Lithium Carbonate (Lithium Carbonate ER) 10
Oxcarbazepine (Trileptal) 9

Show all 36 treatments patients report switching to

Last updated:

66 patient evaluations for Divalproex sodium

Sep 19, 2017 (Started Jun 30, 2012)

  • Effectiveness
    Slight (for bipolar disorder)
  • Side effects
    Moderate (head pressure)
  • Adherence
    Sometimes
  • Burden
    Somewhat hard to take
Dosage: 500 mg Daily
Cost: < $25 monthly

Apr 9, 2016 (Started Jun 30, 2012)

  • Effectiveness
    Slight (for bipolar disorder)
  • Side effects
    Mild (head pressure)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 250 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

May 9, 2017 (Started Mar 01, 2010)

  • Effectiveness
    Moderate (for Treat my mood condition(s))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 250 mg Daily

Dec 4, 2010 (Started Mar 01, 2010)

  • Effectiveness
    Moderate (for Treat my mood condition(s))
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 250 mg All the time (24/7)

  • 0 helpful marks

Sep 23, 2016 (Started Feb 28, 2015)

  • Effectiveness
    Major (for epilepsy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 66 patient evaluations for Divalproex sodium