What is Divalproex sodium?

Category: Prescription Drugs

Most popular types: Depakote Depakote ER Divalproex ER Show all

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Divalproex sodium is chemically compounded from sodium valproate and valproic acid in a 1:1 ratio. It is a delayed release, enteric coated tablet used for seizures, mania associated with bipolar disorder and prevention of migraines.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Epilepsy 578 270
Bipolar disorder 376 216
Migraine headaches 109 55
Bipolar II disorder 57 37
Bipolar I disorder 46 32
Bipolar manic episodes 45 34

Show all 120 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
179
Moderate
194
Mild
187
None
171

Commonly reported side effects and conditions associated with Divalproex sodium

Side effect Patients
Weight gain 139
Hair loss 44
Fatigue 38
Drowsiness 26
Tremor in hands 22
Nausea 18

Show all 269 reported side effects

Dosages

Based on patients currently taking Divalproex sodium

Dosage Patients
500 mg daily 25
1,000 mg daily 21
250 mg daily 19
500 mg twice daily 19
250 mg twice daily 11
750 mg daily 9
1,500 mg daily 9
2,000 mg daily 9
500 mg three times daily 6
500 mg four times daily 5

See all 28 dosages

Why patients stopped taking Divalproex sodium

Multiple reasons could be selected

Reason Patients
Side effects too severe 335
Did not seem to work 241
Doctor's advice 168
Other 105
Personal research 35
Expense 30
Course of treatment ended 24
Change in health plan coverage 10
See all 619 patients who've stopped taking Divalproex sodium

Duration

Currently taking Divalproex sodium

Duration Patients
1 - 6 months 10
6 months - 1 year 14
1 - 2 years 24
2 - 5 years 30
5 - 10 years 45
10 years or more 39

Stopped taking Divalproex sodium

Duration Patients
Less than 1 month 117
1 - 6 months 140
6 months - 1 year 71
1 - 2 years 77
2 - 5 years 121
5 - 10 years 49
10 years or more 53
Adherence
Adherence Evaluations
Always 579
Usually 110
Sometimes 22
Never taken as prescribed 20
Burden
Burden Evaluations
Very hard to take 56
Somewhat hard to take 114
A little hard to take 115
Not at all hard to take 446
Cost per month
Cost per month Evaluations
$200+ 19
$100-199 19
$50-99 34
$25-49 60
< $25 285
Not specified 314

What people switch to and from

Patients started taking Divalproex sodium after stopping:

Treatment Patients
Lithium Carbonate (Lithium Carbonate ER) 38
Lamotrigine (Lamictal) 16
Topiramate (Topamax) 15
Aripiprazole (Abilify) 10
Sertraline (Zoloft) 7

Show all 46 treatments patients report switching from

Patients stopped taking Divalproex sodium and switched to:

Treatment Patients
Lamotrigine (Lamictal) 29
Carbamazepine (Tegretol) 10
Levetiracetam (Keppra) 10
Lithium Carbonate (Lithium Carbonate ER) 10
Oxcarbazepine (Trileptal) 10

Show all 36 treatments patients report switching to

Last updated:

67 patient evaluations for Divalproex sodium

Sep 19, 2017 (Started Jun 30, 2012)

  • Effectiveness
    Slight (for bipolar disorder)
  • Side effects
    Moderate (head pressure)
  • Adherence
    Sometimes
  • Burden
    Somewhat hard to take
Dosage: 500 mg Daily
Cost: < $25 monthly

Apr 9, 2016 (Started Jun 30, 2012)

  • Effectiveness
    Slight (for bipolar disorder)
  • Side effects
    Mild (head pressure)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 250 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

May 10, 2017 (Started Mar 09, 2017)

  • Effectiveness
    Moderate (for bipolar disorder)
  • Side effects
    Severe (very low white blood cell count)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 500 mg Daily
Advice & Tips: had to sto[ WBC dropped to 3
Cost: < $25 monthly

  • 0 helpful marks

May 9, 2017 (Started Mar 01, 2010)

  • Effectiveness
    Moderate (for Treat my mood condition(s))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 250 mg All the time (24/7)

Dec 4, 2010 (Started Mar 01, 2010)

  • Effectiveness
    Moderate (for Treat my mood condition(s))
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 250 mg All the time (24/7)

  • 0 helpful marks
Last updated:
Showing 3 of 67 patient evaluations for Divalproex sodium